{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:37:22Z","timestamp":1786653442896,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>A 55-year-old man treated with 5-fluorouracil and oxaliplatin for advanced sigmoid colon cancer presented with seizures, progressive gait and balance difficulties with frequent falls and slurring of speech. After three cycles of chemotherapy, brain magnetic resonance imaging using diffusion-weighted imaging clearly revealed the presence of high signal intensity in the deep white matter of the bilateral cerebral hemispheres, including the corpus callosum symmetrically. A diagnosis of acute leukoencephalopathy was made based on these findings. His clinical symptoms normalized after the discontinuation of the chemotherapy. Early detection of drug-induced leukoencephalopathy is important as the clinical symptoms can be reversed by early discontinuation of the causative drug. Diffusion-weighted magnetic resonance imaging is a useful modality for the early detection and definitive diagnosis of this characteristic encephalopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0022-3859.113845","type":"journal-article","created":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T06:07:48Z","timestamp":1371794868000},"page":"135-137","source":"Crossref","is-referenced-by-count":12,"title":["Diffusion weighted MR imaging of 5-fluorouracil and oxaliplatin-induced leukoencephalopathy"],"prefix":"10.4103","volume":"59","author":[{"given":"BS","family":"Paul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-11-20240205","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1056\/NEJM200108093450606","article-title":"Toxic leukoencephalopathy","volume":"345","author":"Filley","year":"2001","journal-title":"N Engl J Med"},{"key":"R2-11-20240205","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3747\/co.v15i5.252","article-title":"The confused cancer patient: A case of 5-fluorouracil-induced encephalopathy","volume":"15","author":"Cheung","year":"2008","journal-title":"Curr Oncol"},{"key":"R3-11-20240205","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1007\/s003300100955","article-title":"Diffusion weighted MR imaging of Calmofur-induced leukoencephalopathy","volume":"11","author":"Fujikawa","year":"2001","journal-title":"Eur Radiol"},{"key":"R4-11-20240205","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s00280-008-0876-6","article-title":"Central and peripheral nervous system toxicity of common chemotherapeutic agents","volume":"63","author":"Sioka","year":"2009","journal-title":"Cancer Chemothe rPharmacol"},{"key":"R5-11-20240205","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1212\/WNL.45.2.374","article-title":"Multifocal inflammatory leukoencephalopathy associated with levamisole therapy","volume":"45","author":"Kimmel","year":"1995","journal-title":"Neurology"},{"key":"R6-11-20240205","first-page":"477","article-title":"Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydroprymidine dehydrogenase deficiency","volume":"2","author":"Takimoto","year":"1996","journal-title":"Clin Cancer Res"},{"key":"R7-11-20240205","first-page":"1937","article-title":"Possible prediction of adverse reactions to pyrimidine chemotherapy from urinary pyrimidine levels and a case of asymptomatic adult dihydropyrimidinuria","volume":"2","author":"Hayashi","year":"1996","journal-title":"Clin Cancer Res"},{"key":"R8-11-20240205","first-page":"379","article-title":"Diffusion-weighted magnetic resonance imaging in early stage of 5-fluorouracil-induced leukoencephalopathy","volume":"106","author":"Tha","year":"2002","journal-title":"ActaNeurol Scand"},{"key":"R9-11-20240205","first-page":"415","article-title":"Cisplatin neurotoxicity presenting as reversible posterior leukoencephalopathy syndrome","volume":"19","author":"Ito","year":"1998","journal-title":"Am J Neuroradiol"},{"key":"R10-11-20240205","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1345\/aph.18425","article-title":"Fluorouracil-induced neurotoxicity","volume":"34","author":"Pirzada","year":"2000","journal-title":"Ann Pharmacother"}],"container-title":["Journal of Postgraduate Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00005257-201359020-00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:37:29Z","timestamp":1786649849000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005257-201359020-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.4103\/0022-3859.113845","relation":{},"ISSN":["0022-3859"],"issn-type":[{"value":"0022-3859","type":"print"}],"subject":[],"published":{"date-parts":[[2013]]}}}