{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:04:51Z","timestamp":1792854291140,"version":"4.5.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>Castleman's disease (CD) or giant lymph node hyperplasia is a rare disorder that can be unicentric or multicentric. Multicentric Castleman's disease (MCD) is manifested by generalized lymphadenopathy, hepatosplenomegaly, polyclonal hypergammaglobulinemia, hematological abnormality, and constitutional symptoms. Human herpesvirus 8 (HHV-8) infection is present in nearly 100% MCD associated with HIV-1 infection, but in about 50% of cases of HIV negative. Herein, we report a 77-year-old man with systemic involvement and skin lesions on the anterior aspect of both legs in the previous site of saphenous vein angioplasty. Co-existence of MCD with Kaposi's sarcoma (KS) led us to present this rare case.<\/jats:p>","DOI":"10.4103\/0019-5154.156457","type":"journal-article","created":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T02:33:56Z","timestamp":1430879636000},"page":"323-323","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Co-Existence of Multicentric Castleman's Disease and Kaposi's Sarcoma"],"prefix":"10.4103","volume":"60","author":[{"given":"Reza","family":"Yaghoobi","sequence":"first","affiliation":[{"name":"From the Department of Dermatology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader","family":"Pazyar","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadigheh","family":"Tavakoli","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250921","first-page":"3","article-title":"Multicentric Castleman's disease and Kaposi's sarcoma in a cyclosporin treated, HIV-1 negative patient: Case report","volume":"3","author":"Bollen","year":"2003","journal-title":"BMC Blood Disord"},{"key":"R2-20250921","doi-asserted-by":"crossref","first-page":"244","DOI":"10.4103\/0377-4929.64335","article-title":"Castleman's disease - 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