{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:29:15Z","timestamp":1786649355534,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>\n                    Bristly luffa (\n                    <jats:italic toggle=\"yes\">Luffa echinata<\/jats:italic>\n                    ), a member of the cucurbitaceae family is an Ayurvedic medicinal plant, which has been used in the traditional system of medicine for variety of symptoms. The active constituents like cucurbitacin, saponin, echinatin, \u03b2-Sitosterol, oleanolic acid and flavonoids have important pathophysiological effects on human body. However, there is no earlier published report of any toxicity on humans. We report a case of a 50-year-old gentleman, who presented with gastrointestinal bleeding, deranged liver function and shock following consumption of dried fruits of\n                    <jats:italic toggle=\"yes\">Luffa echinata<\/jats:italic>\n                    soaked overnight in water. He had antral gastritis and duodenal erosions on upper gastrointestinal endoscopy and was managed conservatively and recovered completely.\n                  <\/jats:p>","DOI":"10.4103\/0022-3859.128819","type":"journal-article","created":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T08:11:44Z","timestamp":1394698304000},"page":"72-74","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Luffa echinata: Healer plant or potential killer?"],"prefix":"10.4103","volume":"60","author":[{"given":"S","family":"Giri","sequence":"first","affiliation":[{"name":"Department of Medicine, University College of Medical Sciences and Guru Tegh Bahadur Hospital, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CR","family":"Lokesh","sequence":"additional","affiliation":[{"name":"Department of Medicine, University College of Medical Sciences and Guru Tegh Bahadur Hospital, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sahu","sequence":"additional","affiliation":[{"name":"Department of Medicine, University College of Medical Sciences and Guru Tegh Bahadur Hospital, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Medicine, University College of Medical Sciences and Guru Tegh Bahadur Hospital, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R3-20250514","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0378-8741(00)00402-5","article-title":"Hepatoprotective activity of Luffa echinata fruits","volume":"76","author":"Ahmed","year":"2001","journal-title":"J Ethnopharmacol"},{"key":"R4-20250514","first-page":"904","article-title":"Colocynth toxicity. A possible cause of bloody diarrhea","volume":"24","author":"Khan","year":"2003","journal-title":"Saudi Med J"},{"key":"R5-20250514","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s12664-010-0009-0","article-title":"Hematemesis due to bitter melon (Momordica charantia) extract-induced gastric ulcerations","volume":"29","author":"Nadkarni","year":"2010","journal-title":"Indian J Gastroenterol"},{"key":"R6-20250514","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s12664-011-0110-z","article-title":"Gastrointestinal toxicity due to bitter bottle gourd (Lagenaria siceraria) - a report of 15 cases","volume":"30","author":"Puri","year":"2011","journal-title":"Indian J Gastroenterol"},{"key":"R7-20250514","doi-asserted-by":"crossref","first-page":"601682.","DOI":"10.1155\/2012\/601682","article-title":"Cucurbitacin B causes increased radiation sensitivity of human breast cancer cells via G2\/M Cell Cycle arrest","volume":"2012","author":"Duangmano","year":"2012","journal-title":"J Oncol"},{"key":"R10-20250514","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.freeradbiomed.2004.04.034","article-title":"Potential toxicity of flavonoids and other dietary phenolics: Significance for their chemo preventive and anticancer properties","volume":"37","author":"Galati","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"R11-20250514","doi-asserted-by":"crossref","first-page":"5780","DOI":"10.3390\/molecules17055780","article-title":"Luffa echinata Roxb. Induces human colon cancer cell (HT-29) death by triggering the mitochondrial apoptosis pathway","volume":"17","author":"Shang","year":"2012","journal-title":"Molecules"},{"key":"R12-20250514","first-page":"109","article-title":"Antiulcer activity ofaerial parts of Luffa Echinata Roxb. Ethanolic extracts in diclofenac sodium induced rats","volume":"3","author":"Kailasiya","year":"2012","journal-title":"Pharma Sci Monitor"},{"key":"R13-20250514","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3923\/jms.2012.99.106","article-title":"Evaluation of free Radical scavenging, Anti inflammatory and Analgesic potentials of Luffa Echinata seed extract","volume":"12","author":"Sharma","year":"2012","journal-title":"J Med Sci"},{"key":"R14-20250514","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2131\/jts.7.245","article-title":"The effects of echinatin and its related compounds on the mitochondrial energy transfer reaction","volume":"7","author":"Inoue","year":"1982","journal-title":"J Toxicol Sci"},{"key":"R15-20250514","first-page":"48","article-title":"Screening of Indian Plants for Biological Activity: Part XII","volume":"24","author":"Abraham","year":"1986","journal-title":"Indian J Exp Biol"}],"container-title":["Journal of Postgraduate Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00005257-201460010-00017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:53:02Z","timestamp":1786647182000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005257-201460010-00017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.4103\/0022-3859.128819","relation":{},"ISSN":["0022-3859","0972-2823"],"issn-type":[{"value":"0022-3859","type":"print"},{"value":"0972-2823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"2013-01-03","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-14","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}