{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:21:29Z","timestamp":1787775689542,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Lymphomatoid granulomatosis (LYG) is a rare lymphoproliferative disease characterized by angiocentric and angiodestructive infiltrate. It primarily affects the lung and sometimes may also affect the central nervous system (CNS), skin, kidney, liver, etc., but the involvement of lymph nodes and\/or bone marrow is extremely rare, and if present, other diagnoses are usually considered. Isolated CNS involvement is very rare, and its pathogenesis and biological behavior have been controversially discussed. Here, we report a 46-year-old man with diffuse and symmetrical corpus callosum involvement. The histopathological findings were in keeping with LYG. Since there was no evidence of involvement of other organs, he was diagnosed with primary CNS-LYG. He responded well to steroids and his symptoms improved significantly. We also conduct an English literature review to provide clues for the diagnosis and treatment of this disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0028-3886.314578","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T01:30:50Z","timestamp":1619400650000},"page":"497-499","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Primary Central Nervous System Lymphomatoid Granulomatosis Presenting as Diffuse Corpus Callosum Lesions"],"prefix":"10.4103","volume":"69","author":[{"given":"Yuanyuan","family":"Xiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinjian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-58-20240907","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/PAS.0000000000000328","article-title":"Lymphomatoid granulomatosis--A single institute experience: Pathologic findings and clinical correlations","volume":"39","author":"Song","year":"2015","journal-title":"Am J Surg Pathol"},{"key":"R2-58-20240907","doi-asserted-by":"crossref","first-page":"W1","DOI":"10.2214\/AJR.11.8080","article-title":"Lesions of the corpus callosum","volume":"200","author":"Ho","year":"2013","journal-title":"AJR Am J Roentgenol"},{"key":"R3-58-20240907","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.neurad.2012.12.001","article-title":"MR imaging of the brain and spinal cord in lymphomatoid granulomatosis: A case report and review of the literature","volume":"40","author":"Gaha","year":"2013","journal-title":"J Neuroradiol"},{"key":"R4-58-20240907","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/cns.12414","article-title":"Lymphomatoid granulomatosis with central nervous system involvement successfully treated with cyclophosphamide, high-dose cytarabine, dexamethasone, etoposide, and rituximab (CHASER therapy) followed by brain irradiation: A case study","volume":"21","author":"Fujimaki","year":"2015","journal-title":"CNS Neurosci Ther"},{"key":"R5-58-20240907","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11060-008-9771-6","article-title":"A case of central nervous system lymphomatoid granulomatosis; characteristics of PET imaging and pathological findings","volume":"93","author":"Nishihara","year":"2009","journal-title":"J Neurooncol"},{"key":"R6-58-20240907","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/1097-0142(197901)43:1<360::AID-CNCR2820430151>3.0.CO;2-8","article-title":"Lymphomatoid granulomatosis: A clinicopathologic study of 152 cases","volume":"43","author":"Katzenstein","year":"1979","journal-title":"Cancer"},{"key":"R7-58-20240907","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0140-6736(12)60069-5","article-title":"Adult primary central nervous system vasculitis","volume":"380","author":"Salvarani","year":"2012","journal-title":"Lancet"},{"key":"R8-58-20240907","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1182\/blood.V72.5.1674.1674","article-title":"Angiocentric immunoproliferative lesions: A clinicopathologic spectrum of post-thymic T-cell proliferations","volume":"72","author":"Lipford","year":"1988","journal-title":"Blood"},{"key":"R9-58-20240907","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1182\/blood.2019000933","article-title":"Pathobiology and treatment of lymphomatoid granulomatosis; A rare EBV-driven disorder","volume":"135","author":"Melani","year":"2020","journal-title":"Blood"},{"key":"R10-58-20240907","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1182\/blood.V87.11.4531.bloodjournal87114531","article-title":"Association of lymphomatoid granulomatosis with Epstein-Barr viral infection of B lymphocytes and response to interferon-alpha 2b","volume":"87","author":"Wilson","year":"1996","journal-title":"Blood"}],"container-title":["Neurology India"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.314578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:39:07Z","timestamp":1787773147000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.314578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/0028-3886.314578","relation":{},"ISSN":["0028-3886"],"issn-type":[{"value":"0028-3886","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]}}}