{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:40:09Z","timestamp":1786653609586,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Ethyl alcohol exerts both positive and negative effects on the cardiovascular system. Alcoholic cardiomyopathy, produced by direct or indirect mechanisms, is well-documented. An important, but seldom appreciated effect is an increase in iron deposition in the myocardium, which can add to the cardiac dysfunction. The present study was planned to document the pathological features and iron levels in the cardiac tissue of patients who were chronic alcoholics and correlate these characteristics with the liver pathology and iron content.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>An autopsy-based prospective study of 40 consecutive patients compared with ten age matched controls (no history of alcohol intake). Histopathological changes like the morphology of the cardiac myocytes, degree of fibrosis (interstitial, interfiber, perivascular, and replacement), presence of inflammatory cells, increased capillary network, and adipose tissue deposition were noted and graded. These were also correlated with the liver pathology. The iron content in the heart and liver were measured by using calorimetry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>All cases had increased epicardial adipose tissue with epicardial and endocardial fibrosis, prominence of interstitial and interfiber fibrosis, myofiber degeneration, and increased capillary network; this was particularly prominent in patients with cirrhosis. Elemental iron level in heart tissue was raised in the cases relative to controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Alcohol produces subclinical changes in the myocardium, with an increased iron content, which may be the forerunner for subsequent clinical cardiac dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0022-3859.143958","type":"journal-article","created":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T05:57:41Z","timestamp":1415080661000},"page":"372-376","source":"Crossref","is-referenced-by-count":20,"title":["Cardiac pathology in chronic alcoholics"],"prefix":"10.4103","volume":"60","author":[{"given":"P","family":"Vaideeswar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Chaudhari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Rane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Gondhalekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Dandekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-5-20240205","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1378\/chest.121.5.1638","article-title":"Alcoholic cardiomyopathy. Incidence, clinical characteristics, and pathophysiology","volume":"121","author":"Piano","year":"2002","journal-title":"Chest"},{"key":"R3-5-20240205","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.3748\/wjg.v13.i37.4925","article-title":"Role of alcohol in the regulation of iron metabolism","volume":"13","author":"Harrison-Findik","year":"2007","journal-title":"World J Gastroenterol"},{"key":"R5-5-20240205","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jbbm.2003.11.003","article-title":"Microanalysis of non-heme iron in animal tissues","volume":"58","author":"Rebouche","year":"2004","journal-title":"J Biochem Biophys Methods"},{"key":"R6-5-20240205","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1093\/eurheartj\/eht246","article-title":"Interactions of the heart and the liver","volume":"34","author":"M\u00f8ller","year":"2013","journal-title":"Eur Heart J"},{"key":"R7-5-20240205","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.physbeh.2009.12.019","article-title":"Alcohol and cardiovascular health","volume":"100","author":"Klatsky","year":"2010","journal-title":"Physiol Behav"},{"key":"R8-5-20240205","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/eurjhf\/hfp037","article-title":"Alcohol abuse and heart failure","volume":"11","author":"Laonigro","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"R9-5-20240205","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.cardfail.2011.05.008","article-title":"Alcoholic cardiomyopathy: A review","volume":"17","author":"George","year":"2011","journal-title":"J Card Fail"},{"key":"R10-5-20240205","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF01908131","article-title":"Morphometric analysis of the rabbit myocardium after chronic ethanol feeding - early capillary changes","volume":"77","author":"Mall","year":"1982","journal-title":"Basic Res Cardiol"},{"key":"R11-5-20240205","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1177\/1753944708095137","article-title":"Mechanisms of alcoholic heart disease","volume":"2","author":"Ren","year":"2008","journal-title":"Ther Adv Cardiovasc Dis"},{"key":"R12-5-20240205","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s00392-013-0610-1","article-title":"Does cirrhotic cardiomyopathy exist? 50 years of uncertainty","volume":"102","author":"Pellicori","year":"2013","journal-title":"Clin Res Cardiol"},{"key":"R13-5-20240205","doi-asserted-by":"crossref","first-page":"8780","DOI":"10.1073\/pnas.151179498","article-title":"Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice","volume":"98","author":"Nicolas","year":"2001","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Journal of Postgraduate Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00005257-201460040-00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:39:55Z","timestamp":1786649995000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005257-201460040-00005"}},"subtitle":["A preliminary study"],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.4103\/0022-3859.143958","relation":{},"ISSN":["0022-3859"],"issn-type":[{"value":"0022-3859","type":"print"}],"subject":[],"published":{"date-parts":[[2014]]}}}