{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:45:15Z","timestamp":1792806315434,"version":"4.5.0"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Migraine is a common neurological disorder with significant morbidity and disability. There is growing evidence that migraine is associated with cardiovascular diseases and stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study was to provide an update on the association of migraine with some common vascular diseases in persons suffering from the disease and discuss the clinical implications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Materials:<\/jats:title>\n                    <jats:p>We searched PUBMED database using the MeSH terms \u201cStroke\u201d, \u201cCoronary Artery Disease\u201d, \u201cMyocardial Ischemia\u201d, \u201cAtrial Fibrillation\u201d, \u201cWhite Matter\u201d and \u201cDementia, Vascular\u201d, in combination with \u201cMigraine Disorders\u201d, \u201cMigraine with Aura\u201d and \u201cMigraine without Aura\u201d and reviewed the relevant studies. We studied articles mostly in English for the past 10 years, without excluding older articles that were relevant to this review. We also searched the reference lists of articles obtained and included some insightful reviews on 'Migraine and Vascular Risk'.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The association between migraine and vascular diseases is strong and consistent for ischemic stroke and migraine with aura especially in young women, with oral contraceptive use and smoking. Although literature reports a higher prevalence of obesity, dyslipidemia, and family history of cardiovascular diseases in migraineurs, the 'migraine-vascular' connection persists in models where the traditional vascular risk factors are adjusted, implicating a migraine-specific pathophysiology at work. There is some evidence linking an adverse vascular risk factor profile to incident myocardial infarction in people with migraine. The association with hemorrhagic stroke is more variable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although the absolute effect of migraine on 'vascular risks' is small, good practice parameters dwell on treating and reducing existing cardiovascular risk factors through lifestyle modification, encouraging smoking cessation, and advocating the wise use of agents like ergot alkaloids and oral contraceptives, after a risk-benefit analysis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0028-3886.315974","type":"journal-article","created":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T04:19:32Z","timestamp":1621138772000},"page":"S83-S90","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["Migraine and Vascular 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of cardiovascular and cerebrovascular events: A meta-analysis of 16 cohort studies including 1 152 407 subjects","volume":"8","author":"Mahmoud","year":"2018","journal-title":"BMJ Open"},{"key":"R7-11-20240907","doi-asserted-by":"crossref","first-page":"b3914","DOI":"10.1136\/bmj.b3914","article-title":"Migraine and cardiovascular disease: Systematic review and meta-analysis","volume":"339","author":"Sch\u00fcrks","year":"2009","journal-title":"BMJ"},{"key":"R8-11-20240907","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.amjmed.2009.12.021","article-title":"Migraine headache and ischemic stroke risk: An updated meta-analysis","volume":"123","author":"Spector","year":"2010","journal-title":"Am J Med"},{"key":"R9-11-20240907","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1001\/jama.296.3.283","article-title":"Migraine and risk of cardiovascular disease in 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