{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:29:13Z","timestamp":1786649353190,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,1]]},"abstract":"\n Background:<\/jats:title>\n \n To improve the empiric antimicrobial therapy of community-acquired (CA) skin and soft tissue infections (SSTIs), it is necessary to generate data on the current spectrum and susceptibility profile of associated bacteria. CA methicillin-resistant\n Staphylococcus aureus<\/jats:italic>\n (CA MRSA) is increasingly being reported in SSTIs in India and globally.\n <\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n \n The present study was undertaken to determine the bacterial profile of CA-SSTIs, to know the contribution of MRSA in these infections, to determine inducible clindamycin resistance in\n S<\/jats:italic>\n .\n aureus<\/jats:italic>\n and to compare the resistance patterns of isolates from hospital-acquired (HA) SSTIs.\n Materials and Methods<\/jats:bold>\n : Eight hundred and twenty patients with CA SSTIs were prospectively studied. Pus samples were cultured and antimicrobial susceptibility pattern determined. Inducible clindamycin resistance was detected by D-test. Laboratory records were analyzed retrospectively to generate data on HA SSTIs.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n 619 isolates were recovered in CA-SSTIs, of which\n S<\/jats:italic>\n .\n aureus<\/jats:italic>\n (73%) and\n Streptococci<\/jats:italic>\n (12%) were the most common.\n Pseudomonas aeruginosa<\/jats:italic>\n (28%) and\n Acinetobacter spp<\/jats:italic>\n (18%) were the predominant HA-SSTI pathogens. Susceptibility of CA\n S<\/jats:italic>\n .\n aureus<\/jats:italic>\n to antibiotics tested was, penicillin (6%), co-trimoxazole (20%), ciprofloxacin (37%), cefazolin (100%), erythromycin (84%), clindamycin (97%), gentamicin (94%) and fusidic acid (95%). No MRSA was found in CA SSTIs whereas 45% of HA\n S<\/jats:italic>\n .\n aureus<\/jats:italic>\n strains were methicillin-resistant. HA strains demonstrated significantly higher resistance as compared to their CA counterparts (\n P<\/jats:italic>\n <0.001). D test was positive in 22% of CA\n S<\/jats:italic>\n .\n aureus<\/jats:italic>\n tested.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n \n In CA SSTIs, methicillin-susceptible\n S<\/jats:italic>\n .\n aureus<\/jats:italic>\n is the predominant pathogen. Penicillinase-resistant penicillins, clindamycin and erythromycin in that order can be used as suitable antimicrobials for empiric therapy. D test should be carried out routinely. No CA MRSA was detected in the present series.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/0022-3859.93245","type":"journal-article","created":{"date-parts":[[2012,2,25]],"date-time":"2012-02-25T03:30:45Z","timestamp":1330140645000},"page":"3-7","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["Is methicillin-resistant Staphylococcus aureus involved in community acquired skin and soft tissue infections?"],"prefix":"10.4103","volume":"58","author":[{"given":"RS","family":"Phakade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Nataraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SK","family":"Kuyare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"US","family":"Khopkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PR","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-2-20250320","first-page":"62","article-title":"Cellulitis, skin abscesses and community-acquired methicillin-resistant Staphylococcus aureus.","volume":"6","author":"Auwaerter","year":"2006","journal-title":"Johns Hopkins Advanced Studies in Medicine"},{"key":"R2-2-20250320","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/QCO.0b013e32805dfb2d","article-title":"Acute bacterial skin infections and cellulitis","volume":"20","author":"Gabillot-Carr\u00e9","year":"2007","journal-title":"Curr Opin Infect Dis"},{"key":"R3-2-20250320","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1086\/497143","article-title":"Infectious Diseases Society of America. 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