{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:27:01Z","timestamp":1786728421583,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Small cell neuroendocrine carcinoma (NEC) of the tongue is an extremely rare entity with only seven cases reported in literature till date. These are high-grade tumors with a dismal prognosis. There is much ambiguity regarding the classification, treatment protocols and prognostic factors of these tumors due to the paucity of studies. We describe an exceptionally rare and unusual case of small cell NEC of the base of tongue arising in an elderly man 6 years after receiving radiotherapy for the treatment of squamous cell carcinoma at the same site. The diagnosis was confirmed on histopathological examination and supported by immunohistochemical positivity for neuron-specific enolase, synaptophysin, chromogranin, pan-cytokeratin, and cytokeratin 7. To the best of our knowledge, this is the first case of intraoral NEC arising many years later within the irradiated field of the initial tumor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0022-3859.194209","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T01:54:23Z","timestamp":1479261263000},"page":"50-52","source":"Crossref","is-referenced-by-count":7,"title":["Postradiotherapy small cell neuroendocrine carcinoma of base of tongue"],"prefix":"10.4103","volume":"63","author":[{"given":"V","family":"Jha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AK","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AK","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20240205","doi-asserted-by":"crossref","first-page":"833","DOI":"10.3346\/jkms.2006.21.5.833","article-title":"Clinical overview of extrapulmonary small cell carcinoma","volume":"21","author":"Kim","year":"2006","journal-title":"J Korean Med Sci"},{"key":"R2-12-20240205","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1600-0714.2009.00834.x","article-title":"Neuroendocrine cells and associated malignancies of the oral mucosa: A review","volume":"39","author":"Mahomed","year":"2010","journal-title":"J Oral Pathol Med"},{"key":"R3-12-20240205","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1600-0714.1984.tb01449.x","article-title":"Extrapulmonary oat-cell carcinoma of the tongue: An electron-microscopic study","volume":"13","author":"Hull","year":"1984","journal-title":"J Oral Pathol"},{"key":"R4-12-20240205","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/0278-2391(95)90342-9","article-title":"Neuroendocrine carcinoma of the tongue: Report of a case","volume":"53","author":"Yoshida","year":"1995","journal-title":"J Oral Maxillofac Surg"},{"key":"R5-12-20240205","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.ijscr.2013.04.028","article-title":"Small cell neuroendocrine tumour of the anterior tongue: A case report","volume":"4","author":"Cymerman","year":"2013","journal-title":"Int J Surg Case Rep"},{"key":"R6-12-20240205","doi-asserted-by":"crossref","first-page":"181","DOI":"10.5005\/johcd-8-3-181","article-title":"Small cell neuroendocrine tumor of base of tongue - Treatment strategies of a rare entity","volume":"8","author":"Khurana","year":"2014","journal-title":"J Oral Health Community Dent"},{"key":"R7-12-20240205","doi-asserted-by":"crossref","first-page":"659","DOI":"10.4103\/0973-1482.139395","article-title":"Neuroendocrine carcinoma of the tongue","volume":"11","author":"Esmati","year":"2015","journal-title":"J Cancer Res Ther"},{"key":"R8-12-20240205","first-page":"7","article-title":"Primary small cell carcinoma of the tongue","volume":"S5","author":"Latif","year":"2012","journal-title":"J Cancer Sci Ther"},{"key":"R10-12-20240205","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2482\/haigan.55.9","article-title":"A case report of radiation-induced small cell lung cancer in the irradiation field for squamous cell carcinoma of the lung","volume":"55","author":"Tanaka","year":"2015","journal-title":"Haigan"}],"container-title":["Journal of Postgraduate Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00005257-201763010-00012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:26:51Z","timestamp":1786724811000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005257-201763010-00012"}},"subtitle":["An unusual clinical and site presentation"],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.4103\/0022-3859.194209","relation":{},"ISSN":["0022-3859"],"issn-type":[{"value":"0022-3859","type":"print"}],"subject":[],"published":{"date-parts":[[2017]]}}}