{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:34:49Z","timestamp":1787841289856,"version":"build-2784847793"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous disease resulting in a wide array of clinical manifestations, primarily affecting the skin and central nervous system. Mucocutaneous features play a very important role in the recognition of this syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To review the prevalence and patterns of cutaneous manifestations in tuberous sclerosis, in a group of patients from eastern India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Observational clinical study on twenty-seven consecutive patients of tuberous sclerosis collected during a period of four years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Most were between 10-20 years of age; the male to female ratio was 2:1. Family history was found in two-thirds. The classical triad of tuberous sclerosis was present in only nine (33.3%) patients. Adenoma sebaceum was the most common cutaneous feature (100%), followed by hypomelanotic macules (92.6%), connective tissue nevi (66.6%), and Koenen's tumors (33.3%). Oral mucosal fibromas were seen in six (22.22%) patients. Fibromatous plaque over forehead and scalp was seen in three patients. Limitation of the study was small size of study sample.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Prominent mucocutaneous changes are extremely common manifestation of TSC, which may provide crucial diagnostic clues for primary care physicians.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0019-5154.55636","type":"journal-article","created":{"date-parts":[[2009,9,10]],"date-time":"2009-09-10T06:30:03Z","timestamp":1252564203000},"page":"255-257","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["MUCOCUTANEOUS CHANGES IN TUBEROUS SCLEROSIS COMPLEX: A CLINICAL PROFILE OF 27 INDIAN PATIENTS"],"prefix":"10.4103","volume":"54","author":[{"given":"Sudip Kumar","family":"Ghosh","sequence":"first","affiliation":[{"name":"Departments of Dermatology, Venereology and Leprosy, R.G.Kar Medical College, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debabrata","family":"Bandyopadhyay","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Venereology and Leprosy, R.G.Kar Medical College, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gobinda","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Venereology and Leprosy, R.G.Kar Medical College, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arghyaprasun","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Venereology and Leprosy, R.G.Kar Medical College, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmila","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Medical College Calcutta, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somenath","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Venereology and Leprosy, R.G.Kar Medical College, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-20250920","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1177\/088307389801301206","article-title":"Tuberous sclerosis consensus conference: Revised clinical diagnostic criteria","volume":"13","author":"Roach","year":"1998","journal-title":"J Child Neurol"},{"key":"R3-20250920","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1097\/01.ju.0000058253.40352.60","article-title":"The tuberous sclerosis complex and its highly variable manifestations","volume":"169","author":"Lendvav","year":"2003","journal-title":"J Urol"},{"key":"R7-20250920","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1017\/S0012162206001058","article-title":"Tuberous sclerosis complex: Clinical features, diagnosis, and prevalence within Northern Ireland","volume":"48","author":"Devlin","year":"2006","journal-title":"Dev Med Child Neurol"},{"key":"R8-20250920","year":"2006","journal-title":"Andrew\u2032s Diseases of the Skin"},{"key":"R9-20250920","first-page":"239","article-title":"Tuberous sclerosis","volume":"62","author":"Krishnan","year":"1996","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"R11-20250920","doi-asserted-by":"crossref","first-page":"28","DOI":"10.4103\/0378-6323.38403","article-title":"Forehead plaque: A cutaneous marker of CNS involvement in tuberous sclerosis","volume":"74","author":"Rama Rao","year":"2008","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"R12-20250920","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.jaad.2006.11.019","article-title":"Oral findings in 58 adults with tuberous sclerosis complex","volume":"56","author":"Sparling","year":"2007","journal-title":"J Am Acad Dermatol"}],"container-title":["Indian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00076423-200954030-00012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:48:44Z","timestamp":1787838524000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00076423-200954030-00012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.4103\/0019-5154.55636","relation":{},"ISSN":["0019-5154","1998-3611"],"issn-type":[{"value":"0019-5154","type":"print"},{"value":"1998-3611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7]]},"assertion":[{"value":"2008-09-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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