{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:06:55Z","timestamp":1792098415053,"version":"4.4.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:p>Ropivacaine is a long-acting amide local anaesthetic agent and first produced as a pure enantiomer. It produces effects similar to other local anaesthetics via reversible inhibition of sodium ion influx in nerve fibres. Ropivacaine is less lipophilic than bupivacaine and is less likely to penetrate large myelinated motor fibres, resulting in a relatively reduced motor blockade. Thus, ropivacaine has a greater degree of motor sensory differentiation, which could be useful when motor blockade is undesirable. The reduced lipophilicity is also associated with decreased potential for central nervous system toxicity and cardiotoxicity. The drug displays linear and dose proportional pharmacokinetics (up to 80 mg administered intravenously). It is metabolised extensively in the liver and excreted in urine. The present article details the clinical applications of ropivacaine and its current place as a local anaesthetic in the group.<\/jats:p>","DOI":"10.4103\/0019-5049.79875","type":"journal-article","created":{"date-parts":[[2011,5,7]],"date-time":"2011-05-07T10:43:39Z","timestamp":1304765019000},"page":"104-110","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":304,"title":["Ropivacaine: A review of its pharmacology and clinical use"],"prefix":"10.4103","volume":"55","author":[{"given":"Gaurav","family":"Kuthiala","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Critical Care, SPS Apollo Hospitals, Ludhiana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geeta","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, SPS Apollo Hospitals, Ludhiana, 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