{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:28:47Z","timestamp":1786649327738,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>We present a rare but potentially harmful adverse reaction of propofol. A 50-year-old patient was posted for laparoscopic cholecystectomy, developed generalized convulsions after few seconds of propofol administration at anesthesia induction. Convulsions subsided with intravenous administrations of thiopentone and midazolam. Patient remained hemodynamically stable and surgery was uneventful. Blood sugar, serum electrolytes and arterial blood gas analysis were normal. Postoperatively, there was no evidence of postictal phase, serum electrolytes and postoperative computerized tomographic scanning of the head were normal. Patient had uneventful recovery. The administration of propofol has been associated with abnormal movements collectively termed as seizure-like phenomenon. Despite the claims that propofol may have proconvalsant activity, there is significant amount of evidence to the contrary also. The pathophysiological mechanisms behind the neuroexcitatory symptoms with propofol are unknown. Propofol alters the conscious state, the transition from the conscious state to anesthesia or vice versa may be a particularly vulnerable period and may be prolonged after the end of propofol administration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0022-3859.48444","type":"journal-article","created":{"date-parts":[[2009,2,26]],"date-time":"2009-02-26T23:35:16Z","timestamp":1235691316000},"page":"69-71","source":"Crossref","is-referenced-by-count":5,"title":["Convulsions with propofol"],"prefix":"10.4103","volume":"55","author":[{"given":"R","family":"Garg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Dehran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-16-20240205","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1034\/j.1399-6576.2000.440203.x","article-title":"Severe neuroexcitatory symptoms after anaesthesia-with focus on propofol anaesthesia","volume":"44","author":"Islander","year":"2000","journal-title":"Acta Anaesthesiol Scand"},{"key":"R2-16-20240205","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/bja\/82.2.199","article-title":"Effect of propofol on the electrocorticogram in epileptic patients undergoing cortical resection","volume":"82","author":"Hewitt","year":"1999","journal-title":"Br J Anaesth"},{"key":"R3-16-20240205","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1212\/WNL.58.9.1327","article-title":"Seizure like phenomenon and Propofol: A systematic review","volume":"58","author":"Walder","year":"2002","journal-title":"Neurology"},{"key":"R4-16-20240205","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/bja\/76.4.570","article-title":"Unilateral convulsion after induction of anaesthesia with propofol","volume":"76","author":"Cochran","year":"1996","journal-title":"Br J Anaesth"},{"key":"R5-16-20240205","first-page":"45","article-title":"Propofol induced myoclonus may dislodge laryngeal mask airway","volume":"50","author":"Rath","year":"2006","journal-title":"Indian J Anaesth"},{"key":"R6-16-20240205","first-page":"420","article-title":"Jankovic J. Propofol induced dyskinesias in parkinson's disease","volume":"83","author":"Krauss","year":"1996","journal-title":"Anesth Analg"},{"key":"R7-16-20240205","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1007\/BF03011977","article-title":"Is propofol anticonvulsant or proconvulsant?","volume":"44","author":"Baraka","year":"1997","journal-title":"Can J Anaesth"},{"key":"R8-16-20240205","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/00008506-200104000-00005","article-title":"Propofol versus methohexital for electroconvulsive therapy","volume":"13","author":"Walder","year":"2001","journal-title":"J Neurosurg Anesthesiol"},{"key":"R9-16-20240205","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/j.0013-9580.2004.01904.x","article-title":"Propofol treatment of refractory status epilepticus: A study of 31 episodes","volume":"45","author":"Rossetti","year":"2004","journal-title":"Epilepsia"},{"key":"R10-16-20240205","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1111\/j.1365-2044.2006.04782.x","article-title":"Effect of propofol on seizure like phenomenon and electroencephalographic activity in children with epilepsy vs children with learning difficulties","volume":"61","author":"Meyer","year":"2006","journal-title":"Anaesthesia"},{"key":"R11-16-20240205","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s005400300009","article-title":"Seizure induced by a small dose of fentanyl","volume":"17","author":"Fujimoto","year":"2003","journal-title":"J Anesth"},{"key":"R12-16-20240205","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1212\/01.WNL.0000032253.88378.D7","article-title":"High dose thiopental in the treatment of refractory status epilepticus in intensive care unit","volume":"59","author":"Parvianen","year":"2002","journal-title":"Neurology"},{"key":"R13-16-20240205","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2165\/00148581-200709020-00006","article-title":"Generalized seizures following topical lidocaine administration during circumcision: Establishing causation","volume":"9","author":"Rezvani","year":"2007","journal-title":"Paediatr Drugs"}],"container-title":["Journal of Postgraduate Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00005257-200955010-00016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:52:31Z","timestamp":1786647151000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005257-200955010-00016"}},"subtitle":["A rare adverse event"],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.4103\/0022-3859.48444","relation":{},"ISSN":["0022-3859"],"issn-type":[{"value":"0022-3859","type":"print"}],"subject":[],"published":{"date-parts":[[2009]]}}}