{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:17:33Z","timestamp":1787771853044,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Scorpion venoms cause a massive release of neurotransmitters. Either anti-scorpion venom serum (AScVS) or prazosin has been used in the management of severe scorpion envenomation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To compare the time taken for clinical recovery by patients with severe scorpion envenomation after AScVS therapy with that following prazosin therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings and Design:<\/jats:title>\n                    <jats:p>A prospective, open-labeled clinical trial was undertaken to compare the effects of the AScVS and\/or prazosin on clinical recovery in scorpion-stung patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Eighty-one patients from rural districts of Maharashtra presenting with severe scorpion envenomation were assigned to three treatment groups (AScVS: n = 28; prazosin: n = 25; AScVS + prazosin: n = 28). Severity of scorpion envenomation was graded using a proposed composite clinical scoring system to assess the therapeutic efficacy. AScVS was administered as an intravenous slow bolus, ranging from 40 to 100 ml, depending on the severity of envenomation. Prazosin was given as 1 mg every 3 h.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis Used:<\/jats:title>\n                    <jats:p>\n                      The non-parametric \"Kruskal-Wallis\" test was used in the statistical analysis and a\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      -value of 0.05 was considered significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mean composite scores of patients from the three groups at the time of admission were comparable. Complete clinical recovery was noted in 4.14 \u00b1 1.6 h and 19.28 \u00b1 5.03 h in the subjects who were administered AScVS and prazosin, respectively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). There was no incidence of anaphylactic reaction to AScVS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Intravenous slow bolus of AScVS given based on the clinical severity of envenomation leads to early recovery than prazosin alone and is well tolerated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0022-3859.70938","type":"journal-article","created":{"date-parts":[[2010,10,7]],"date-time":"2010-10-07T04:58:33Z","timestamp":1286427513000},"page":"275-280","source":"Crossref","is-referenced-by-count":35,"title":["Efficacy of anti-scorpion venom serum over prazosin in the management of severe scorpion envenomation"],"prefix":"10.4103","volume":"56","author":[{"given":"VS","family":"Natu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SB","family":"Kamerkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Geeta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Vidya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Natu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Kushte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Thatte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DA","family":"Uchil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NN","family":"Rege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RD","family":"Bapat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-8-20240205","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0090-4295(03)00785-4","article-title":"Nitric oxide release from human corpus cavernosum induced by a purified scorpion toxin","volume":"63","author":"Teixeira","year":"2004","journal-title":"Urology"},{"key":"R2-8-20240205","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1590\/S0104-79302000000100002","article-title":"The Scorpion Envenoming Syndrome: A different perspective. The physiological basis of the role of insulin in the scorpion envenoming. Review article","volume":"6","author":"Krishna Murthy","year":"2000","journal-title":"J Venom Anim Toxins"},{"key":"R3-8-20240205","first-page":"85","article-title":"Preparation of potent antiscorpion venom serum against the venom of the scorpion (Buthus tamulus)","volume":"44","author":"Kankonkar","year":"1998","journal-title":"J Postgrad Med"},{"key":"R4-8-20240205","doi-asserted-by":"crossref","first-page":"277","DOI":"10.4269\/ajtmh.1995.52.277","article-title":"Efficacy of antivenom therapy for neutralizing circulating venom antigens in patients stung by Tityus serrulatus scorpions","volume":"52","author":"De Rezende","year":"1995","journal-title":"Am J Trop Med Hyg"},{"key":"R5-8-20240205","doi-asserted-by":"crossref","first-page":"277","DOI":"10.4269\/ajtmh.2000.62.277","article-title":"Scorpion envenomation and serotherapy in Morocco","volume":"62","author":"Ghalim","year":"2000","journal-title":"Am J Trop Med Hyg"},{"key":"R6-8-20240205","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0035-9203(03)00062-2","article-title":"Epidemiological data, clinical admission gradation and biological quantification by ELISA of scorpion envenomation in Algeria: effect of immunotherapy","volume":"98","author":"Hammoudi-Triki","year":"2004","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"R7-8-20240205","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0041-0101(97)00136-0","article-title":"Development of an Elisa for the detection of scorpion venoms in sera of humans envenomed by androctonus australis garzonii (AAG) and buthus occitanus tunetanus (BOT): correlation with clinical severity of envenoming in Tunisia","volume":"36","author":"Krifi","year":"1998","journal-title":"Toxicon"},{"key":"R8-8-20240205","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0140-6736(98)12083-4","article-title":"Serotherapy