{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:19:11Z","timestamp":1789460351737,"version":"build-2803163510"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Alzheimer's disease (AD) is a neurodegenerative disease, in which an accumulation of toxic amyloid beta in the brain precedes the emergence of clinical symptoms. AD spectrum consists of presymptomatic, early symptomatic, and symptomatic phase of dementia. At present, no pharmacotherapy exists to modify or reverse a course of AD, and only symptomatic treatments are available. Many elderly patients, diagnosed with multiple medical conditions (such as cardiovascular diseases, Type 2 diabetes mellitus, and cerebrovascular diseases) are at increased risk of the development of mild cognitive impairment (MCI), AD, and vascular dementia. Studies have revealed reduced rates of cognitive decline, in elderly patients, who were treated with centrally active angiotensin-converting enzyme inhibitors (ACE-Is) (that have an ability to cross the blood\u2013brain barrier). This article reviews recently published literature, focused on possible protective influence of the centrally active ACE-Is, in the elderly population, at risk for cognitive decline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0022-3859.188553","type":"journal-article","created":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T03:04:51Z","timestamp":1471403091000},"page":"242-248","source":"Crossref","is-referenced-by-count":45,"title":["Can angiotensin-converting enzyme inhibitors impact cognitive decline in early stages of Alzheimer's disease? An overview of research evidence in the elderly patient population"],"prefix":"10.4103","volume":"62","author":[{"given":"K","family":"Rygiel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-7-20240205","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1212\/01.wnl.0000228244.10416.20","article-title":"Mild cognitive impairment: Risk of Alzheimer disease and rate of cognitive decline","volume":"67","author":"Boyle","year":"2006","journal-title":"Neurology"},{"key":"R2-7-20240205","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1001\/jamaneurol.2015.3098","article-title":"Association of elevated amyloid levels with cognition and biomarkers in cognitively normal people from the community","volume":"73","author":"Petersen","year":"2016","journal-title":"JAMA 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