{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:18:07Z","timestamp":1787836687606,"version":"build-2784847793"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Septicemia is an important cause of neonatal morbidity and mortality. However, organized data on causative organisms and their resistant pattern are scanty from developing countries. The changing trend in causative organisms and their antibiotic resistance is yet to be documented in India. The present study examines the trends in bacterial profile and antibiotic resistance of the organisms causing sepsis in hospitalized neonates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A retrospective laboratory-based analysis of blood cultures obtained from Neonatal Intensive Care Unit of a tertiary care hospital in New Delhi was done for the period of 1999\u20132014, divided into five phases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 4700 isolates were considered. Over time, Gram-negative organisms have replaced Gram-positives as frequent isolates. Initially, there was predominance of\n                      <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                      , then of\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      which recently has been changed with coagulase negative-\n                      <jats:italic toggle=\"yes\">Staphylococcus<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Acinetobacter<\/jats:italic>\n                      . Growing resistance against the first and second line of drugs has been noted, including methicillin-resistant\n                      <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                      and vancomycin-resistant\n                      <jats:italic toggle=\"yes\">Enterococcus<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The etiological profile of neonatal sepsis has changed tremendously in the past 15 years. High resistance against common drugs necessitates continued surveillance and review of empirical antibiotic policy for neonatal sepsis. These steps are important to effectively curtail the surge of further antibiotic resistance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0022-3859.201425","type":"journal-article","created":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T03:32:52Z","timestamp":1499657572000},"page":"162-168","source":"Crossref","is-referenced-by-count":11,"title":["Changing trend in bacterial etiology and antibiotic resistance in sepsis of intramural neonates at a tertiary care hospital"],"prefix":"10.4103","volume":"63","author":[{"given":"MP","family":"Roy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Maurya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Arya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Gaind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HK","family":"Chellani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20240205","doi-asserted-by":"crossref","first-page":"483","DOI":"10.26719\/2000.6.2-3.483","article-title":"Blood-culture-proven neonatal septicaemia: A review of 36 cases","volume":"6","author":"Misallati","year":"2000","journal-title":"East Mediterr Health J"},{"key":"R2-6-20240205","doi-asserted-by":"crossref","first-page":"46","DOI":"10.7883\/yoken.JJID.2009.46","article-title":"Blood culture confirmed bacterial sepsis in neonates in a North Indian tertiary care center: Changes over the last decade","volume":"62","author":"Sundaram","year":"2009","journal-title":"Jpn J Infect Dis"},{"key":"R4-6-20240205","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1001\/jama.292.19.2357","article-title":"Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection","volume":"292","author":"Stoll","year":"2004","journal-title":"JAMA"},{"key":"R5-6-20240205","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3126\/jnps.v27i2.1411","article-title":"Clinical and bacteriological profiles of blood culture positive sepsis in newborns","volume":"27","author":"Shrestha","year":"2007","journal-title":"J Nepal Paediatr Soc"},{"key":"R6-6-20240205","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1056\/NEJMoa012657","article-title":"Changes in pathogens causing early-onset sepsis in very-low-birth-weight infants","volume":"347","author":"Stoll","year":"2002","journal-title":"N Engl J Med"},{"key":"R7-6-20240205","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.pcl.2012.12.003","article-title":"Neonatal infectious diseases: Evaluation of neonatal sepsis","volume":"60","author":"Camacho-Gonzalez","year":"2013","journal-title":"Pediatr Clin North Am"},{"key":"R8-6-20240205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/tropej\/fmu079","article-title":"Challenges in the diagnosis and management of neonatal sepsis","volume":"61","author":"Zea-Vera","year":"2015","journal-title":"J Trop Pediatr"},{"key":"R9-6-20240205","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1542\/peds.2005-0552","article-title":"Seventy-five years of neonatal sepsis at