{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:23:24Z","timestamp":1787768604161,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) is a rare clinical entity that is easily missed due to lack of knowledge. It was formerly considered as a subset of rheumatoid arthritis (RA), but is now regarded as a distinct disease\/syndrome. The diagnosis of RS3PE is not easy, as it is always hindered by the lack of definite diagnostic criteria and presence of other much common rheumatological disorders that mimic it. We report a series of seven cases that attended our clinic in the last year, which highlight the salient features of the disease. The disease was found to have a heterogeneous presentation. Immunogenetic, clinical, laboratory, radiological, and possible etiological factors and associations with the neoplasm are described, as also other peculiar presentations. Finally, a comparison with other common rheumatological disorders is made to alert the clinician about this rare, but easily treatable disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0022-3859.147038","type":"journal-article","created":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T07:14:10Z","timestamp":1418627650000},"page":"38-41","source":"Crossref","is-referenced-by-count":23,"title":["Syndrome of remitting seronegative symmetrical synovitis with pitting edema"],"prefix":"10.4103","volume":"61","author":[{"given":"AN","family":"Varshney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NK","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-9-20240205","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1001\/jama.1985.03360190069027","article-title":"Remitting seronegative symmetrical synovitis with pitting edema.RS3PE syndrome","volume":"254","author":"McCarty","year":"1985","journal-title":"JAMA"},{"key":"R2-9-20240205","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1136\/ard.54.8.681","article-title":"Remitting seronegative symmetrical synovitis with pitting oedema: Disease or syndrome?","volume":"54","author":"Schaeverbeke","year":"1995","journal-title":"Ann Rheum Dis"},{"key":"R3-9-20240205","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.semarthrit.2008.03.008","article-title":"RS3PE presenting in a unilateral pattern: Case report and review of the literature","volume":"38","author":"Keenan","year":"2009","journal-title":"Semin Arthritis Rheum"},{"key":"R4-9-20240205","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.semarthrit.2010.09.001","article-title":"Unilateral RS3PE with young-onset rheumatoid arthritis","volume":"40","author":"Oz\u015fahin","year":"2011","journal-title":"Semin Arthritis Rheum"},{"key":"R5-9-20240205","first-page":"91","article-title":"Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome in Nagano, Japan: Clinical, radiological, and cytokine studies of 13 patients","volume":"22","author":"Oide","year":"2004","journal-title":"ClinExp Rheumatol"},{"key":"R6-9-20240205","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/01720610-201002000-00007","article-title":"Remitting seronegative symmetrical synovitis with pitting edema","volume":"23","author":"Sekhon","year":"2010","journal-title":"JAAPA"},{"key":"R7-9-20240205","first-page":"2","article-title":"Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome: A prospective follow up and ultrasound study","volume":"11","author":"Agarwal","year":"2003","journal-title":"J IndRheumatolAssoc"},{"key":"R8-9-20240205","first-page":"246","article-title":"Sarcoidosis with high serum levels of vascular endothelial growth factor (VEGF), showing RS3PE-like symptoms in extremities","volume":"23","author":"Matsuda","year":"2004","journal-title":"ClinRheumatol"},{"key":"R9-9-20240205","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.semarthrit.2008.11.006","article-title":"Is remitting seronegative symmetrical synovitis with pitting edema (RS3PE) a subset of rheumatoid arthritis?","volume":"40","author":"Yao","year":"2010","journal-title":"Semin Arthritis Rheum"},{"key":"R10-9-20240205","first-page":"71","article-title":"Remittingseronegative symmetrical synovitis with pitting edema","volume":"10","author":"Hartley","year":"2010","journal-title":"Grand Rounds"}],"container-title":["Journal of Postgraduate Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00005257-201561010-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:17:07Z","timestamp":1787768227000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005257-201561010-00009"}},"subtitle":["A case series"],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.4103\/0022-3859.147038","relation":{},"ISSN":["0022-3859"],"issn-type":[{"value":"0022-3859","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]}}}