{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:11:15Z","timestamp":1789726275396,"version":"4.0.1"},"reference-count":4,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Many drugs are implicated in causation of disulfiram-like reaction. The disulfiram-like reaction can vary in severity and can occasionally be fatal. The reaction is believed to result from inhibition of metabolism of acetaldehyde to acetate by inhibition of aldehyde dehydrogenase. The increase in serum acetaldehyde results in unpleasant clinical manifestations. Metronidazole is known to cause disulfiram-like reaction. Although no previous report has implicated ornidazole in causation of disulfiram-like reaction, caution has been advised with the use of all imidazoles. We report the case of a 48-year-old male, who was taking ornidazole and developed features of disulfiram-like reaction after taking alcohol. The patient was managed with supportive measures and improved. The report highlights the need for clinicians to advise patients to restrict intake of alcohol if they are being prescribed imidazole derivatives.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0022-3859.58940","type":"journal-article","created":{"date-parts":[[2010,2,8]],"date-time":"2010-02-08T00:47:14Z","timestamp":1265590034000},"page":"292-293","source":"Crossref","is-referenced-by-count":12,"title":["Disulfiram-like reaction with ornidazole"],"prefix":"10.4103","volume":"55","author":[{"given":"V","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-18-20240205","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/10915810701583010","article-title":"Pharmaceutical agents known to produce disulfiram-like reaction: Effects on hepatic ethanol metabolism and brain monoamines","volume":"26","author":"Karamanakos","year":"2007","journal-title":"Int J Toxicol"},{"key":"R3-18-20240205","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/00000433-199612000-00013","article-title":"Sudden death due to metronidazole\/ethanol interaction","volume":"17","author":"Cina","year":"1996","journal-title":"Am J Forensic Med Pathol"},{"key":"R4-18-20240205","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1345\/aph.1A066","article-title":"Lack of disulfiram-like reaction with metronidazole and ethanol","volume":"36","author":"Visap\u00e4\u00e4","year":"2002","journal-title":"Ann Pharmacother"},{"key":"R5-18-20240205","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/clpt.1981.154","article-title":"A method for estimating the probability of adverse drug reactions","volume":"30","author":"Naranjo","year":"1981","journal-title":"Clin Pharmacol Ther"}],"container-title":["Journal of Postgraduate Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00005257-200955040-00018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:56:31Z","timestamp":1786647391000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005257-200955040-00018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":4,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.4103\/0022-3859.58940","relation":{},"ISSN":["0022-3859"],"issn-type":[{"value":"0022-3859","type":"print"}],"subject":[],"published":{"date-parts":[[2009]]}}}