{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:43:10Z","timestamp":1786653790731,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>The disorders of large granular lymphocytes include reactive proliferation as well as indolent or aggressive neoplasms of cytotoxic T cells, \u03b3\u03b4 T cells, and natural killer (NK) cells. They are associated with autoimmune and infectious disorders and have varied immunophenotypic features. We report a case, which highlights this complex association of autoimmune and infectious diseases with large granular lymphocytosis, the overlapping spectrum of large granular lymphocyte leukemias, and \u03b3\u03b4 T cell lymphomas as well as the difficulties in the diagnosis and management of these indolent T cell lymphomas in the usual clinical settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0022-3859.168739","type":"journal-article","created":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T06:08:06Z","timestamp":1446185286000},"page":"40-43","source":"Crossref","is-referenced-by-count":1,"title":["Persistent \u03b3\u03b4 T large granular lymphocytosis in a patient with refractory pure red cell aplasia, celiac disease, and chronic hepatitis B infection"],"prefix":"10.4103","volume":"62","author":[{"given":"S","family":"Sreedharanunni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MUS","family":"Sachdeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-7-20240205","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1365-2141.2010.08494.x","article-title":"Large granular lymphocytic leukaemia pathogenesis and management","volume":"152","author":"Dearden","year":"2011","journal-title":"Br J Haematol"},{"key":"R2-7-20240205","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1309\/A8FHDA0VVRJ05GJP","article-title":"T-cell large granular leukemia and related proliferations","volume":"127","author":"O'Malley","year":"2007","journal-title":"Am J Clin Pathol"},{"key":"R3-7-20240205","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.leukres.2007.04.011","article-title":"Clinical spectrum of gammadelta+ T cell LGL leukemia: Analysis of 20 cases","volume":"32","author":"Bourgault-Rouxel","year":"2008","journal-title":"Leuk Res"},{"key":"R4-7-20240205","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.revmed.2006.01.002","article-title":"Is pure red cell aplasia a new extra digestive manifestation of celiac disease?","volume":"27","author":"Couderc","year":"2006","journal-title":"Rev Med Interne"},{"key":"R5-7-20240205","first-page":"257","article-title":"Clinical evaluation of four cases of acute viral hepatitis complicated by pure red cell aplasia","volume":"89","author":"Ide","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"R7-7-20240205","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1053\/j.gastro.2012.08.028","article-title":"Large granular lymphocytic leukemia: A treatable form of refractory celiac disease","volume":"143","author":"Malamut","year":"2012","journal-title":"Gastroenterology"},{"key":"R8-7-20240205","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/BF00917105","article-title":"Lymphoproliferative disease of granular lymphocytes in a patient with concomitant hepatitis B virus infection of CD4 lymphocytes","volume":"9","author":"Agostini","year":"1989","journal-title":"J Clin Immunol"},{"key":"R9-7-20240205","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/sj.leu.2404112","article-title":"TCRgammadelta+ large granular lymphocyte leukemias reflect the spectrum of normal antigen-selected TCR gammadelta+ T-cells","volume":"20","author":"Sandberg","year":"2006","journal-title":"Leukemia"},{"key":"R10-7-20240205","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/cyto.b.20063","article-title":"Flow cytometric immunophenotypic profiles of mature gamma delta T-cell malignancies involving peripheral blood and bone marrow","volume":"67","author":"Ahmad","year":"2005","journal-title":"Cytometry B Clin Cytom"}],"container-title":["Journal of Postgraduate Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00005257-201662010-00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:42:23Z","timestamp":1786650143000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005257-201662010-00007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.4103\/0022-3859.168739","relation":{},"ISSN":["0022-3859"],"issn-type":[{"value":"0022-3859","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}