{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:37:36Z","timestamp":1786653456631,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Rechallenge with clozapine, despite a history of clozapine-induced neutropenia is considered in patients with a good response to the drug in the past, for whom no other treatments are effective, and in cases where the risks of withholding treatment are greater than the risks of rechallenge. Dyscrasias that occur during rechallenge are reportedly earlier in onset and longer lasting. Strategies advocated during rechallenge include frequent monitoring of white blood counts, the use of lithium or Granulocyte-Colony Stimulating Factors. We report a case of a patient with treatment-resistant schizophrenia who developed neutropenia with clozapine as a result of which the drug was discontinued. However poor response to other first and second-generation antipsychotic medication and the persisting risk of harm to himself and others necessitated the reconsideration of clozapine. The patient was re-challenged with clozapine under the cover of Filgrastim, a Granulocyte-Colony Stimulating Factor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0022-3859.109496","type":"journal-article","created":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T07:48:06Z","timestamp":1363938486000},"page":"54-55","source":"Crossref","is-referenced-by-count":11,"title":["Clozapine re-challenge under the cover of Filgrastim"],"prefix":"10.4103","volume":"59","author":[{"given":"R","family":"Gopalakrishnan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TP","family":"Subhalakshmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kuruvilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KS","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-11-20240205","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.schres.2011.10.014","article-title":"When can patients with potentially life-threatening adverse effects be rechallenged with clozapine? A systematic review of the published literature","volume":"134","author":"Manu","year":"2012","journal-title":"Schizophr Res"},{"key":"R2-11-20240205","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1176\/appi.ajp.2008.07111823","article-title":"Rechallenging with clozapine following neutropenia: Treatment options for refractory schizophrenia","volume":"165","author":"Ghaznavi","year":"2008","journal-title":"Am J Psychiatry"},{"key":"R3-11-20240205","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/01.yic.0000062800.74434.6c","article-title":"Long-term combination treatment with clozapine and filgrastim in patients with clozapine-induced agranulocytosis","volume":"18","author":"H\u00e4gg","year":"2003","journal-title":"Int Clin Psychopharmacol"},{"key":"R4-11-20240205","doi-asserted-by":"crossref","first-page":"756","DOI":"10.4088\/JCP.v67n0509","article-title":"Lithium and clozapine rechallenge: A retrospective case analysis","volume":"67","author":"Kanaan","year":"2006","journal-title":"J Clin Psychiatry"},{"key":"R5-11-20240205","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1007\/s11523-011-0190-9","article-title":"Presently available biosimilars in hematology-oncology: G-CSF","volume":"7","author":"Gascon","year":"2012","journal-title":"Target Oncol"},{"key":"R6-11-20240205","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1176\/ajp.2006.163.7.1298","article-title":"Reversible neutropenia with olanzapine following clozapine-induced neutropenia","volume":"163","author":"Thangadurai","year":"2006","journal-title":"Am J Psychiatry"},{"key":"R7-11-20240205","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1192\/bjp.188.3.255","article-title":"Rechallenge with clozapine following leucopenia or neutropenia during previous therapy","volume":"188","author":"Dunk","year":"2006","journal-title":"Br J Psychiatry"},{"key":"R8-11-20240205","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.4088\/JCP.11cr07263","article-title":"A case of agranulocytosis secondary to rechallenge with clozapine following severe neutropenia during previous therapy","volume":"72","author":"Lertxundi","year":"2011","journal-title":"J Clin Psychiatry"},{"key":"R9-11-20240205","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1176\/appi.ajp.2008.08081295","article-title":"Add-on filgrastim during clozapine rechallenge in patients with a history of clozapine-related granulocytopenia\/agranulocytosis","volume":"166","author":"Joffe","year":"2009","journal-title":"Am J Psychiatry"},{"key":"R10-11-20240205","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1097\/SMJ.0b013e318172f6c6","article-title":"Failure of filgrastim to prevent severe clozapine-induced agranulocytosis","volume":"101","author":"Majczenko","year":"2008","journal-title":"South Med J"}],"container-title":["Journal of Postgraduate Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00005257-201359010-00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:37:51Z","timestamp":1786649871000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005257-201359010-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.4103\/0022-3859.109496","relation":{},"ISSN":["0022-3859"],"issn-type":[{"value":"0022-3859","type":"print"}],"subject":[],"published":{"date-parts":[[2013]]}}}