{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:59:38Z","timestamp":1787169578942,"version":"build-2736575974"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"\n Background and Purpose:<\/jats:title>\n Limited data is available regarding the prevalence of aortic plaques in cryptogenic ischemic strokes and its correlation with risk factors.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n To determine the prevalence of aortic plaques in patients with cryptogenic ischemic stroke and its association with vascular risk factors and future vascular events.<\/jats:p>\n <\/jats:sec>\n \n Methodology:<\/jats:title>\n Patients with cryptogenic ischemic stroke\/TIA evaluated with CT angiogram (CTA) were recruited. Aortic plaque thickness \u22654 mm, plaque ulceration, protruding components, and complex plaques were considered significant.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Of the 1,767 patients, 229 (12.9%) had cryptogenic ischemic stroke\/transient ischemic attack (TIA). Of them, 36 (15.7%) patients were detected to have significant aortic plaques. The significant plaque group had a higher mean age (68.3 \u00b1 8.3 vs 54.4 \u00b1 13.2,\n P<\/jats:italic>\n = 0.0005) and were more likely to have risk factors like hypertension (\n P<\/jats:italic>\n = 0.025), coronary artery disease (CAD)(\n P<\/jats:italic>\n = 0.015), and peripheral vascular disease (POVD) (\n P<\/jats:italic>\n = 0.029). Plaque morphology showed plaques of \u22654 mm, ulcerated plaques, protruding components, and complex plaques in 14.8%, 5.6%, 3.1%, and 6.5% patients, respectively, which are predominantly located in the aortic arch (44%). At 1 year combined endpoint of stroke, TIA, and vascular death was significantly higher in the significant plaque group (19.4% vs 6.2%,\n P<\/jats:italic>\n = 0.016). Advanced age (adjusted OR-1.11, 95% CI-1.07\u20131.17,\n P<\/jats:italic>\n = <0.001) was identified as an independent risk factor for significant aortic plaques on multivariate analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Aortic plaques are an under-recognized cause of cryptogenic stroke. The significant risk factors in aortic plaque group highlight the importance of aggressive risk factor control for secondary stroke prevention.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/0028-3886.336332","type":"journal-article","created":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T23:56:47Z","timestamp":1642982207000},"page":"182-187","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Prevalence of Aortic Plaques in Cryptogenic Ischemic Stroke"],"prefix":"10.4103","volume":"70","author":[{"given":"K","family":"Arun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poornima N","family":"Nambiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santhosh Kumar","family":"Kannath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sapna E","family":"Sreedharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajith","family":"Sukumaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sankara","family":"Sarma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P N","family":"Sylaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-38-20240907","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0002-8703(95)90243-0","article-title":"Ulcerated atherosclerotic plaques in the thoracic aorta are associated with cryptogenic stroke: A multiplane transesophageal echocardiographic study","volume":"130","author":"Stone","year":"1995","journal-title":"Am Heart J"},{"key":"R2-38-20240907","first-page":"218","article-title":"Proximal aortic atheroma. 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