{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:19:07Z","timestamp":1787840347534,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>\n                    A 37-year-old male presented with severe oral and genital mucosal ulcers, lichenoid eruption and twenty-nail dystrophy. Systemic examination was normal, except for anemia. On investigations, he was found to have persistently elevated peripheral eosinophilia, absolute eosinophil count &gt;5000\/mm\n                    <jats:sup>3<\/jats:sup>\n                    , bone marrow showing increased eosinophilic precursors, and infiltration by atypical cells. The serum vitamin B12 levels were grossly elevated, and Philadelphia chromosome study was negative. Thus, a diagnosis of chronic eosinophilic leukemia was made. The patient showed excellent response to imatinib mesylate. We are reporting a rare type of leukemia presenting with predominantly cutaneous manifestations.\n                  <\/jats:p>","DOI":"10.4103\/0019-5154.185716","type":"journal-article","created":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T00:18:48Z","timestamp":1468282728000},"page":"437-439","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Chronic Eosinophilic Leukemia Presenting Predominantly with Cutaneous Manifestations"],"prefix":"10.4103","volume":"61","author":[{"given":"Suja","family":"Vidyadharan","sequence":"first","affiliation":[{"name":"From the Department of Dermatology and Venereology, Government Medical College, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bebisha","family":"Joseph","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology and Venereology, Government Medical College, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukumaran Pradeep","family":"Nair","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology and Venereology, Government Medical College, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250605","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s12288-008-0010-2","article-title":"Chronic eosinophilic leukemia: A case report and review of literature","volume":"23","author":"Kumar","year":"2007","journal-title":"Indian J Hematol Blood Transfus"},{"key":"R2-20250605","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.iac.2007.06.001","article-title":"Chronic eosinophilic leukemias and the myeloproliferative variant of the hypereosinophilic syndrome","volume":"27","author":"Bain","year":"2007","journal-title":"Immunol Allergy Clin North 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