in scorpion envenomation: a randomized controlled trial","volume":"354","author":"Abroug","year":"1999","journal-title":"Lancet"},{"key":"R9-8-20240205","first-page":"14","article-title":"Utility of Scorpion Antivenin vs Prazosin in the management of severe Mesobuthus tamulus (Indian Red Scorpion) envenomation at rural Setting","volume":"55","author":"Bawaskar","year":"2007","journal-title":"JAPI"},{"key":"R10-8-20240205","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0022-3476(05)83196-8","article-title":"Scorpion envenomation and antivenom therapy","volume":"124","author":"Sofer","year":"1994","journal-title":"J Pediatrics"},{"key":"R11-8-20240205","first-page":"283","article-title":"Efficacy of species specific Anti-scorpion venom serum(AScVS) against severe, serious scorpion stings (Mesobuthus tamulus concanesis Pocock)-An experience from Rural hospital in Western Maharashtra","volume":"54","author":"Natu","year":"2006","journal-title":"JAPI"},{"key":"R12-8-20240205","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0041-0101(97)00062-7","article-title":"Pharmacokinetics of 125I-labelled Walterinnesia aegyptia venom and its specific antivenins: flash absorption and distribution of the venom and its toxin versus slow absorption and distribution of IgG, F(ab\u2032)2 and F(ab) of the antivenin","volume":"36","author":"Ismail","year":"1998","journal-title":"Toxicon"},{"key":"R13-8-20240205","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/02724936.1991.11747506","article-title":"Scorpion sting in children in the Jerusalem area: a review of 54 cases","volume":"11","author":"Dudlin","year":"1991","journal-title":"Ann Trop Pediatr"},{"key":"R14-8-20240205","first-page":"1175","article-title":"Prazosin therapy and scorpion envenomation","volume":"48","author":"Bawaskar","year":"2000","journal-title":"JAPI"},{"key":"R15-8-20240205","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/0041-0101(94)90383-2","article-title":"Scorpionism and serotherapy in Mexico","volume":"32","author":"Dehesa-Davila","year":"1994","journal-title":"Toxicon"},{"key":"R16-8-20240205","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/0041-0101(95)00005-7","article-title":"The scorpion envenoming syndrome. Review Article","volume":"33","author":"Ismail","year":"1995","journal-title":"Toxicon"},{"key":"R17-8-20240205","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1056\/NEJMoa0808455","article-title":"Antivenom for critically ill children with neurotoxicity from scorpion stings","volume":"360","author":"Boyer","year":"2009","journal-title":"N Engl J Med"},{"key":"R18-8-20240205","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1331\/JAPhA.2007.07051","article-title":"Treatment of Yellow Scorpion (Leiurus quinquesriatus) sting: A case report","volume":"47","author":"Shelita Eric","year":"2007","journal-title":"J Am Pharm Assoc"},{"key":"R19-8-20240205","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/BF02759921","article-title":"Outcome of scorpion sting envenomation after a protocol guided therapy","volume":"73","author":"Biswal","year":"2006","journal-title":"Indian J Pediatr"},{"key":"R20-8-20240205","first-page":"301","article-title":"A retrospective analysis of a rural set up experience with special reference to dobutamine in prazosin resistant scorpion sting cases","volume":"57","author":"Patil","year":"2009","journal-title":"JAPI"},{"key":"R21-8-20240205","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/tropej\/fmp070","article-title":"Management of scorpion sting: prazosin or dobutamine","volume":"56","author":"Gupta","year":"2010","journal-title":"J Trop Pediatr"},{"key":"R22-8-20240205","first-page":"22","article-title":"Captopril in the treatment of cardiovascular manifestations of Indian red scorpion (Mesobuthus tamulus concanesis pocock) envenomation","volume":"55","author":"Krishnan","year":"2007","journal-title":"JAPI"},{"key":"R23-8-20240205","first-page":"299","article-title":"Management of scorpion envenomation: Need for a standard treatment protocol using drugs and antivenom","volume":"57","author":"Karnad","year":"2009","journal-title":"JAPI"},{"key":"R24-8-20240205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0104-79301999000200002","article-title":"The improvement and standardization of antivenom production in developing countries: Comparing antivenom quality, therapeutical efficiency and cost. Review article","volume":"5","author":"Krifi","year":"1999","journal-title":"J Venom Anim Toxins"},{"key":"R25-8-20240205","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1177\/0960327109350667","article-title":"Severe scorpion envenomation in children: Management in pediatric intensive care unit","volume":"28","author":"Bosnak","year":"2009","journal-title":"Hum Exp Toxicol"},{"key":"R26-8-20240205","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1590\/S0104-79301999000100003","article-title":"99m Tc-scorpion venom: labeling, biodistribution and scinti-imaging","volume":"5","author":"Murugesan","year":"1999","journal-title":"J Venom Anim Toxins"}],"container-title":["Journal of Postgraduate Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00005257-201056040-00008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:17:54Z","timestamp":1787768274000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005257-201056040-00008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.4103\/0022-3859.70938","relation":{},"ISSN":["0022-3859"],"issn-type":[{"value":"0022-3859","type":"print"}],"subject":[],"published":{"date-parts":[[2010]]}}}