Yale:1928-2003","volume":"116","author":"Bizzarro","year":"2005","journal-title":"Pediatrics"},{"key":"R10-6-20240205","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3855\/jidc.625","article-title":"Neonatal septicemia isolates and resistance patterns in a tertiary care hospital of North India","volume":"4","author":"Kaistha","year":"2009","journal-title":"J Infect Dev Ctries"},{"key":"R11-6-20240205","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4103\/0974-2727.72156","article-title":"Bacteriologic profile and antibiogram of blood culture isolates in a pediatric care unit","volume":"2","author":"Prabhu","year":"2010","journal-title":"J Lab Physicians"},{"key":"R12-6-20240205","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ajic.2008.03.002","article-title":"CDC\/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting","volume":"36","author":"Horan","year":"2008","journal-title":"Am J Infect Control"},{"key":"R17-6-20240205","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.ijid.2008.08.020","article-title":"Etiology of neonatal blood stream infections in Tbilisi, Republic of Georgia","volume":"13","author":"Macharashvili","year":"2009","journal-title":"Int J Infect Dis"},{"key":"R18-6-20240205","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0140-6736(05)71881-X","article-title":"Hospital-acquired neonatal infections in developing countries","volume":"365","author":"Zaidi","year":"2005","journal-title":"Lancet"},{"key":"R19-6-20240205","first-page":"227","article-title":"Microbiological profile of neonatal septicemia in a pediatric care hospital in Delhi","volume":"37","author":"Kapoor","year":"2005","journal-title":"J Commun Dis"},{"key":"R21-6-20240205","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4103\/0019-557X.77264","article-title":"Profile and sensitivity pattern of bacteria isolated from various cultures in a tertiary care hospital in Delhi","volume":"54","author":"Tiwari","year":"2010","journal-title":"Indian J Public Health"},{"key":"R22-6-20240205","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/BF02752407","article-title":"Neonatal sepsis: Staphylococcus aureus as the predominant pathogen","volume":"68","author":"Karthikeyan","year":"2001","journal-title":"Indian J Pediatr"},{"key":"R23-6-20240205","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s12098-013-1314-2","article-title":"Blood culture isolates in neonatal sepsis and their sensitivity in Anand district of India","volume":"81","author":"Patel","year":"2014","journal-title":"Indian J Pediatr"},{"key":"R24-6-20240205","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/tropej\/fmp060","article-title":"Risk factors for extended-spectrum beta-lactamase producing Escherichia coli and Klebsiella pneumoniae acquisition in a neonatal Intensive Care Unit","volume":"56","author":"Shakil","year":"2010","journal-title":"J Trop Pediatr"},{"key":"R25-6-20240205","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s12098-010-0314-8","article-title":"Neonatal sepsis in a tertiary care hospital in South India: Bacteriological profile and antibiotic sensitivity pattern","volume":"78","author":"Zakariya","year":"2011","journal-title":"Indian J Pediatr"},{"key":"R26-6-20240205","first-page":"413","article-title":"Attributable mortality of imipenem-resistant nosocomial Acinetobacter baumannii bloodstream infection","volume":"92","author":"Jamulitrat","year":"2009","journal-title":"J Med Assoc Thai"},{"key":"R27-6-20240205","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4172\/jpb.1000248","article-title":"Molecular characterization and antimicrobial susceptibility study of Acinetobacter baumannii clinical isolates from middle East, African and Indian patients","volume":"5","author":"Chaudhary","year":"2012","journal-title":"J Proteomics Bioinform"},{"key":"R28-6-20240205","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0140-6736(05)71877-8","article-title":"WHO estimates of the causes of death in children","volume":"365","author":"Bryce","year":"2005","journal-title":"Lancet"},{"key":"R29-6-20240205","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/BF02727836","article-title":"Strategies which reduced sepsis-related neonatal mortality","volume":"55","author":"Singh","year":"1988","journal-title":"Indian J Pediatr"},{"key":"R30-6-20240205","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1179\/146532807X170501","article-title":"Extended-spectrum beta lactamase-producing gram-negative bacteria: Clinical profile and outcome in a neonatal Intensive Care Unit","volume":"27","author":"Sehgal","year":"2007","journal-title":"Ann Trop Paediatr"}],"container-title":["Journal of Postgraduate Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00005257-201763030-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:25:08Z","timestamp":1786724708000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005257-201763030-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.4103\/0022-3859.201425","relation":{},"ISSN":["0022-3859"],"issn-type":[{"value":"0022-3859","type":"print"}],"subject":[],"published":{"date-parts":[[2017]]}}}