{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:29:10Z","timestamp":1786649350814,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,1]]},"abstract":"\n \n Clinical involvement of the peripheral nervous system in the calcinosis cutis, raynaud's phenomenon, esophageal dismotility, sclerodactyly and telangiectasia (CREST) variant of systemic sclerosis occurs infrequently and is characterized by axonal degeneration due to necrotizing vasculitis. We report a female patient with a known history of CREST syndrome, which developed a slowly progressive, distal symmetric demyelinating sensorimotor polyneuropathy (PN), with tremor and ataxia as prominent features, compatible with anti-myelin associated glycoprotein (MAG) PN. The diagnosis of PN was established by the presence of monoclonal immunoglobulin M anti-MAG antibodies (Thin-Layer Chromatography, Western Blot and enzyme-linked immunoabsorbent assay). Given the evidence that in CREST activation of T-helper cells is observed and that anti-MAG antibodies, despite the fact that they are T-cell-independent, may be influenced by an increase in T-helper function, the coexistence of these two rare autoimmune disorders in the same patient may not be incidental but related to the underlying immunological mechanisms involved.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/0022-3859.93254","type":"journal-article","created":{"date-parts":[[2012,2,25]],"date-time":"2012-02-25T03:30:45Z","timestamp":1330140645000},"page":"57-59","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Anti-myelin-associated glycoprotein polyneuropathy coexistent with CREST syndrome"],"prefix":"10.4103","volume":"58","author":[{"given":"E","family":"Andreadou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Zouvelou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Karandreas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Kilidireas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20250320","first-page":"942","article-title":"Vasculitis in systemic sclerosis: Association with Sj\u00f6grens syndrome and the CREST syndrome variant","volume":"14","author":"Oddis","year":"1987","journal-title":"J Rheumatol"},{"key":"R2-10-20250320","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1212\/WNL.49.6.1641","article-title":"A case control and nerve biopsy study of CREST multiple mononeuropathy","volume":"49","author":"Dyck","year":"1997","journal-title":"Neurology"},{"key":"R3-10-20250320","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1097\/01.wco.0000245368.36576.0d","article-title":"Anti-myelin-associated glycoprotein neuropathy","volume":"19","author":"Steck","year":"2006","journal-title":"Curr Opin Neurol"},{"key":"R4-10-20250320","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1212\/WNL.37.11.1795","article-title":"Neuropathy and IgM paraproteinemia: Differential binding of IgM M-proteins to peripheral nerve glycolipids","volume":"37","author":"Kusunoki","year":"1987","journal-title":"Neurology"},{"key":"R5-10-20250320","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1212\/WNL.40.7.1067","article-title":"The spectrum of neurologic disease associated with anti-GMl antibodies","volume":"40","author":"Sadiq","year":"1990","journal-title":"Neurology"},{"key":"R6-10-20250320","first-page":"S5","article-title":"A working classification of scleroderma spectrum disorders: A proposal and the results of testing on a sample of patients","volume":"22","author":"Maricq","year":"2004","journal-title":"Clin Exp Rheumatol"},{"key":"R7-10-20250320","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ncl.2006.11.003","article-title":"Chronic inflammatory demyelinating polyneuropathy","volume":"25","author":"Lewis","year":"2007","journal-title":"Neurol Clin"},{"key":"R8-10-20250320","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1093\/brain\/124.10.1968","article-title":"The clinical and laboratory features of chronic sensory ataxic neuropathy with anti-disialosyl IgM antibodies","volume":"124","author":"Willison","year":"2001","journal-title":"Brain"},{"key":"R9-10-20250320","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0889-857X(05)70296-9","article-title":"Immunopathogenesis of systemic sclerosis","volume":"22","author":"White","year":"1996","journal-title":"Rheum Dis Clin North Am"},{"key":"R10-10-20250320","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/ana.410180204","article-title":"Neuropathy and anti-myelin-associated glycoprotein IgM M proteins: T cell regulation of M protein secretion in vitro","volume":"18","author":"Latov","year":"1985","journal-title":"Ann Neurol"}],"container-title":["Journal of Postgraduate Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00005257-201258010-00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:52:57Z","timestamp":1786647177000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005257-201258010-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.4103\/0022-3859.93254","relation":{},"ISSN":["0022-3859"],"issn-type":[{"value":"0022-3859","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}