{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:58:42Z","timestamp":1787169522775,"version":"build-2736575974"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Autonomic dysfunction can precede the onset of motor symptoms in Parkinson's disease and are very disabling, but often overlooked.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study was done to assess the presence of autonomic symptoms in PD; evaluate any gender differences and association of autonomic dysfunction with fatigue and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Demographic profile and disease characteristics of PD patients were assessed. Autonomic symptoms were evaluated by SCOPA-AUT, fatigue by FSS, and QOL with PDQ-39 in patient's vernacular language. Patients with SCOPA-AUT score \u22659 were considered as having autonomic impairment. Gender variation in the involvement of different domains were analyzed along with the risk factors for autonomic dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 94 patients, 59 (63%) had autonomic dysfunction. All SCOPA domains showed significant impairment in PD. Nocturia (69.14%) and constipation (52.12%) constituted most frequent symptoms in our cohort. Mean urinary (7.89 vs. 6.05) and sexual (1.47 vs. 0.42) domain scores were significantly (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05) higher in males while cardiovascular dysfunction (0.81 vs. 1.64) was predominant in females. Patients with autonomic dysfunction had longer duration of disease (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.033), severe disease (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0001) with higher UPDRS (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001). Autonomic symptoms correlated significantly (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001) with Fatigue (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.60) also. Patients with autonomic dysfunction had poor QOL (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.67) and mobility, activities of daily living, emotional well-being, stigma, cognition, communication, and bodily-discomfort dimensions were worst affected (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>There was a significant variation of autonomic symptoms with gender. Disease severity and duration were significant risk factors for autonomic dysfunction. Also there was a strong co-relation of fatigue and poor QOL with autonomic dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0028-3886.336334","type":"journal-article","created":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T23:56:47Z","timestamp":1642982207000},"page":"203-208","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Gender Differences and Impact of Autonomic Disturbance on Fatigue and Quality of Life in Parkinson's Disease"],"prefix":"10.4103","volume":"70","author":[{"given":"Nahush R","family":"Bansal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birinder S","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunchan","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gagandeep","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-41-20240907","doi-asserted-by":"crossref","first-page":"92","DOI":"10.14802\/jmd.15003","article-title":"Many Faces of Parkinson's disease: Non-motor symptoms of Parkinson's disease","volume":"8","author":"Lee","year":"2015","journal-title":"J Mov Disord"},{"key":"R2-41-20240907","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1212\/WNL.0b013e31827deb74","article-title":"The spectrum of nonmotor symptoms in early Parkinson disease","volume":"80","author":"Khoo","year":"2013","journal-title":"Neurology"},{"key":"R3-41-20240907","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nrn.2017.62","article-title":"Non-motor features of Parkinson disease [published correction appears in Nat Rev Neurosci 2017;18:509]","volume":"18","author":"Schapira","year":"2017","journal-title":"Nat Rev Neurosci"},{"key":"R4-41-20240907","first-page":"877","article-title":"Heart rate variability and the risk of Parkinson disease: The atherosclerosis risk in communities study Ann","volume":"77","author":"Alonso","year":"2015","journal-title":"Neurol"},{"key":"R5-41-20240907","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1212\/01.wnl.0000266593.50534.e8","article-title":"Patient-reported autonomic symptoms in Parkinson disease","volume":"69","author":"Verbaan","year":"2007","journal-title":"Neurology"},{"key":"R6-41-20240907","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s10286-015-0306-x","article-title":"In patient's with Parkinson disease, autonomic symptoms are frequent and associated with other non-motor symptoms","volume":"25","author":"Arnao","year":"2015","journal-title":"Clin Auton Res"},{"key":"R7-41-20240907","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s13760-016-0739-6","article-title":"Impact of autonomic dysfunctions on the quality of life in