{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:18:46Z","timestamp":1787771926328,"version":"build-2784847793"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Wernekinck commissure syndrome is a rare midbrain infarction, it consists of several symptoms including bilateral cerebellar ataxia, ophthalmoplegia, and palatal tremor. Holmes tremor is a rare clinical syndrome characterized by a combination of resting, postural, and action tremors. We describe two cases of Wernekinck commissure syndrome with Holmes tremor. To the best of our knowledge, it has been rarely reported in the literature to date. Both of the cases were presented with acute onset of bilateral cerebellar ataxia, dysarthria, and Holmes tremor. In the treatment, one patient was given \u201cclonazepam and benheisol,\u201d the other was received acupuncture therapy, both of them showed a marked improvement in ataxia and tremor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0028-3886.338697","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:38:10Z","timestamp":1708475890000},"page":"281-284","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Wernekinck Commissure Syndrome with Holmes Tremor"],"prefix":"10.4103","volume":"70","author":[{"given":"Y T","family":"Ling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S G","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J T","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X Y","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L H","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-53-20240907","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.jocn.2009.11.032","article-title":"Wernekinck commissure syndrome is a pure midbrain infarction","volume":"17","author":"Zhu","year":"2010","journal-title":"J Clin Neurosci"},{"key":"R2-53-20240907","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s10072-012-0966-4","article-title":"Wernekink commissure syndrome: A rare midbrain syndrome","volume":"33","author":"Liu","year":"2012","journal-title":"Neurol Sci"},{"key":"R3-53-20240907","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1007\/s10072-014-1789-2","article-title":"Wernekink commissure syndrome secondary to ischemic stroke: Severe dysarthria is one of the main characteristics of this syndrome","volume":"35","author":"Kim","year":"2014","journal-title":"Neurol Sci"},{"key":"R4-53-20240907","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1007\/s10072-015-2285-z","article-title":"Botulinum toxin type A for Holmes tremor secondary to thalamic hemorrhage","volume":"36","author":"Latino","year":"2015","journal-title":"Neurol Sci"},{"key":"R5-53-20240907","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/mds.870131303","article-title":"Consensus statement of the movement disorder society on tremor. Ad Hoc scientific committee","volume":"13","author":"Deuschl","year":"1998","journal-title":"Mov Disord"},{"key":"R6-53-20240907","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s13256-018-1657-4","article-title":"Wernekink commissure syndrome with palatal myoclonus at onset: A case report and review of the literature","volume":"12","author":"Mullaguri","year":"2018","journal-title":"J Med Case Rep"},{"key":"R7-53-20240907","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12311-013-0520-9","article-title":"The Horseshoe-Shaped commissure of Wernekinck or the decussation of the brachium conjunctivum methodological changes in the 1840s","volume":"13","author":"Voogd","year":"2013","journal-title":"The Cerebellum"},{"key":"R8-53-20240907","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1212\/01.WNL.0000156520.46056.6B","article-title":"Pure midbrain infarction: Clinical, radiologic, and pathophysiologic findings","volume":"64","author":"Kim","year":"2005","journal-title":"Neurology"},{"key":"R9-53-20240907","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s00415-016-8088-1","article-title":"Internuclear ophthalmoplegia plus ataxia indicates a dorsomedial tegmental lesion at the pontomesencephalic junction","volume":"263","author":"Lee","year":"2016","journal-title":"J Neurol"},{"key":"R10-53-20240907","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1212\/01.wnl.0000218180.03127.11","article-title":"Caudal paramedian midbrain syndrome","volume":"66","author":"Mossuto-Agatiello","year":"2006","journal-title":"Neurology"},{"key":"R11-53-20240907","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1002\/mds.10141","article-title":"Pathophysiology of nonparkinsonian tremors","volume":"17","author":"Deuschl","year":"2002","journal-title":"Mov Disord"},{"key":"R12-53-20240907","first-page":"558","article-title":"Treatment responsive Holmes tremor: Case report and literature review","volume":"10","author":"Alqwaifly","year":"2016","journal-title":"Int J Health Sci (Qassim"},{"key":"R13-53-20240907","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.4103\/0028-3886.190299","article-title":"Wernekink commissure syndrome","volume":"64","author":"Sheetal","year":"2016","journal-title":"Neurol India"},{"key":"R14-53-20240907","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3389\/fneur.2017.00376","article-title":"Wernekink commissure syndrome secondary to bilateral caudal paramedian midbrain infarction presenting with a unique \u201cHeart or V\u201d appearance sign: Case report and review of the literature","volume":"8","author":"Zhou","year":"2017","journal-title":"Front Neurol"},{"key":"R16-53-20240907","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1002\/mds.22230","article-title":"Successful treatment of Holmes tremor by levetiracetam","volume":"23","author":"Ferlazzo","year":"2008","journal-title":"Mov Disord"},{"key":"R17-53-20240907","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1212\/WNL.0000000000002440","article-title":"Holmes tremor: Clinical description, lesion localization, and treatment in a series of 29 cases","volume":"86","author":"Raina","year":"2016","journal-title":"Neurology"},{"key":"R18-53-20240907","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fsurg.2018.00021","article-title":"Successful treatment of holmes tremor with deep brain stimulation of the prelemniscal radiations","volume":"5","author":"Martinez","year":"2018","journal-title":"Front Surg"},{"key":"R19-53-20240907","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jocn.2018.10.041","article-title":"Deep brain stimulation of the ventralis intermedius nucleus of the thalamus and posterior subthalamic area for Holmes' tremor secondary to brainstem hemorrhage: A case report","volume":"60","author":"Yuk","year":"2019","journal-title":"J Clin Neurosci"},{"key":"R20-53-20240907","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3389\/fnagi.2018.00206","article-title":"Acupuncture modulates the Cerebello-Thalamo-Cortical circuit and cognitive brain regions in patients of Parkinson's disease with tremor","volume":"10","author":"Li","year":"2018","journal-title":"Front Aging Neurosci"}],"container-title":["Neurology India"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.338697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:20:45Z","timestamp":1787768445000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.338697"}},"subtitle":["A Report of Two Cases and Review of Literature"],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/0028-3886.338697","relation":{},"ISSN":["0028-3886"],"issn-type":[{"value":"0028-3886","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}