{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:40:14Z","timestamp":1787071214079,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,11]]},"abstract":"\n Background:<\/jats:title>\n Chronic plaque psoriasis is a common papulosquamous skin disorder, for which a number of topical agents are being used including coal tar, topical steroids and more recently topical calcipotriol\/betamethasone dipropionate. There is no study comparing purified coal tar preparation with calcipotriol\/betamethasone dipropionate ointment in limited chronic plaque psoriasis.<\/jats:p>\n <\/jats:sec>\n \n Aims and Objectives:<\/jats:title>\n A prospective randomized open label controlled trial to compare the efficacy and safety of topical application of coal tar-salicylic acid ointment with calcipotriol\/betamethasone dipropionate ointment applied once at night for 12 weeks for the treatment of limited chronic plaque psoriasis.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n A total of 62 patients of limited chronic plaque psoriasis (body surface area <10%) were randomized into two treatment groups: Group A received topical application of 6% coal tar with 3% salicylic acid ointment and Group B received calcipotriol\/betamethasone dipropionate, once at night for 12 weeks. Results were assessed based on psoriasis area severity index (PASI) scores and patient global assessment (PGA) at each visit.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Mean PASI was significantly lower at week 2 (\n P<\/jats:italic>\n = 0.01) and week 4 follow-up (\n P<\/jats:italic>\n = 0.05) and the mean reduction in PASI was significantly higher at week 2 (\n P<\/jats:italic>\n = 0.02) with calcipotriol\/betamethasone than coal tar-salicylic acid, but this difference was not sustained at subsequent follow-up visits. Similarly, PGA scores at weeks 2 and 4 were significantly lower with calcipotriol\/betamethasone dipropionate ointment (\n P<\/jats:italic>\n = 0.003 and\n P<\/jats:italic>\n = 0.007 respectively). There was no significant difference in any parameter during subsequent follow-up visits or at the end of the treatment phase (12 weeks).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Topical nightly application of calcipotriol\/betamethasone dipropionate ointment leads to an initial, more rapid reduction in disease severity, but the overall outcome parameters are comparable in the two treatment groups.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/0019-5154.143523","type":"journal-article","created":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T03:05:15Z","timestamp":1414551915000},"page":"579-583","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["An Open Label Prospective Randomized Trial to Compare the Efficacy of Coal Tar-Salicylic Acid Ointment Versus Calcipotriol\/Betamethasone Dipropionate Ointment in the Treatment of Limited Chronic Plaque Psoriasis"],"prefix":"10.4103","volume":"59","author":[{"given":"Sujay","family":"Khandpur","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanika","family":"Sahni","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250921","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1365-2230.2009.03610.x","article-title":"Topical tazarotene vs. coal tar in stable plaque psoriasis","volume":"35","author":"Kumar","year":"2010","journal-title":"Clin Exp Dermatol"},{"key":"R2-20250921","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1046\/j.1365-2133.2002.04967.x","article-title":"Efficacy and safety of a new combination of calcipotriol and betamethasone dipropionate (once or twice daily) compared to calcipotriol (twice daily) in the treatment of psoriasis vulgaris: A randomized, double-blind, vehicle-controlled clinical trial","volume":"147","author":"Guenther","year":"2002","journal-title":"Br J Dermatol"},{"key":"R3-20250921","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000323408","article-title":"Calcipotriol plus betamethasone dipropionate gel compared with tacalcitol ointment and the gel vehicle alone in patients with psoriasis vulgaris: A randomized, controlled clinical trial","volume":"222","author":"Langley","year":"2011","journal-title":"Dermatology"},{"key":"R4-20250921","first-page":"5","article-title":"Optimizing topical therapies for treating psoriasis: A consensus conference","volume":"86","author":"Zeichner","year":"2010","journal-title":"Cutis"},{"key":"R5-20250921","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2310\/7750.2011.10080","article-title":"Topical psoriasis therapy in the age of biologics: Evidence-based treatment recommendations","volume":"15","author":"Albrecht","year":"2011","journal-title":"J Cutan Med Surg"},{"key":"R6-20250921","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1046\/j.1365-4362.1999.00500.x","article-title":"The role of salicylic acid in the treatment of psoriasis","volume":"38","author":"Lebwohl","year":"1999","journal-title":"Int J Dermatol"},{"key":"R7-20250921","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jaad.2008.11.024","article-title":"Topical tar: Back to the future","volume":"61","author":"Paghdal","year":"2009","journal-title":"J Am Acad Dermatol"},{"key":"R8-20250921","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1517\/14656566.4.12.2347","article-title":"The efficacy of topical tazarotene monotherapy and combination therapies in psoriasis","volume":"4","author":"Koo","year":"2003","journal-title":"Expert Opin Pharmacother"},{"key":"R9-20250921","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/09546630600999219","article-title":"Calcipotriol cream: A review of its use in the management of psoriasis","volume":"17","author":"Segaert","year":"2006","journal-title":"J Dermatolog Treat"},{"key":"R10-20250921","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2165\/00128071-200102020-00008","article-title":"Calcipotriol ointment. A review of its use in the management of psoriasis","volume":"2","author":"Scott","year":"2001","journal-title":"Am J Clin Dermatol"},{"key":"R11-20250921","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2165\/11207670-000000000-00000","article-title":"Spotlight on calcipotriene\/betamethasone dipropionate in psoriasis vulgaris of the trunk, limbs, and scalp","volume":"12","author":"McCormack","year":"2011","journal-title":"Am J Clin Dermatol"},{"key":"R12-20250921","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1046\/j.1365-4362.2003.01974.x","article-title":"Calcipotriol versus coal tar: A prospective randomized study in stable plaque psoriasis","volume":"42","author":"Sharma","year":"2003","journal-title":"Int J Dermatol"},{"key":"R13-20250921","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1742-1241.1997.tb09619.x","article-title":"Comparative effects of calcipotriol ointment (50 micrograms\/g) and 5% coal tar\/2% allantoin\/0.5% hydrocortisone cream in treating plaque psoriasis","volume":"51","author":"Pinheiro","year":"1997","journal-title":"Br J Clin Pract"},{"key":"R14-20250921","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1365-2133.1994.tb04981.x","article-title":"A comparative study of calcipotriol ointment and tar in chronic plaque psoriasis","volume":"131","author":"Tham","year":"1994","journal-title":"Br J Dermatol"},{"key":"R15-20250921","first-page":"275","article-title":"Efficacy and tolerability of a cosmetically acceptable coal tar solution in the treatment of moderate plaque psoriasis: A controlled comparison with calcipotriene (calcipotriol) cream","volume":"11","author":"Alora-Palli","year":"2010","journal-title":"Am J Clin Dermatol"}],"container-title":["Indian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00076423-201459060-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:43:10Z","timestamp":1787067790000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00076423-201459060-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.4103\/0019-5154.143523","relation":{},"ISSN":["0019-5154","1998-3611"],"issn-type":[{"value":"0019-5154","type":"print"},{"value":"1998-3611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"2013-06-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-08-01","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}