{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:22:40Z","timestamp":1787757760945,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Primary central nervous system lymphoma (PCNSL) is a rare disease that can be confused with Wernicke encephalopathy (WE). We have reported here the case of a 31-year-old malnourished man who presented with headache, fever, vomiting, diarrhea, and confusion. His imaging and laboratory findings were indicative of WE. His condition improved after treatment with a high dose of vitamin B1 and intravenous administration of methylprednisolone. However, after continuing to take vitamin B1 for 2 weeks, his symptoms and neuroimaging findings worsened. Increased standardized uptake values of positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro-D-glucose integrated with computed tomography (\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG-PET) and interleukin-10 (IL-10) in the cerebrospinal fluid led to the diagnosis of PCNSL. After treatment with methotrexate and calcium leucovorin, the symptoms and neuroimaging abnormalities disappeared at the 6-month follow-up examination. The possibility of PCNSL should be considered if the routine treatment for WE are ineffective.\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG PET and IL-10 may provide a new method for the early diagnosis of PCNSL.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0028-3886.319202","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T02:21:28Z","timestamp":1640658088000},"page":"740-743","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Primary Central Nervous System Lymphoma Mimicking Wernicke's Encephalopathy"],"prefix":"10.4103","volume":"69","author":[{"given":"Lei","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-42-20240907","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1097\/SMJ.0b013e318061920a","article-title":"Wernicke encephalopathy complicating lymphoma therapy: Case report and literature review","volume":"100","author":"Boniol","year":"2007","journal-title":"South Med J"},{"key":"R2-42-20240907","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/bjh.14073","article-title":"Trends in primary central nervous system lymphoma incidence and survival in the U.S","volume":"174","author":"Shiels","year":"2016","journal-title":"Br J Haematol"},{"key":"R3-42-20240907","doi-asserted-by":"crossref","first-page":"247152","DOI":"10.1155\/2013\/247152","article-title":"18F-FDG PET in the diagnosis and treatment of primary central nervous system lymphoma","volume":"2013","author":"Kawai","year":"2013","journal-title":"Biomed Res Int"},{"key":"R4-42-20240907","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s12149-011-0483-1","article-title":"Does adding FDG-PET to MRI improve the differentiation between primary cerebral lymphoma and glioblastoma? Observer performance study","volume":"25","author":"Makino","year":"2011","journal-title":"Ann Nucl Med"},{"key":"R5-42-20240907","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1001\/archopht.1997.01100160327010","article-title":"Association of interleukin 10 in the vitreous and cerebrospinal fluid and primary central nervous system lymphoma","volume":"115","author":"Whitcup","year":"1997","journal-title":"Arch Ophthalmol"},{"key":"R6-42-20240907","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/neuonc\/nor203","article-title":"Cerebrospinal fluid interleukin-10 is a potentially useful biomarker in immunocompetent primary central nervous system lymphoma (PCNSL)","volume":"14","author":"Sasayama","year":"2012","journal-title":"Neuro Oncol"},{"key":"R7-42-20240907","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1177\/1756285608101222","article-title":"Primary CNS lymphoma","volume":"2","author":"Schlegel","year":"2009","journal-title":"Ther Adv Neurol Disord"},{"key":"R8-42-20240907","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s12539-019-00333-y","article-title":"Quantitative and visual characteristics of primary central nervous system lymphoma on 18F-FDG-PET","volume":"11","author":"Liu","year":"2019","journal-title":"Interdiscip Sci"}],"container-title":["Neurology India"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.319202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:52:30Z","timestamp":1787755950000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.319202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/0028-3886.319202","relation":{},"ISSN":["0028-3886"],"issn-type":[{"value":"0028-3886","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]}}}