{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:36:52Z","timestamp":1786649812393,"version":"build-2736575974"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The present study was undertaken to detect and compare the pattern of collagen fibers in odontogenic cysts and also to find out if this methodology could be used to predict the aggressive nature of odontogenic cysts by comparing with the odontogenic tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The collagen in the wall of 11 odontogenic keratocysts, 14 dentigerous cysts and 14 radicular cysts was studied histochemically by staining sections with picrosirius red and examining under polarizing microscope. This was compared to 10 cases of odontogenic tumors using Z test of proportion at 1% and 5%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In dentigerous cysts, odontogenic keratocysts and odontogenic tumors, the predominant color of collagen fibers birefringence was found to be orangish red, whereas in radicular cysts the collagen fiber was of green color.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Similar birefringence pattern of collagen fibers between dentigerous cysts, odontogenic keratocysts and odontogenic tumors may indicate that these lesions have a common histogenesis with a broad spectrum of biological behavior and belong to the same group, i.e., are developmental in origin. Different patterns of radicular cysts suggest different biological behavior and a positive role of inflammation on polarization color of collagen fibers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0019-509x.82897","type":"journal-article","created":{"date-parts":[[2011,7,15]],"date-time":"2011-07-15T02:13:36Z","timestamp":1310696016000},"page":"211-215","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["Stromal differences in odontogenic cysts of a common histopathogenesis but with different biological behavior: A study with picrosirius red and polarizing microscopy"],"prefix":"10.4103","volume":"48","author":[{"given":"P","family":"Aggarwal","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Subharti Dental College, Meerut, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Subharti Dental College, Meerut, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2011,7,11]]},"reference":[{"key":"R1-20260604","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1600-0714.1975.tb01738.x","article-title":"The pathogenesis of odontogenic cysts: A review","volume":"4","author":"Browne","year":"1975","journal-title":"J Oral Pathol"},{"key":"R2-20260604","first-page":"97","article-title":"Collagen and picrosirius red staining: A polarized light assessment of fibrillar hue and spatial distribution","volume":"22","author":"Whittaker","year":"2005","journal-title":"Braz J Morphol Sci"},{"key":"R3-20260604","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/BF01002772","article-title":"Picrosirius staining plus polarizing microscopy: A specific method for collagen detection in tissue sections","volume":"11","author":"Junqueria","year":"1979","journal-title":"Histochem J"},{"key":"R4-20260604","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1097\/00000372-199108000-00008","article-title":"Wolman M. Connective tissue nevi collagens: Study with picrosirius red and polarizing microscope","volume":"13","author":"Trau","year":"1991","journal-title":"Am J Drematopathol"},{"key":"R5-20260604","first-page":"225","article-title":"Polarization microscopy of picrosirius red-stained collagen from oxidipine-induced hyperplastic gingival of beagle dogs","volume":"74","author":"Dayan","year":"1993","journal-title":"Int J Exp Pathol"},{"key":"R6-20260604","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1600-0714.1995.tb01173.x","article-title":"Ameloblastic fibroma in a young cat","volume":"24","author":"Nysha","year":"1995","journal-title":"J Oral Pathol Med"},{"key":"R7-20260604","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1600-0714.1996.tb00206.x","article-title":"The central odontogenic fibroma and the hyperplastic dental follicle: Study with picrosiruis red and polarizing microscopy","volume":"25","author":"Hirshberg","year":"1996","journal-title":"J Oral Pathol Med"},{"key":"R8-20260604","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.oraloncology.2006.03.019","article-title":"The influence of inflammation on polarization color of collagen fibers in the wall of odontogenic Keratocyst","volume":"43","author":"Hirshberg","year":"2007","journal-title":"Oral Oncol"},{"key":"R9-20260604","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.acthis.2006.05.007","article-title":"Stromal differences in salivary gland tumors of a common histopathogenesis but with different biological behavior: A study with picrosirius red and polarizing microscopy","volume":"108","author":"Allon","year":"2006","journal-title":"Acta Histochem"},{"key":"R10-20260604","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1600-0714.1992.tb00093.x","article-title":"Ectomesenchyme of ameloblastic fibroma reveals a characteristic distribution of extracellular matrix proteins","volume":"21","author":"Becker","year":"1992","journal-title":"J Oral Pathol med"},{"key":"R11-20260604","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0049-0172(74)90001-8","article-title":"Collagen: Its structure and function in normal and pathological connective tissues","volume":"4","author":"Nimmi","year":"1974","journal-title":"Semin Arthritis Rheumat"},{"key":"R12-20260604","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/BF00491775","article-title":"dermal collagen distribution: A histochemical and ultrastructural study","volume":"79","author":"Junqueira","year":"1983","journal-title":"Histochemistry"},{"key":"R13-20260604","doi-asserted-by":"crossref","first-page":"5464","DOI":"10.1016\/S0021-9258(17)33082-X","article-title":"Biochemical characterization of collagens synthesized by fibroblasts derived from normal and diseased human gingiva","volume":"25","author":"Narayanan","year":"1976","journal-title":"J Biol Chem"},{"key":"R14-20260604","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF00495061","article-title":"The influence of tissue section thickness on the study of collagen by the picrosirius-polarization method","volume":"74","author":"Junqueria","year":"1982","journal-title":"Histochemistry"},{"key":"R15-20260604","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1600-0722.1995.tb00015.x","article-title":"Characterization of interstitial collagenases in jaw cyst wall","volume":"103","author":"Teronen","year":"1995","journal-title":"Eur J Oral Sci"},{"key":"R16-20260604","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1600-0714.1995.tb01143.x","article-title":"Identification and characterization of gelatinases \/type IV collagenases in jaw cysts","volume":"24","author":"Teonen","year":"1995","journal-title":"J Oral Pathol Med"},{"key":"R17-20260604","first-page":"1","article-title":"Interleukin 1- like activity in cystic lesions of the jaw","volume":"27","author":"Megha","year":"1989","journal-title":"Br J Oral Maxillofacial Surg"},{"key":"R18-20260604","first-page":"306","article-title":"Human odontogenic keratocyst transplant in nude mice","volume":"90","author":"Vedtofte","year":"1982","journal-title":"Scand J Dent Res"},{"key":"R19-20260604","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1600-0714.1999.tb02112.x","article-title":"Collagen fibres in the wall of odontogenic keratocysts: A study with picrosirius red and polarizing microscopy","volume":"28","author":"Hirshberg","year":"1999","journal-title":"J Oral Pathol Med"},{"key":"R20-20260604","first-page":"23","article-title":"Admantinoblastoma in the style stock of mice","volume":"20","author":"Zegarelli","year":"1994","journal-title":"Am J Pathol"},{"key":"R21-20260604","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/0030-4220(67)90080-1","article-title":"Odontogenic tumors: A Unitarian concept","volume":"24","author":"Spongue","year":"1967","journal-title":"Oral Surg"}],"container-title":["Indian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/02223310-201148020-00013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:58:41Z","timestamp":1786647521000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02223310-201148020-00013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.4103\/0019-509x.82897","relation":{},"ISSN":["0019-509X","1998-4774"],"issn-type":[{"value":"0019-509X","type":"print"},{"value":"1998-4774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}