{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:27:57Z","timestamp":1786728477543,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Xanthelasmoid or pseudoxanthomatous mastocytosis is an extremely rare variant of diffuse cutaneous mastocytosis. Herein, we describe an adult male with cutaneous mastocytosis showing multiple widespread yellowish ovoid papules like eruptive xanthoma. A 60-year-old male visited our outpatient clinic with a 1-year history of generalized yellowish, ovoid, and skin color papular eruption located on the trunk, groin, extremities, with the modest pruritus. Vital signs were stable, and Darier's sign was negative. No other subjective and objective signs were detected during the examination. No abnormality was detected in his diagnostic laboratory tests. Skin biopsy was taken, and histopathologic examination revealed proliferation of mast cells with ovoid and spindle nuclei with distinct cytoplasm borders around the capillaries, which was compatible with mastocytosis. Antihistamine was prescribed for pruritus control which was successful, but eruptions were persistent, and even 1-year phototherapy was not useful.<\/jats:p>","DOI":"10.4103\/0019-5154.185751","type":"journal-article","created":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T00:18:48Z","timestamp":1468282728000},"page":"468-468","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Adult Onset of Xanthelasmoid Mastocytosis: Report of a Rare Entity"],"prefix":"10.4103","volume":"61","author":[{"given":"Nafiseh Sadat","family":"Nabavi","sequence":"first","affiliation":[{"name":"From the Department of Dermatology, Cutaneous Leishmaniasis Research Center, Quaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masumeh Hosseini","family":"Nejad","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Cutaneous Leishmaniasis Research Center, Quaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahab","family":"Feli","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Cutaneous Leishmaniasis Research Center, Quaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnoosh","family":"Bakhshoodeh","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Cutaneous Leishmaniasis Research Center, Quaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pouran","family":"Layegh","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Cutaneous Leishmaniasis Research Center, Quaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250605","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1111\/j.1468-3083.2011.04350.x","article-title":"Diffuse cutaneous mastocytosis: Analysis of 10 cases and a brief review of the literature","volume":"26","author":"Lange","year":"2012","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R2-20250605","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1177\/0009922808318344","article-title":"Cutaneous mastocytosis: A review focusing on the pediatric population","volume":"47","author":"Briley","year":"2008","journal-title":"Clin Pediatr (Phila)"},{"key":"R3-20250605","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0145-2126(01)00044-3","article-title":"Clinical and histopathological aspects of cutaneous mastocytosis","volume":"25","author":"Wolff","year":"2001","journal-title":"Leuk Res"},{"issue":"3 Suppl","key":"R4-20250605","doi-asserted-by":"crossref","first-page":"15S","DOI":"10.1111\/1523-1747.ep12468942","article-title":"Pediatric mastocytosis","volume":"96","author":"Kettelhut","year":"1991","journal-title":"J Invest Dermatol"},{"key":"R5-20250605","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/bjd.13567","article-title":"Paediatric mastocytosis: A systematic review of 1747 cases","volume":"172","author":"M\u00e9ni","year":"2015","journal-title":"Br J Dermatol"},{"key":"R6-20250605","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1177\/095952878306600121","article-title":"On urticaria pigmentosa or xanthelasmoidea; urticaria pigmentosa (Sangster), U. 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