Parkinson's disease patients","volume":"117","author":"Tomic","year":"2017","journal-title":"Acta Neurol Belg"},{"key":"R8-41-20240907","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.parkreldis.2013.07.010","article-title":"Importance of motor vs non-motor symptoms for health-related quality of life in early Parkinson's disease","volume":"19","author":"Muller","year":"2013","journal-title":"Parkinsonism Relat Disord"},{"key":"R9-41-20240907","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jns.2017.04.023","article-title":"Association between autonomic dysfunction and fatigue in Parkinson's disease","volume":"377","author":"Chou","year":"2017","journal-title":"J Neurol Sci"},{"key":"R10-41-20240907","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1353-8020(99)00051-6","article-title":"Parkinson's disease subtypes: Clinical classification and ventricular cerebrospinal fluid analysis","volume":"6","author":"Schiess","year":"2000","journal-title":"Parkinsonism Relat Disord"},{"key":"R11-41-20240907","doi-asserted-by":"crossref","first-page":"451","DOI":"10.4103\/0972-2327.194419","article-title":"Assessment of fatigue in Parkinson's disease: Indian perspective","volume":"19","author":"Paul","year":"2016","journal-title":"Ann Indian Acad Neurol"},{"key":"R12-41-20240907","doi-asserted-by":"crossref","first-page":"346","DOI":"10.2298\/VSP1404346D","article-title":"When do the symptoms of autonomic nervous system malfunction appear in patients with Parkinson's disease","volume":"71","author":"De Luka","year":"2014","journal-title":"Vojnosanit Pregl"},{"key":"R13-41-20240907","doi-asserted-by":"crossref","first-page":"7","DOI":"10.14802\/jmd.14002","article-title":"The frequency and severity of gastrointestinal symptoms in patients with early Parkinson's disease","volume":"7","author":"Sung","year":"2015","journal-title":"J Mov Disord"},{"key":"R14-41-20240907","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/mds.26970","article-title":"Prevalence and burden of dysautonomia in advanced Parkinson's disease","volume":"32","author":"Merola","year":"2017","journal-title":"Mov Disord"},{"key":"R15-41-20240907","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1001\/jamaneurol.2017.1125","article-title":"Association of autonomic dysfunction with disease progression and survival in Parkinson's disease","volume":"74","author":"De Pablo-Fernandez","year":"2017","journal-title":"JAMA Neurology"},{"key":"R16-41-20240907","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S1474-4422(15)00007-1","article-title":"Gastrointestinal dysfunction in Parkinson's disease","volume":"14","author":"Fasano","year":"2015","journal-title":"Lancet Neurol"},{"key":"R17-41-20240907","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1540-8167.2008.01407.x","article-title":"Postural tachycardia syndrome (POTS)","volume":"20","author":"Low","year":"2009","journal-title":"J Cardiovasc Electrophysiol"},{"key":"R18-41-20240907","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1468-1331.2009.02788.x","article-title":"Independent validation of the scales for outcomes in Parkinson's diseases-autonomic (SCOPA-AUT)","volume":"17","author":"Rodriguez-Blazquez","year":"2010","journal-title":"Eur J Neurol"},{"key":"R19-41-20240907","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/mds.22882","article-title":"Psychometric properties of the SCOPA-AUT Brazilian Portuegese version","volume":"25","author":"Carod-Artal","year":"2010","journal-title":"Mov Disord"},{"key":"R20-41-20240907","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.4103\/0028-3886.226451","article-title":"Parkinson's disease: A review","volume":"66","author":"Radhakrishnan","year":"2018","journal-title":"Neurol India"},{"key":"R21-41-20240907","first-page":"115","article-title":"Self-reported autonomic symptoms in Parkinson's disease: Properties of the SCOPA-AUT scale","volume":"20","author":"Bostantjopoulou","year":"2016","journal-title":"Hippokratia"},{"key":"R22-41-20240907","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1002\/mds.26415","article-title":"New clinical trials for nonmotor manifestations of Parkinson's disease","volume":"30","author":"Schrag","year":"2015","journal-title":"Mov Disord"},{"key":"R24-41-20240907","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1212\/WNL.0000000000000587","article-title":"Prevalence of fatigue in Parkinson disease and its clinical correlates","volume":"83","author":"Stocchi","year":"2014","journal-title":"Neurology"}],"container-title":["Neurology India"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.336334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:07:55Z","timestamp":1787166475000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.336334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/0028-3886.336334","relation":{},"ISSN":["0028-3886"],"issn-type":[{"value":"0028-3886","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}