{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:25:31Z","timestamp":1787757931591,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,4]]},"abstract":"\n Objective:<\/jats:title>\n Due to the low sensitivity of Pap smear, premalignant lesions of the cervix can be missed in women with inflammatory Pap smears. However, it is not practically possible to subject all women with inflammatory Pap smear to colposcopy. This study was carried out with the aim to evaluate whether women with persistent inflammation on Pap smear need further evaluation with colposcopy.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n Four hundred and twenty women were screened at a tertiary level hospital with Pap smear. Women with inflammation on Pap smear were given treatment as per WHO guidelines and Pap smear was repeated at an interval of 6-12 weeks. Women with persistent inflammation on Pap smear were then subjected to colposcopy and directed biopsy if required.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Of the 420 women screened, 102 (24.3%) women had a Pap smear showing inflammation. Thirty six women (8.6%) had persistent inflammatory Pap smear. Thirty women were subjected to colposcopy and 16 (53.3%) had abnormal findings on colposcopy. Five out of these 30 women (16.67%) had Cervical intraepithelial neoplasia (CIN) on biopsy.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Nearly 16.67% women with persistent inflammation on Pap smear had cervical intraepithelial neoplasia. Hence, a large number of women with CIN would be missed if persistent inflammation on Pap smear is not evaluated further.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/0019-509x.82901","type":"journal-article","created":{"date-parts":[[2011,7,15]],"date-time":"2011-07-15T02:13:36Z","timestamp":1310696016000},"page":"220-222","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Persistent inflammation on Pap smear: Does it warrant evaluation?"],"prefix":"10.4103","volume":"48","author":[{"given":"K","family":"Bhutia","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Lady Hardinge Medical College, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Puri","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Lady Hardinge Medical College, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Gami","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Lady Hardinge Medical College, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Lady Hardinge Medical College, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SS","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Lady Hardinge Medical College, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2011,7,11]]},"reference":[{"key":"R1-20260604","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1002\/1097-0142(19931115)72:10<3002::AID-CNCR2820721023>3.0.CO;2-4","article-title":"Cervical cytopathology: An evaluation of its accuracy based on cytohistologic comparison","volume":"72","author":"DiBonito","year":"1993","journal-title":"Cancer"},{"key":"R2-20260604","first-page":"817","article-title":"Paponicolou smear and screening for cervical neoplasia","volume":"35","author":"Wilkinson","year":"1990","journal-title":"Obstet Gynecol"},{"key":"R3-20260604","first-page":"1043","article-title":"False negative result in cervical cytological studies","volume":"29","author":"Gay","year":"1985","journal-title":"Acta Cytol"},{"key":"R4-20260604","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0020-7292(97)00113-6","article-title":"Routine colposcopic evaluation of patients with persistent inflammatory cellular changes on Pap smear","volume":"59","author":"Se\u00e7kin","year":"1997","journal-title":"Int J Gynaecol Obstet"},{"key":"R5-20260604","first-page":"531","article-title":"Management of suboptimal cytological smears","volume":"38","author":"McLachlan","year":"1994","journal-title":"Acta Cytol"},{"key":"R6-20260604","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1699-0463.1995.tb01106.x","article-title":"Significance of inflammatory cervical smears","volume":"103","author":"Parashari","year":"1995","journal-title":"APMIS"},{"key":"R7-20260604","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/0029-7844(95)00196-X","article-title":"The inflammatory Papnicolaou smear: What does it mean?","volume":"86","author":"Eckert","year":"1995","journal-title":"Obstet Gynecol"},{"key":"R9-20260604","first-page":"175","article-title":"International terminology of colposcopy: An updated report from the International Federation for Cervical Pathology and Colposcopy","volume":"101","author":"Walker","year":"2003","journal-title":"Obstet Gynecol"},{"key":"R10-20260604","first-page":"62","article-title":"Cervical cytology in prostitutes of Bombay (India)","volume":"68","author":"Mali","year":"1992","journal-title":"Genitourin Med"},{"key":"R11-20260604","first-page":"56","article-title":"Experience with 40,000 Papanicolaou smears","volume":"48","author":"Sandmire","year":"1976","journal-title":"Obstet Gynecol"},{"key":"R12-20260604","first-page":"237","article-title":"Management of initial atypical cervical cytology: A randomized, prospective study","volume":"68","author":"Reiter","year":"1986","journal-title":"Obstet Gynecol"},{"key":"R13-20260604","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/0029-7844(94)00373-L","article-title":"Comparison of management algorithms for the evaluation of women with low-grade cytologic abnormalities","volume":"85","author":"Wright","year":"1995","journal-title":"Obstet Gynecol"},{"key":"R14-20260604","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/0029-7844(95)00041-O","article-title":"Low-grade Papanicolaou smears and the Bethesda system: A prospective cytohistopathologic analysis","volume":"85","author":"Lonky","year":"1995","journal-title":"Obstet Gynecol"},{"key":"R15-20260604","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ajog.2007.07.047","article-title":"2006 consensus guidelines for the management of women with abnormal cervical cancer screening tests","volume":"197","author":"Wright","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"R16-20260604","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4103\/1742-6413.67112","article-title":"Colposcopic evaluation of persistent inflammatory Pap smear: A prospective analytical study","volume":"7","author":"Dasari","year":"2010","journal-title":"Cytojournal"}],"container-title":["Indian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/02223310-201148020-00015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:59:59Z","timestamp":1787756399000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02223310-201148020-00015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.4103\/0019-509x.82901","relation":{},"ISSN":["0019-509X","1998-4774"],"issn-type":[{"value":"0019-509X","type":"print"},{"value":"1998-4774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}