{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:40:23Z","timestamp":1787071223961,"version":"build-2736575974"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>Bowen's disease is generally regarded as premalignant dermatoses. The disease affects both skin and the mucosa and has the potential to progress to invasive squamous cell carcinoma. There are descriptions of several histological variants of Bowen's disease like psoriasiform, atrophic, pagetoid, etc. Acantholysis of anaplastic keratinocytes with bullae\/cleft formation is described in premalignant condition like actinic keratosis and adenoid variant of squamous cell carcinoma, but there is lack of report describing this phenomena in Bowen's disease. We present a case of unusual acantholytic variant of Bowen's disease with focus of micro-invasive carcinoma.<\/jats:p>","DOI":"10.4103\/0019-5154.143592","type":"journal-article","created":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T03:05:15Z","timestamp":1414551915000},"page":"635-635","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Acantholytic Variant of Bowen's Disease with Micro-invasive Squamous Cell Carcinoma: A Case Report of a Unique Variant"],"prefix":"10.4103","volume":"59","author":[{"given":"Kanthilatha","family":"Pai","sequence":"first","affiliation":[{"name":"From the Department of Pathology, Kasturba Medical College, KMC International Center, Manipal University, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shricharith","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Padmapriya","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathish","family":"Pai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250921","first-page":"237","article-title":"Bowen's disease","volume":"40","author":"Lee","year":"1990","journal-title":"CA-A Cancer Journal for Clinicians"},{"key":"R2-20250921","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1001\/archderm.1990.01670300077011","article-title":"Detection of human papillomavirus in nongenital Bowen's disease by in situ DNA hybridization","volume":"126","author":"Kettler","year":"1990","journal-title":"Arch Dermatol"},{"key":"R3-20250921","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1001\/archderm.1986.01660220042010","article-title":"Carcinoma arising in Bowen's disease","volume":"122","author":"Kao","year":"1986","journal-title":"Arch Dermatol"},{"key":"R4-20250921","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1001\/archderm.1960.01580030043005","article-title":"Association of Bowen's disease with visceral cancer","volume":"82","author":"Epstein","year":"1960","journal-title":"Arch Dermatol"},{"key":"R6-20250921","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1468-3083.2009.03337.x","article-title":"Expression of p53 and p16 in actinic keratosis, bowenoid actinic keratosis and Bowen's disease","volume":"24","author":"Bagazgoitia","year":"2010","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R7-20250921","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1046\/j.1365-2133.1999.03100.x","article-title":"Guidelines for management of Bowen\u203as disease. British associaton of dermatologists","volume":"141","author":"Cox","year":"1999","journal-title":"Br J Dermatol"},{"key":"R8-20250921","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1046\/j.1365-2168.1999.01184.x","article-title":"Outcome after surgical resection for high-grade anal intraepithelial neoplasia (Bowen's disease)","volume":"86","author":"Brown","year":"1999","journal-title":"Br J Surg"}],"container-title":["Indian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00076423-201459060-00058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:43:18Z","timestamp":1787067798000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00076423-201459060-00058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.4103\/0019-5154.143592","relation":{},"ISSN":["0019-5154","1998-3611"],"issn-type":[{"value":"0019-5154","type":"print"},{"value":"1998-3611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"2013-03-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-07-01","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}