{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:29:25Z","timestamp":1786649365544,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Vitamin D deficiency is widely prevalent in India and subjects who have almost no exposure to sunlight are severely deficient. Daily oral doses of cholecalciferol (vitamin D3) are costly as compared to stoss doses and further, take a long time for the serum levels to reach a plateau. Compliance to supplementation may also be better if a regimen involves single oral doses of vitamin D at specified intervals rather than daily doses. Evidence-based guidelines regarding the dosing and the frequency of dosing for prophylactic intermittent supplementation (stoss doses) in severely-deficient subjects are few.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>In a prospective intervention study, we serially assessed 30 asymptomatic healthy medical staff for serum 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH); (a) at baseline; (b) monthly for 3 months after single oral 60,000 units (U) cholecalciferol; (c) monthly for 3 months after 120,000 (or 180,000 for those with elevated alkaline phosphatase) U cholecalciferol; and, (d) subsequently, at 3 months after a repeat dose of 60,000 U cholecalciferol by repeated measures analysis of variance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The baseline serum 25(OH)D was 7.1 \u00b1 5.4 ng\/mL (&lt; 10 ng\/mL in 85% subjects) which increased to 18.7 \u00b1 8.9 ng\/mL at 1 month after 60,000 U of cholecalciferol (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and decreased to 11.1 \u00b1 5.3 ng\/mL by the 3\n                      <jats:sup>rd<\/jats:sup>\n                      month. The higher dose of 120,000 (or 180,000) U increased mean 25(OH)D to 28.9 \u00b1 9.9 ng\/mL at the end of 1\n                      <jats:sup>st<\/jats:sup>\n                      month, declining to 17.9 \u00b1 4.9 ng\/mL (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) at 3 months. With the subsequent 60,000 U the serum 25(OH)D was 18.4 \u00b1 3.9 ng\/mL at 3 months. PTH showed a corresponding negative trend. No hypercalcemia was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Vitamin D deficiency is highly prevalent amongst medical staff in Northern India. An initial dose of 120,000-180,000 U of cholecalciferol is required to elevate 25(OH)D out of the deficiency range. Maintenance dose is needed at 2 months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0022-3859.128812","type":"journal-article","created":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T08:11:44Z","timestamp":1394698304000},"page":"52-56","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Serum 25 hydroxyvitamin D profile after single large oral doses of cholecalciferol (vitamin D3) in medical staff in North India: A pilot study"],"prefix":"10.4103","volume":"60","author":[{"given":"L","family":"Priyambada","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Singh","sequence":"additional","affiliation":[{"name":"Dietetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250514","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1017\/S0007114507831758","article-title":"Vitamin D status of apparently healthy schoolgirls from two different socioeconomic strata in Delhi: Relation to nutrition and lifestyle","volume":"99","author":"Puri","year":"2008","journal-title":"Br J Nutr"},{"key":"R2-20250514","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/j.1365-2265.2008.03360.x","article-title":"Vitamin D deficiency in rural girls and pregnant women despite abundant sunshine in northern India","volume":"70","author":"Sahu","year":"2009","journal-title":"Clin Endocrinol"},{"key":"R3-20250514","first-page":"211","article-title":"Vitamin D status in Andhra Pradesh: A population based study","volume":"127","author":"Harinarayan","year":"2008","journal-title":"Indian J Med Res"},{"key":"R4-20250514","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1056\/NEJMe1206858","article-title":"Vitamin D-baseline status and effective dose","volume":"367","author":"Heaney","year":"2012","journal-title":"N Engl J Med"},{"key":"R5-20250514","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3390\/nu5010111","article-title":"Vitamin D - effects on skeletal and extra skeletal health and the need for supplementation","volume":"5","author":"Wacker","year":"2013","journal-title":"Nutrients"},{"key":"R6-20250514","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00198-005-1867-7","article-title":"Estimates of optimal vitamin D status","volume":"16","author":"Dawson-Hughes","year":"2005","journal-title":"Osteoporos Int"},{"key":"R7-20250514","doi-asserted-by":"crossref","first-page":"E1283","DOI":"10.1210\/jc.2013-1195","article-title":"Optimal Vitamin D Status: A critical analysis on the basis of evidence-based medicine","volume":"98","author":"Bouillon","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"R8-20250514","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1001\/archderm.1991.04510010104011","article-title":"Racial pigmentation and the cutaneous synthesis of vitamin D","volume":"127","author":"Matsuoka","year":"1991","journal-title":"Arch Dermatol"},{"key":"R9-20250514","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1210\/jc.2010-2704","article-title":"The 2011 report on dietary reference intakes for calcium and vitamin d from the institute of medicine: What clinicians need to know","volume":"96","author":"Ross","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"R10-20250514","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Endocrine Society. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"R11-20250514","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1093\/ajcn\/87.3.688","article-title":"Pharmacokinetics of a single, large dose of cholecalciferol","volume":"87","author":"Ilahi","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"R12-20250514","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1210\/jc.2008-0350","article-title":"Short and long-term variations in serum calciotropic hormones after a single very large dose of ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3) in the elderly","volume":"93","author":"Romagnoli","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"R13-20250514","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.1210\/jc.2010-0502","article-title":"Effect of a single oral dose of 600,000 IU of cholecalciferol on serum calciotropic hormones in young subjects with vitamin D deficiency: A prospective intervention study","volume":"95","author":"Cipriani","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"R14-20250514","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s11657-009-0026-8","article-title":"Effect of vitamin D supplementation on bone health parameters of healthy young Indian women","volume":"4","author":"Malhotra","year":"2009","journal-title":"Arch Osteoporos"},{"key":"R15-20250514","doi-asserted-by":"crossref","first-page":"399","DOI":"10.4158\/EP11268.OR","article-title":"Treatment with 50,000 IU vitamin D 2 every other week and effect on serum 25-hydroxyvitamin D 2, 25-hydroxyvitamin D 3, and total 25-hydroxyvitamin D in a clinical setting","volume":"18","author":"Demetriou","year":"2012","journal-title":"Endocr Pract"},{"key":"R16-20250514","doi-asserted-by":"crossref","first-page":"e1060","DOI":"10.1542\/peds.2011-1663","article-title":"Hypercalcemia in children receiving pharmacologic doses of vitamin D","volume":"129","author":"Vanstone","year":"2012","journal-title":"Pediatrics"},{"key":"R17-20250514","first-page":"118","article-title":"\u201cExcess gooD can be Dangerous\u201d. A case series of iatrogenic symptomatic hypercalcemia due to hypervitaminosis D","volume":"9","author":"Pandita","year":"2012","journal-title":"Clin Cases Miner Bone Metab"},{"key":"R18-20250514","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1001\/jama.2010.594","article-title":"Annual high-dose oral vitamin D and falls and fractures in older women: A randomized controlled trial","volume":"303","author":"Sanders","year":"2010","journal-title":"JAMA"}],"container-title":["Journal of Postgraduate Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00005257-201460010-00013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:53:11Z","timestamp":1786647191000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005257-201460010-00013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.4103\/0022-3859.128812","relation":{},"ISSN":["0022-3859","0972-2823"],"issn-type":[{"value":"0022-3859","type":"print"},{"value":"0972-2823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"2013-02-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-09-24","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}