{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:40:24Z","timestamp":1786650024044,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>This case describes a 42-year-old female with longstanding history of rheumatoid arthritis (RA) and Felty syndrome (FS). She presented with acute renal kidney failure, skin rash and hemoptysis. A clinical suspicion of small vessel vasculitis (SVV) was thought, serology was also positive for various markers of SVV. However, these serology markers could be false-positive in a patient of rheumatoid arthritis. A renal biopsy was performed that led to the final diagnosis of cryoglobulinemic vasculitis. Patient was managed according to the standard guidelines for therapy (plasmafiltration and immunosuppression). It is challenging to manage a patient of RA, in the presence of Felty syndrome-related granulocytopenia and thrombocytopenia. Patient initially showed signs of improvement, but finally succumbed to complications of therapy. The case provides insight into the diagnosis and management of such cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0022-3859.101642","type":"journal-article","created":{"date-parts":[[2012,9,26]],"date-time":"2012-09-26T20:40:02Z","timestamp":1348692002000},"page":"217-220","source":"Crossref","is-referenced-by-count":1,"title":["Female with rash, acute kidney failure and rheumatoid arthritis"],"prefix":"10.4103","volume":"58","author":[{"given":"M","family":"Atlani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Gandhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Gulwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20240205","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1046\/j.1440-1797.2003.00179.x","article-title":"Antineutrophil cytoplasmic antibody-negative pauci-immune crescentic glomerulonephritis associated with rheumatoid arthritis: An unusual case report","volume":"8","author":"Hsieh","year":"2003","journal-title":"Nephrology (Carlton"},{"key":"R2-15-20240205","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1002\/art.1780400417","article-title":"Perinuclear antineutrophil cytoplasmic antibody in rheumatoid arthritis: A marker of severe disease with associated nephropathy","volume":"40","author":"Mustila","year":"1997","journal-title":"Arthritis Rheum"},{"key":"R3-15-20240205","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0002-9343(74)90852-3","article-title":"Biologic and clinical significance of cryoglobulins. A report of 86 cases","volume":"57","author":"Brouet","year":"1974","journal-title":"Am J Med"},{"key":"R4-15-20240205","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S1473-3099(05)70053-0","article-title":"Hepatitis C virus, cryoglobulinaemia, and vasculitis: Immune complex relations","volume":"5","author":"Sansonno","year":"2005","journal-title":"Lancet Infect Dis"},{"key":"R5-15-20240205","doi-asserted-by":"crossref","first-page":"716","DOI":"10.3899\/jrheum.100898","article-title":"Clinical spectrum, treatment, and outcome of patients with type II mixed cryoglobulinemia without evidence of hepatitis C infection","volume":"38","author":"Foessel","year":"2011","journal-title":"J Rheumatol"},{"key":"R6-15-20240205","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/MD.0b013e3181c1750f","article-title":"Clinical and morphologic spectrum of renal involvement in patients with mixed cryoglobulinemia without evidence of hepatitis C virus infection","volume":"88","author":"Matignon","year":"2009","journal-title":"Medicine (Baltimore"},{"key":"R7-15-20240205","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/ki.1995.78","article-title":"Long-term predictors of survival in essential mixed cryoglobulinemic glomerulonephritis","volume":"47","author":"Tarantino","year":"1995","journal-title":"Kidney Int"},{"key":"R9-15-20240205","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.semarthrit.2006.08.005","article-title":"Life-threatening cryoglobulinemia: Clinical and immunological characterization of 29 cases","volume":"36","author":"Ramos-Casals","year":"2006","journal-title":"Semin Arthritis Rheum"},{"key":"R11-15-20240205","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.semarthrit.2003.10.001","article-title":"Mixed cryoglobulinemia: Demographic, clinical, and serologic features and survival in 231 patients","volume":"33","author":"Ferri","year":"2004","journal-title":"Semin Arthritis Rheum"},{"key":"R12-15-20240205","first-page":"83","article-title":"Double filtration plasmapheresis in the treatment of cryoglobulinemic glomerulonephritis","volume":"12","author":"Moriconi","year":"1989","journal-title":"Int J Art Org"},{"key":"R13-15-20240205","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1136\/ard.2006.065565","article-title":"Anti-CD20 monoclonal antibody (rituximab) treatment for cryoglobulinemic vasculitis: Where do we stand?","volume":"67","author":"Cacoub","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"R14-15-20240205","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0268-960X(96)90024-7","article-title":"Treatment of the neutropenia of Felty syndrome","volume":"10","author":"Rashba","year":"1996","journal-title":"Blood Rev"},{"key":"R15-15-20240205","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/ajh.2830430415","article-title":"Sequential administration of cyclophosphamide and granulocyte-colony stimulating factor relieves impaired myeloid maturation in Felty's syndrome","volume":"43","author":"Pixley","year":"1993","journal-title":"Am J Hematol"},{"key":"R16-15-20240205","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1002\/art.10497","article-title":"Autoantibodies against granulocyte colony-stimulating factor in Felty's syndrome and neutropenic systemic lupus erythematosus","volume":"46","author":"Hellmich","year":"2002","journal-title":"Arthritis Rheum"},{"key":"R17-15-20240205","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0272-6386(95)90095-0","article-title":"Cryoglobulinemic glomerulonephritis: A membranoproliferative glomerulonephritis induced by hepatitis C virus","volume":"25","author":"D'Amico","year":"1995","journal-title":"Am J Kidney Dis"}],"container-title":["Journal of Postgraduate Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00005257-201258030-00015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:01:11Z","timestamp":1786647671000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005257-201258030-00015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.4103\/0022-3859.101642","relation":{},"ISSN":["0022-3859"],"issn-type":[{"value":"0022-3859","type":"print"}],"subject":[],"published":{"date-parts":[[2012]]}}}