{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:17:35Z","timestamp":1787771855582,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Hypereosinophilic syndrome (HES) is classically defined as prolonged, unexplained peripheral eosinophilia in a patient presenting with evidence of end-organ damage. The heart is involved in two forms; endomyocardial fibrosis (Davies disease) and eosinophilic endocarditis (Loffler's endocarditis). It was first reported in 1968 by Hard and Anderson. Chusid and co-workers formulated a definition with strict criteria for the diagnosis of HES as 1) peripheral blood eosinophilia more than 1500 cells\/cu mm for at least six months duration 2)signs, symptoms of end-organ (heart, lungs, gastrointestinal tract, skin, bone-marrow, brain) involvement with eosinophil tissue infiltration\/injury 3) exclusion of known secondary causes of eosinophilia. We report a case of hypereosinophilic syndrome with Loffler's endocarditis, in the absence of endomyocardial fibrosis. The patient presented with a eosinophilic vegetation over the posterior leaflet of the mitral valve. There was complete resolution of the vegetation after two months of corticosteroid therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0022-3859.40780","type":"journal-article","created":{"date-parts":[[2009,2,9]],"date-time":"2009-02-09T03:08:58Z","timestamp":1234148938000},"page":"135-137","source":"Crossref","is-referenced-by-count":13,"title":["Hypereosinophilic syndrome with isolated Loeffler\u2032s endocarditis"],"prefix":"10.4103","volume":"54","author":[{"given":"T","family":"Sen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CK","family":"Ponde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZF","family":"Udwadia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-16-20240205","doi-asserted-by":"crossref","first-page":"e635","DOI":"10.1161\/CIRCULATIONAHA.106.636753","article-title":"Early differential resolution of right and left ventricular obliteration in Loffler's endocarditis","volume":"114","author":"Benezet-Mazuecos","year":"2006","journal-title":"Circulation"},{"key":"R2-16-20240205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005792-197501000-00001","article-title":"The hypereosinophilic syndrome: Analysis of fourteen cases with review of literature","volume":"54","author":"Chusid","year":"1975","journal-title":"Medicine [Baltimore"},{"key":"R3-16-20240205","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1136\/adc.62.6.601","article-title":"The idiopathic hypereosinophilic syndrome","volume":"62","author":"Alfaham","year":"1987","journal-title":"Arch Dis Child"},{"key":"R4-16-20240205","first-page":"668","article-title":"Loeffler endomyocarditis: A clinical presentation as right ventricular tumor","volume":"6","author":"De Cock","year":"1998","journal-title":"J Heart Valve Dis"},{"key":"R5-16-20240205","doi-asserted-by":"crossref","first-page":"78","DOI":"10.7326\/0003-4819-97-1-78","article-title":"The idiopathic hypereosinophilic syndrome: Clinical, pathologic and therapeutic considerations: NIH conference","volume":"97","author":"Fauci","year":"1982","journal-title":"Ann Intern Med"},{"key":"R6-16-20240205","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/S0003-4975(10)64701-7","article-title":"Aortic and mitral valve replacement in Idiopathic hypereosinophilic syndrome","volume":"46","author":"Hendren","year":"1988","journal-title":"Ann Thorac Surg"},{"key":"R7-16-20240205","doi-asserted-by":"crossref","first-page":"167","DOI":"10.7326\/0003-4819-89-2-167","article-title":"Therapy of the hypereosinophilic syndrome","volume":"89","author":"Parillo","year":"1978","journal-title":"Ann Intern Med"},{"key":"R8-16-20240205","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1398-9995.1982.tb02339.x","article-title":"The hypereosinophilic syndrome: Clinical features, laboratory findings and treatment","volume":"37","author":"Spry","year":"1982","journal-title":"Allergy"},{"key":"R9-16-20240205","first-page":"65","article-title":"The hypereosinophilic syndrome: Case report","volume":"52","author":"Mikolajczyk","year":"2006","journal-title":"Ann Acad Med Stetin"},{"key":"R10-16-20240205","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s11239-007-0029-5","article-title":"Unusual case of aortic valve involvement in patient with Loffler's endomyocarditis: Management follow-up and short review of literature","volume":"24","author":"Bozcali","year":"2007","journal-title":"J Thom Thrombolysis"}],"container-title":["Journal of Postgraduate Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00005257-200854020-00016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:17:57Z","timestamp":1787768277000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005257-200854020-00016"}},"subtitle":["Complete resolution with corticosteroids"],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.4103\/0022-3859.40780","relation":{},"ISSN":["0022-3859"],"issn-type":[{"value":"0022-3859","type":"print"}],"subject":[],"published":{"date-parts":[[2008]]}}}