{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:22:25Z","timestamp":1787757745843,"version":"build-2784847793"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,11]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Pre-stroke anti-platelet (PAP) therapy can potentially influence the severity and outcome after ischemic stroke.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n We analyzed data from the prospective multicenter Indo\u2013US collaborative stroke project for the impact of PAP therapy. Outcome measures included the admission National Institute of Health Stroke Scale (NIHSS) score, 3-month modified Rankin scale (mRS) score, and rates of in-hospital mortality and post-ischemic intracerebral hemorrhage.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Among 2048 of 2066 patients (M:F = 2:1) with known pre-stroke medication status, 336 (16.3%) were on PAP therapy. As compared to the non-PAP group, the PAP group had significantly higher mean age (62.2 vs 57.4 years,\n P<\/jats:italic>\n < 0.001) and significantly more men, vascular risk factors, cerebral microbleeds (12.8% vs 6.2%,\n P<\/jats:italic>\n = 0.001) and intravenous thrombolysis treatment (17% vs. 10.6%,\n P<\/jats:italic>\n = 0.001). Cardioembolic strokes were significantly more in the PAP group (\n P<\/jats:italic>\n < 0.001), but not large artery atherosclerosis. No significant differences were observed in the median NIHSS score (9 vs. 10,\n P<\/jats:italic>\n = 0.274), 3-month mRS (score 0-2,51.4% vs. 49.0%,\n P<\/jats:italic>\n = 0.428), in-hospital mortality (8.6% vs. 7.8%,\n P<\/jats:italic>\n = 0.592), or symptomatic post ischemic intracerebral haemorrhage (12.2% vs. 10.6%,\n P<\/jats:italic>\n = 0.382). The PAP group had more stroke recurrence (6.6% vs. 2.9%,\n P<\/jats:italic>\n = 0.002) which was not significant (\n P<\/jats:italic>\n = 0.065) after multivariate regression analysis adjusting for age, sex and vascular risk factors. PAP therapy was not an independent predictor of initial stroke severity or stroke outcome.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n PAP therapy has no significant effect on initial stroke severity, rates of post-ischemic hemorrhage with or without thrombolysis, in-hospital mortality, stroke recurrence, and 3-month outcome after ischemic stroke.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/0028-3886.333484","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T01:47:50Z","timestamp":1640656070000},"page":"1645-1649","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Impact of Pre-Stroke Antiplatelet Use on 3-Month Outcome After Ischemic Stroke"],"prefix":"10.4103","volume":"69","author":[{"given":"PN","family":"Sylaja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sruthi 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