{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:28:45Z","timestamp":1786649325926,"version":"build-2736575974"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Alkaptonuria is a rare autosomal recessive metabolic disorder that may present with multi-system involvement such as ochronotic arthropathy, renal, urethral and prostatic calculi, cardiac valvular lesions and pigmentation of the skin, sclera, cartilage and other connective tissues. An association of the disease with uveitis has never been reported. We report the first case of alkaptonuria with ochronotic arthropathy presenting with recurrent acute anterior uveitis as the initial manifestation. The possible common link with the HLA-B27 gene is discussed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0022-3859.48438","type":"journal-article","created":{"date-parts":[[2009,2,26]],"date-time":"2009-02-26T23:35:16Z","timestamp":1235691316000},"page":"35-37","source":"Crossref","is-referenced-by-count":12,"title":["Acute anterior uveitis as the initial presentation of alkaptonuria"],"prefix":"10.4103","volume":"55","author":[{"given":"SS","family":"John","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Padhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JV","family":"Mathews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-9-20240205","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/BF01450903","article-title":"Clinical, radiographic and echocardiographic findings in a patient with ochronosis","volume":"17","author":"Ko\u03b7yigit","year":"1998","journal-title":"Clin Rheumatol"},{"key":"R2-9-20240205","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/BF02208354","article-title":"Spinal abnormalities similar to ankylosing spondylitis in a 58-year-old woman with ochronosis","volume":"14","author":"Kabasakal","year":"1995","journal-title":"Clin Rheumatol"},{"key":"R3-9-20240205","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.survophthal.2005.04.003","article-title":"Acute anterior uveitis and HLA-B27","volume":"50","author":"Chang","year":"2005","journal-title":"Surv Ophthalmol"},{"key":"R4-9-20240205","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3121\/cmr.2.4.209","article-title":"Alkaptonuric ochronosis with aortic valve and joint replacements and femoral fracture: A case report and literature review","volume":"2","author":"Fisher","year":"2004","journal-title":"Clin Med Res"},{"key":"R5-9-20240205","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1056\/NEJMoa021736","article-title":"Natural history of alkaptonuria","volume":"347","author":"Phornphutkul","year":"2002","journal-title":"N Engl J Med"},{"key":"R6-9-20240205","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1007\/s10067-005-0038-8","article-title":"Ochronotic spondyloarthropathy: Spinal involvement resembling ankylosing spondylitis","volume":"25","author":"Balaban","year":"2006","journal-title":"Clin Rheumatol"},{"key":"R7-9-20240205","first-page":"1707","article-title":"Coexistence of ochronosis and ankylosing spondylitis","volume":"17","author":"Gemignani","year":"1990","journal-title":"J Rheumatol"},{"key":"R8-9-20240205","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0002-9394(14)72165-8","article-title":"Outcomes of HLA-B27-positive and HLA-B27-negative acute anterior uveitis","volume":"120","author":"Linssen","year":"1995","journal-title":"Am J Ophthalmol"}],"container-title":["Journal of Postgraduate Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00005257-200955010-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:52:29Z","timestamp":1786647149000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005257-200955010-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.4103\/0022-3859.48438","relation":{},"ISSN":["0022-3859"],"issn-type":[{"value":"0022-3859","type":"print"}],"subject":[],"published":{"date-parts":[[2009]]}}}