{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:10:28Z","timestamp":1793059828600,"version":"4.5.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010]]},"abstract":"\n Background:<\/jats:title>\n Primary hyperparathyroidism (PHPT) has a variable clinical presentation and symptomatic PHPT is still the predominant form of the disease in India. Data from western India is lacking.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n To present the clinical profile of PHPT from western India.<\/jats:p>\n <\/jats:sec>\n \n Settings and Design:<\/jats:title>\n This retrospective study was conducted at a tertiary care referral center.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n We analyzed the clinical presentation, biochemical, radiological features, and operative findings in adult patients with PHPT (1986-2008) and compared with our published data of children and adolescent patients with PHPT.<\/jats:p>\n <\/jats:sec>\n \n Statistical Analysis:<\/jats:title>\n was done with SPSS 16 software.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Seventy-nine patients (F: M-2:1) with age ranging from 21 to 55 years (mean 33.5\u00b18.82) were analyzed. Skeletal manifestations (75.5%), renal calculi (40.5%) and proximal muscle weakness (45.5%) were the most common symptoms of presentation with mean duration of symptoms being 33.70 (median: 24, range 1-120) months. Biochemical features included hypercalcemia (total corrected calcium 12.55\u00b11.77 mg\/dl), low inorganic phosphorus (1.81\u00b10.682 mg\/dl), elevated total alkaline phosphatase (mean: 762.2; median: 559; range: 50-4930IU\/L) and high parathyroid hormone (PTH) (mean\u00b1SD: 866.61\u00b1799.15; median: 639.5; range: 52-3820 pg\/ml). Preoperative localization was achieved in 74 patients and single adenoma was found during surgery in 72 patients. Hungry bone disease was seen in 30.3% and transient hypoparathyroidism developed in 62% patients. In comparison to PHPT in children there were no significant differences with regard to clinical, laboratory and radiological features.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n PHPT in western India is symptomatic disorder with skeletal and renal mani-festations at a much younger age. Clinical profile of PHPT in children is similar to that of adults.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/0022-3859.65279","type":"journal-article","created":{"date-parts":[[2010,7,8]],"date-time":"2010-07-08T07:28:15Z","timestamp":1278574095000},"page":"79-84","source":"Crossref","is-referenced-by-count":56,"title":["Clinical profile of primary hyperparathyroidism from western India"],"prefix":"10.4103","volume":"56","author":[{"given":"RA","family":"Gopal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SV","family":"Acharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Bandgar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PS","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AN","family":"Dalvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NS","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20240205","doi-asserted-by":"crossref","first-page":"433","DOI":"10.7326\/0003-4819-126-6-199703150-00003","article-title":"The rise and fall of primary hyperparathyrodism: A population-based study in Rochester, Minnesota, 1965-1992","volume":"126","author":"Wermers","year":"1997","journal-title":"Ann Intern Med"},{"key":"R2-6-20240205","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1056\/NEJM198001243020402","article-title":"Primary hyperparathyrodism. 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A South Indian experience and a review of published work","volume":"76","author":"Jacob","year":"2006","journal-title":"ANZ J Surg"},{"key":"R17-6-20240205","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1445-2197.1998.tb04719.x","article-title":"Pancreatitis and primary hyperparathyroidism: forty cases","volume":"68","author":"Carnaille","year":"1998","journal-title":"Aust N Z J Surg"},{"key":"R18-6-20240205","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s12098-009-0289-5","article-title":"Primary hyperparathyroidism in children and adolescents","volume":"77","author":"George","year":"2010","journal-title":"Indian J Pediatr"},{"key":"R19-6-20240205","first-page":"N44","article-title":"Primary hyperparathyroidism in children and adolescents: the Johns Hopkins Children's Center experience 1984-2001","volume":"17","author":"Hsu","year":"2002","journal-title":"J Bone Miner Res"},{"key":"R20-6-20240205","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1056\/NEJM198001243020402","article-title":"Primary hyperparathyroidism: incidence, morbidity and potential economic impact in a community","volume":"302","author":"Heath","year":"1980","journal-title":"N Eng J Med"},{"key":"R21-6-20240205","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1093\/qjmed\/89.12.921","article-title":"Primary hyperparathyroidism in a paediatric hospital","volume":"89","author":"Lawson","year":"1996","journal-title":"QJM"}],"container-title":["Journal of Postgraduate Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00005257-201056020-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:17:36Z","timestamp":1787768256000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005257-201056020-00006"}},"subtitle":["A single center experience"],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.4103\/0022-3859.65279","relation":{},"ISSN":["0022-3859"],"issn-type":[{"value":"0022-3859","type":"print"}],"subject":[],"published":{"date-parts":[[2010]]}}}