{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:40:07Z","timestamp":1787071207995,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Lichen planus (LP) is a common disorder whose etiopathogenesis is not clear. Recently, it has been suggested that increased reactive oxygen species (ROS) play important roles in the underlying mechanism of LP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The principal aim of this study was to evaluate serum uric acid (UA) levels as a measure of the antioxidant defense status in LP patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Serum UA levels were determined in 58 LP patients and 61 controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Serum UA levels were significantly decreased in patients with respect to controls. Moreover, serum UA level was decreased according to increasing duration of disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The results of our study suggest that LP is associated with decrease of UA levels in serum. UA may be a potential, useful biomarker of antioxidant status in LP for elaboration of treatment strategy and monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0019-5154.143510","type":"journal-article","created":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T03:05:15Z","timestamp":1414551915000},"page":"558-561","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Altered Serum Uric Acid Level in Lichen Planus Patients"],"prefix":"10.4103","volume":"59","author":[{"given":"Goutam","family":"Chakraborti","sequence":"first","affiliation":[{"name":"From the Department of Biochemistry, Murshidabad Medical College and Hospital, Berhampore, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabindranath","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Murshidabad Medical College and Hospital, Berhampore, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandip","family":"Chakraborti","sequence":"additional","affiliation":[{"name":"From the Department of Biochemistry, Murshidabad Medical College and Hospital, Berhampore, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradyot Kumar","family":"Sen","sequence":"additional","affiliation":[{"name":"From the Department of Biochemistry, Murshidabad Medical College and Hospital, Berhampore, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250921","first-page":"59","article-title":"Lichen planus: An update","volume":"4","author":"Gupta","year":"2013","journal-title":"Int J Pharm Biomed Sci"},{"key":"R3-20250921","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1159\/000326074","article-title":"Interaction between Carotenoids and Free Radicals in Human Skin","volume":"24","author":"Lademann","year":"2011","journal-title":"Skin Pharmacol Physiol"},{"key":"R4-20250921","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.1365-2133.2004.06142.x","article-title":"Oxidative stress is implicated in the pathogenesis of lichen sclerosis","volume":"151","author":"Sander","year":"2004","journal-title":"Br J Dermatol"},{"key":"R5-20250921","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1365-2230.2007.02436.x","article-title":"Lipid peroxidation and antioxidant status in lichen planus","volume":"32","author":"Sezer","year":"2007","journal-title":"Clin Exp Dermatol"},{"key":"R6-20250921","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0891-5849(00)00482-2","article-title":"Redox modulated pathways in inflammatory skin diseases","volume":"30","author":"Fuchs","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"R7-20250921","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1089\/ars.2005.7.482","article-title":"Redox regulation of apoptosis by members of the TNF Superfamily","volume":"7","author":"Shakibaei","year":"2005","journal-title":"Antioxid Redox Signal"},{"key":"R8-20250921","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/cdd.2010.5","article-title":"Granzymes in age-related cardiovascular and pulmonary diseases","volume":"17","author":"Hendel","year":"2010","journal-title":"Cell Death Differ"},{"key":"R9-20250921","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1007\/s11064-012-0755-8","article-title":"Elevated oxidative stress and decreased antioxidant function in the human hippocampus and frontal cortex with increasing age: Implications for Neurodegeneration in Alzheimer's Disease","volume":"37","author":"Venkateshappa","year":"2012","journal-title":"Neurochem Res"},{"key":"R10-20250921","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1080\/10408398.2011.649149","article-title":"Authors\u2019 Perspective: What is the optimum intake of vitamin C in humans?","volume":"52","author":"Frei","year":"2012","journal-title":"Crit Rev Food Sci Nutr"},{"key":"R11-20250921","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1039\/c2md20287e","article-title":"Synthesis, radical scavenging activity and structure\u2013activity relationship of uric acid analogs","volume":"4","author":"Yasuda","year":"2013","journal-title":"Med Chem Commun"},{"key":"R13-20250921","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1159\/000246152","article-title":"Lichen planus associated with metformin therapy","volume":"194","author":"Azzam","year":"1997","journal-title":"Dermatology"},{"key":"R14-20250921","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/biof.5520330406","article-title":"Oxidative stress markers in oral lichen planus","volume":"33","author":"Battino","year":"2008","journal-title":"Biofactors"},{"key":"R15-20250921","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1093\/clinchem\/24.11.1908","article-title":"New enzymatic method for serum uric acid at 500 nm","volume":"24","author":"Trivedi","year":"1978","journal-title":"Clin Chem"},{"key":"R16-20250921","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.2174\/138161205774913255","article-title":"Uric acid and oxidative stress","volume":"11","author":"Glantzounis","year":"2005","journal-title":"Curr Pharm Des"},{"key":"R17-20250921","doi-asserted-by":"crossref","first-page":"63","DOI":"10.11613\/BM.2012.007","article-title":"Uric acid as one of the important factors in multifactorial disorders-facts and controversies","volume":"22","author":"Pasalic","year":"2012","journal-title":"Biochem Med (Zagreb)"},{"key":"R18-20250921","first-page":"539","article-title":"Uric acid and cardiovascular risk","volume":"360","author":"Parmar","year":"2009","journal-title":"N Engl J Med"},{"key":"R19-20250921","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric oxide and peroxynitrite in health and disease","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiol Rev"},{"key":"R20-20250921","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.107.129031","article-title":"Altered uric acid levels and disease states","volume":"324","author":"Kutzing","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"R21-20250921","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.2337\/db06-0283","article-title":"Uric acid restores endothelial function in patients with type 1 diabetes and regular smokers","volume":"55","author":"Waring","year":"2006","journal-title":"Diabetes"},{"key":"R22-20250921","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1096\/fasebj.14.5.691","article-title":"Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis","volume":"14","author":"Hooper","year":"2000","journal-title":"FASEB"},{"key":"R23-20250921","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1365-4362.1992.tb02663.x","article-title":"Lichen planus and lichen planus-like eruptions: Pathogenesis and associated diseases","volume":"31","author":"Shai","year":"1992","journal-title":"Int J Dermatol"},{"key":"R24-20250921","first-page":"139","article-title":"The antioxidant potential of saliva: Clinical significance in oral diseases","volume":"15","author":"Miricescu","year":"2011","journal-title":"Ther Pharmacol Clin Toxicol"},{"key":"R25-20250921","first-page":"91","article-title":"Salivary vitamin E and C in lichen planus","volume":"6","author":"Rai","year":"2008","journal-title":"Gomal J Med Sci"},{"key":"R26-20250921","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/00005344-200109000-00005","article-title":"Systemic uric acid administration increases serum antioxidant capacity in healthy volunteers","volume":"38","author":"Waring","year":"2001","journal-title":"J Cardiovasc Pharmacol"},{"key":"R27-20250921","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4103\/0972-124X.107469","article-title":"Antioxidant therapy as monotherapy or as an adjunct to treatment of periodontal diseases","volume":"17","author":"Mathur","year":"2013","journal-title":"J Indian Soc Periodontol"}],"container-title":["Indian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00076423-201459060-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:43:06Z","timestamp":1787067786000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00076423-201459060-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.4103\/0019-5154.143510","relation":{},"ISSN":["0019-5154","1998-3611"],"issn-type":[{"value":"0019-5154","type":"print"},{"value":"1998-3611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"2013-03-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-01","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}