{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:39:58Z","timestamp":1787071198732,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The pathergy test (PT) is important in the diagnosis of Beh\u00e7et's disease (BD). However, misinterpretation of the test might cause false-positive or false-negative results. Therefore, immunopathologic and histopathologic tests are recommended with PT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims and Objectives:<\/jats:title>\n                    <jats:p>The aim of this study is to determine histopathologic findings of positive pathergy reaction at BD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This study was performed on 23 patients with BD. All patients were in active period of the disease. After 48 h from the injection, biopsy was performed on positive pathergy lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the specimen from positive PT lesions of patients with BD, nine revealed mixed type inflammatory cell infiltration (39.1%), two revealed lobular panniculitis without vasculitis (8.7%), two revealed neutrophil rich infiltration (8.7%), and five revealed lymphocyte rich infiltration (21.7%) at the subcutaneous tissue. Mixed type inflammatory cell infiltration (43.4%), endothelial swelling and thickening (17.3%), erythrocyte extravasation (26.0%), perivascular cell infiltration (13.0%), lymphocytic vascular reaction (8.6%), lymphocytic vasculitis (13.0%), and leukocytoclastic vasculitis (21.7%) were detected in dermis by histopathologic examinations. There was no statistically significant difference between histopathologic findings and sex, family history, and systemic involvement except uveitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This is an exceptional study since it is the first study that determines subcutaneous tissue findings of positive pathergy reaction in Beh\u00e7et patients. In our study, uveitis was found to be statistically significant in the patients who had vasculitis in dermis. It can be a clue for prediction of disease severity and course. Further, studies that include wide number of patients will better illuminate the correlation between subcutaneous tissue findings and disease severity and clinical course.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0019-5154.143568","type":"journal-article","created":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T03:05:15Z","timestamp":1414551915000},"page":"630-630","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Histopathologic Study of Pathergy Test in Beh\u00e7et's Disease"],"prefix":"10.4103","volume":"59","author":[{"given":"Ekin","family":"Ozluk","sequence":"first","affiliation":[{"name":"From the Department of Dermatology, Ministry of Health, Kocaeli State Hospital, Kocaeli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilknur","family":"Balta","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kecioren Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Akoguz","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ankara Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goknur","family":"Kalkan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Gaziosmanpasa University, School of Medicine, Tokat, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzeyyen","family":"Astarci","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ankara Training and Research Hospital, Ankara, Turkey"},{"name":"Department of Pathology, Ministry of Health, Kocaeli State Hospital, Kocaeli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulfer","family":"Akbay","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ankara Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meral","family":"Eksioglu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ankara Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250921","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0190-9622(99)70523-2","article-title":"Beh\u00e7et's disease and complex aphthosis","volume":"40","author":"Ghate","year":"1999","journal-title":"J Am Acad Dermatol"},{"key":"R2-20250921","first-page":"1078","article-title":"Criteria for diagnosis of Behcet's disease. International Study Group for Behcet's disease","volume":"335","year":"1990","journal-title":"Lancet"},{"key":"R3-20250921","first-page":"17","article-title":"Sutton's aphthae and Beh\u00e7et's syndrome","volume":"30","author":"Mittal","year":"1985","journal-title":"Indian J Dermatol"},{"key":"R4-20250921","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4103\/0019-5154.94273","article-title":"Serum lipid, lipoprotein and oxidatively modified low density lipoprotein levels in active or inactive patients with Beh\u00e7et's disease","volume":"57","author":"Cimen","year":"2012","journal-title":"Indian J Dermatol"},{"key":"R5-20250921","first-page":"47","article-title":"Comparison of clinical and histopathologic findings of pathergy test with disposable\/sharp and nondisposable\/blunt needles in Beh\u00e7et's Disease","volume":"39","author":"Karadag","year":"2009","journal-title":"Turk J Med Sci"},{"key":"R6-20250921","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1046\/j.1365-4362.2000.00884.x","article-title":"Comparison of histopathologic and clinical evaluations of pathergy test in Beh\u00e7et's disease","volume":"39","author":"Akmaz","year":"2000","journal-title":"Int J Dermatol"},{"key":"R7-20250921","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1136\/ard.52.11.823","article-title":"Comparative study of the skin pathergy test with blunt and sharp needles in Behcet's disease: Confirmed specificity but decreased sensitivity with sharp needles","volume":"52","author":"Dil\u015fen","year":"1993","journal-title":"Ann Rheum Dis"},{"key":"R8-20250921","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00403-009-1008-9","article-title":"The skin pathergy test: Innately useful?","volume":"302","author":"Varol","year":"2010","journal-title":"Arch Dermatol Res"},{"key":"R9-20250921","first-page":"129","article-title":"Zur rezidivierenden. Hypopyon-Iritis","volume":"91","author":"Blobner","year":"1937","journal-title":"Z Augenheilk"},{"key":"R10-20250921","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1046\/j.1365-4362.1998.00474.x","article-title":"The histopathology of pathergy: A chronologic study of skin hyperreactivity in Beh\u00e7et's disease","volume":"37","author":"Ergun","year":"1998","journal-title":"Int J Dermatol"},{"key":"R11-20250921","first-page":"747","article-title":"Beh\u00e7et's syndrome. Immunopathologic and histopathologic assessment of pathergy lesions is useful in diagnosis and follow-up","volume":"109","author":"Jorizzo","year":"1985","journal-title":"Arch Pathol Lab Med"},{"key":"R12-20250921","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/j.1365-2133.1976.tb07036.x","article-title":"Histological and direct immunofluorescence study of cutaneous hyperreactivity in Beh\u00e7et's disease","volume":"95","author":"Haim","year":"1976","journal-title":"Br J Dermatol"},{"key":"R13-20250921","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000250740","article-title":"The pathogenesis of lesions in Beh\u00e7et's disease","volume":"158","author":"Haim","year":"1979","journal-title":"Dermatologica"},{"key":"R14-20250921","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/0190-9622(95)91333-5","article-title":"Mucocutaneous criteria for the diagnosis of Beh\u00e7et's disease: An analysis of clinicopathologic data from multiple international centers","volume":"32","author":"Jorizzo","year":"1995","journal-title":"J Am Acad Dermatol"},{"key":"R15-20250921","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0190-9622(88)70264-9","article-title":"Neutrophilic vascular reactions","volume":"19","author":"Jorizzo","year":"1988","journal-title":"J Am Acad Dermatol"},{"key":"R16-20250921","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1346-8138.1990.tb01653.x","article-title":"Histopathologic study of cutaneous lesions in Beh\u00e7et's syndrome","volume":"17","author":"Chun","year":"1990","journal-title":"J Dermatol"},{"key":"R17-20250921","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1046\/j.1365-4362.1998.00276.x","article-title":"Histopathologic features of the spontaneous pustular lesions of Beh\u00e7et's syndrome","volume":"37","author":"Ergun","year":"1998","journal-title":"Int J Dermatol"},{"key":"R18-20250921","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/00000372-200010000-00001","article-title":"Histopathologic features of erythema nodosum-like lesions in Beh\u00e7et's disease: A comparison with erythema nodosum focusing on the role of vasculitis","volume":"22","author":"Kim","year":"2000","journal-title":"Am J Dermatopathol"}],"container-title":["Indian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00076423-201459060-00035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:42:57Z","timestamp":1787067777000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00076423-201459060-00035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.4103\/0019-5154.143568","relation":{},"ISSN":["0019-5154","1998-3611"],"issn-type":[{"value":"0019-5154","type":"print"},{"value":"1998-3611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"2013-02-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-01","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}