{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:41:21Z","timestamp":1786653681686,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Improvements in medical facilities have helped a large number of clinically severe hemoglobin E (HbE)-\u03b2-thalassemia patients reach adulthood. Consequently, there is a new challenge, that of managing women with HbE-\u03b2-thalassemia during pregnancy. In particular, they have a high risk of abortion, preterm delivery, intrauterine growth restriction, and thromboembolism. A 27-year-old HbE-\u03b2-thalassemia patient on regular transfusion, who was splenectomized and heptatitis C (HCV)-positive, conceived for the first time without any infertility treatment. However, there was incomplete abortion with heavy bleeding at 3 months of gestation, which required bilateral uterine artery angiography. The angiogram showed the left uterine artery to be moderately hypertrophied. This was embolized with 300-500 micron polyvinyl alcohol (PVA) to stop the bleeding. Soon after, she conceived again with a twin pregnancy, and at 33.3 weeks of gestation, there was a normal delivery of twin girls without any postpartum hemorrhage or perineal tear. Both babies were given prematurity care. The mother and children were both normal up till the last follow-up 18 months after delivery, and both the girls are HbE heterozygous. Thorough monitoring of endocrine functions along with proper management of transfusions and iron overload can help in reducing the complications related to pregnancy in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0022-3859.159427","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T04:50:25Z","timestamp":1435294225000},"page":"203-205","source":"Crossref","is-referenced-by-count":5,"title":["A successful twin pregnancy in a patient with HbE-\u03b2-thalassemia in western India"],"prefix":"10.4103","volume":"61","author":[{"given":"R","family":"Merchant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Italia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RB","family":"Colah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-11-20240205","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bcmd.2008.08.003","article-title":"Hydroxyurea in sickle cell disease - A study of clinicopharmacological efficacy in the Indian haplotype","volume":"42","author":"Italia","year":"2009","journal-title":"Blood cells, Molecules and Diseases"},{"key":"R3-11-20240205","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cca.2009.06.019","article-title":"Response to Hydroxyurea in beta thalassemia major and intermedia: Experience in western India","volume":"407","author":"Italia","year":"2009","journal-title":"Clin Chim Acta"},{"key":"R4-11-20240205","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1136\/jcp.2009.070391","article-title":"Effect of hydroxyurea on the transfusion requirements in patients with severe HbE-beta-thalassemia: A genotypic and phenotypic study","volume":"63","author":"Italia","year":"2010","journal-title":"J Clin Pathol"},{"key":"R5-11-20240205","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1515\/JPEM.2000.13.2.179","article-title":"Iron deposition in the anterior pituitary in homozygous beta-thalassaemia: MRI evaluation and correlation with gonadal function","volume":"13","author":"Berkovitch","year":"2000","journal-title":"J Pediatr Endocrinol Metab"},{"key":"R6-11-20240205","first-page":"642","article-title":"Endocrine complications in patients with thalassaemia major","volume":"5","author":"Toumba","year":"2007","journal-title":"Pediatr Endocrinol Rev"},{"key":"R7-11-20240205","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3324\/haematol.2009.012393","article-title":"Pregnancy and beta-thalassemia: An Italian multicenter experience","volume":"95","author":"Origa","year":"2010","journal-title":"Haematologica"},{"key":"R8-11-20240205","first-page":"1187","article-title":"Survival of medically treated thalassemia patients in Cyprus. Trends and risk factors over the period 1980-2004","volume":"91","author":"Telfer","year":"2006","journal-title":"Haematologica"},{"key":"R9-11-20240205","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.3324\/haematol.13152","article-title":"Pregnancy outcome in patients with beta-thalassemia intermedia at two tertiary care centers, in Beirut and Milan","volume":"93","author":"Nassar","year":"2008","journal-title":"Haematologica"},{"key":"R10-11-20240205","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ijgo.2008.10.012","article-title":"Outcomes of pregnancies complicated by beta-thalassemia\/hemoglobin E disease","volume":"104","author":"Luewan","year":"2009","journal-title":"Int J Gynaecol Obstet"},{"key":"R11-11-20240205","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1080\/03014460802221121","article-title":"HbE genotypes and fertility: A study on a Tibeto-Burmese population in upper Assam, India","volume":"35","author":"Das","year":"2008","journal-title":"Ann Hum Biol"},{"key":"R13-11-20240205","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1177\/0091270009343933","article-title":"Exposure to hydroxyurea during pregnancy in sickle-beta thalassemia: A report of 2 cases","volume":"50","author":"Italia","year":"2010","journal-title":"J Clin Pharmacol"},{"key":"R15-11-20240205","doi-asserted-by":"crossref","first-page":"F156","DOI":"10.1136\/adc.2004.059436","article-title":"When does mother to child transmission of hepatitis C virus occur?","volume":"90","author":"Mok","year":"2005","journal-title":"Arch Dis Child Fetal Neonatal Ed"}],"container-title":["Journal of Postgraduate Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00005257-201561030-00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:40:45Z","timestamp":1786650045000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005257-201561030-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.4103\/0022-3859.159427","relation":{},"ISSN":["0022-3859"],"issn-type":[{"value":"0022-3859","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]}}}