{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:34:16Z","timestamp":1788572056773,"version":"build-2803163510"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"abstract":"\n Context:<\/jats:title>\n \n Pro-inflammatory markers play a key role in the pathogenesis of various\n Flavivirus<\/jats:italic>\n infection.\n <\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n In this study, we evaluated the role of these markers in neurological manifestations of dengue.<\/jats:p>\n <\/jats:sec>\n \n Settings and Designs:<\/jats:title>\n Consecutive dengue cases with different neurological manifestations who presented between August 2012 and July 2014 were studied in hospital-based case\u2013control study.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n Interleukin (IL-6) and IL-8 level were measured in serum and cerebrospinal fluid (CSF) of dengue cases with different neurological manifestations and also in age- and sex-matched controls. Level was analyzed with various parameters and outcomes.<\/jats:p>\n <\/jats:sec>\n \n Statistical Analysis:<\/jats:title>\n \n Statistical analysis was done using SPSS version 16.0 by applying appropriate statistical methods.\n P<\/jats:italic>\n < 0.05 considered statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Out of the 40 enrolled cases of dengue with neurological manifestations, 29 had central nervous system and 11 had peripheral nervous system (CNS\/PNS) manifestations. In CNS group, both IL-6 and IL-8 (CSF and serum) were significantly elevated (\n P<\/jats:italic>\n < 0.001), whereas CSF IL-6 (\n P<\/jats:italic>\n = 0.008), serum IL-6 (\n P<\/jats:italic>\n = 0.001), and serum IL-8 (\n P<\/jats:italic>\n = 0.005) were significantly elevated in PNS group. CSF IL-6, serum IL-6, and IL-8 were significantly elevated in poor outcome patients in CNS group (\n P<\/jats:italic>\n < 0.05). CSF IL-6 and IL-8 were significantly elevated in CSF dengue positive cases as compared to CSF negative patients (\n P<\/jats:italic>\n < 0.05). Cytokine level was not significantly correlated with neuroimaging abnormality in CNS group. Nine patients died and the remainder recovered.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Elevated level of IL-6 and IL-8 is associated with different neurological manifestations and poor outcome, but whether they are contributing to neuropathogenesis or simply a correlate of severe disease remains to be determined.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/0022-3859.188545","type":"journal-article","created":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T03:04:51Z","timestamp":1471403091000},"page":"11-15","source":"Crossref","is-referenced-by-count":21,"title":["Study of interleukin-6 and interleukin-8 levels in patients with neurological manifestations of 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