{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:28:06Z","timestamp":1786649286119,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008]]},"abstract":"\n Context:<\/jats:title>\n The N-terminal pro-B type natriuretic peptide levels (NT pro-BNP) are increased in cases of volume or pressure overload.<\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n To examine NT pro-BNP levels and enclose whether any relationship is present between the levels of NT pro-BNP and extensive echocardiographic parameters in asymptomatic patients with mild to moderate aortic stenosis (AS).<\/jats:p>\n <\/jats:sec>\n \n Settings and Design:<\/jats:title>\n A cross-sectional study about the NT pro-BNP levels was conducted in 37 asymptomatic AS patients and compared with 40 controls.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Patients <70 years old with mild to moderate AS with a peak transaortic gradient <20 mm Hg in transthoracic echocardiogram were included in our study. Extensive echocardiographic parameters and NT pro-BNP levels were obtained from these patients and these indices were compared with the control population selected from the patients who had similar clinical characteristics with the AS patients.<\/jats:p>\n <\/jats:sec>\n \n Statistical Analysis:<\/jats:title>\n NT-proBNP values were found to be distribution free. Spearman correlation coefficient was used for correlation analysis. Mean values were compared by the Kruskal-Wallis test.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The NT pro-BNP levels were increased in patients with AS (median; interquartiles range: 686 [449-855] pg\/mL vs. 140 [116-150] pg\/mL,\n P<\/jats:italic>\n < 0.001). Among patients with AS, when correlation analysis was performed mean transaortic gradient, aortic valve area index, myocardial performance index, E\n m<\/jats:sub>\n \/A\n m<\/jats:sub>\n ratio, left-ventricular mass index (LVMI) and E\/E\n m<\/jats:sub>\n ratio had correlations (r=0.38,\n P<\/jats:italic>\n = 0.026; r=-0.46,\n P<\/jats:italic>\n =0.008; r=0.19,\n P<\/jats:italic>\n =0,049; r=-0.22,\n P<\/jats:italic>\n =0.04, r=0.49,\n P<\/jats:italic>\n =0.003 and r=0.53,\n P<\/jats:italic>\n <0.001 respectively) with plasma NT pro-BNP levels. The LVMI (r = 0.49,\n P<\/jats:italic>\n = 0.003) and E\/E\n m<\/jats:sub>\n ratio (r = 0.53\n P<\/jats:italic>\n < 0.001) have the strongest correlations when compared to other parameters.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Plasma NT pro-BNP levels are increased in even asymptomatic patients with AS and correlated with several echocardiographic parameters related to severity of AS and degree of diastolic dysfunction. As a result, NT pro-BNP levels may be used in the follow-up of asymptomatic patients having mild to moderate AS.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/0022-3859.39183","type":"journal-article","created":{"date-parts":[[2009,2,9]],"date-time":"2009-02-09T03:08:48Z","timestamp":1234148928000},"page":"12-16","source":"Crossref","is-referenced-by-count":15,"title":["Relationship between N-terminal pro-B type natriuretic peptide and extensive echocardiographic parameters in mild to moderate aortic 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