{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:43:23Z","timestamp":1791315803641,"version":"4.3.1"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"\n Background:<\/jats:title>\n Subacute sclerosing panencephalitis (SSPE) is a rare entity characterized by a protracted course and progressive neurological deterioration.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n We present patterns of diffusion restriction in eight cases of SSPE, a seldom described imaging attribute.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A retrospective analysis was performed on the clinical and neuroimaging data obtained from records of patients with proven SSPE. Patients whose magnetic resonance imaging (MRI) showed evidence of diffusion restriction were included in the analysis. MRI was performed on 3 T and 1.5-T clinical MR systems. Imaging characteristics were reviewed and tabulated by two neuroradiologists.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Eight SSPE patients (seven men, one woman; age range: 5\u201315 years; mean age: 11 years) diagnosed and managed at our institute were included in the analysis. Restricted diffusion was evident in the basal ganglia (\n n =<\/jats:italic>\n 3), corpus callosum (\n n =<\/jats:italic>\n 2), white matter (\n n =<\/jats:italic>\n 2) and in bilateral middle cerebellar peduncles (MCP) (\n n =<\/jats:italic>\n 2). One patient had diffusion restriction in the genu of the corpus callosum and bilateral frontal cortical white matter. None of the diffusion-restricted lesions showed contrast enhancement or susceptibility. Six cases fulfilled the diagnostic criteria for fulminant SSPE (fSSPE). The extent of neuroparenchymal involvement was greater in this subset of patients.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Restricted diffusion in SSPE, hitherto infrequently described, can indeed occur in both grey and white matter structures and in both supratentorial and infratentorial compartments. Parenchymal diffusion restriction in SSPE possibly reflects an early time point in the clinical evolution. A greater extent of parenchymal diffusion restriction may portend a rapid downhill course, possibly qualifying for fSSPE.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/0028-3886.338737","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:38:10Z","timestamp":1708475890000},"page":"275-280","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Subacute Sclerosing Panencephalitis"],"prefix":"10.4103","volume":"70","author":[{"given":"Chandrajit","family":"Prasad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Netravathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthik","family":"Kulanthaivelu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya D","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hima","family":"Pendharkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-52-20240907","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1111\/j.1469-8749.2010.03717.x","article-title":"Subacute sclerosing panencephalitis: An update: Review","volume":"52","author":"Gutierrez","year":"2010","journal-title":"Dev Med Child Neurol"},{"key":"R2-52-20240907","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1177\/000992289703600306","article-title":"Fulminating subacute scierosing panencephalitis: Case report and literature review","volume":"36","author":"PeBenito","year":"1997","journal-title":"Clin Pediatr (Phila"},{"key":"R3-52-20240907","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.braindev.2006.09.013","article-title":"MR imaging, diffusion-weighted imaging and MR spectroscopy findings in acute rapidly progressive subacute sclerosing panencephalitis","volume":"29","author":"Oguz","year":"2007","journal-title":"Brain Devel"},{"key":"R4-52-20240907","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.4103\/0028-3886.217942","article-title":"An unusual case of acute encephalitic syndrome: Is it acute measles encephalitis or subacute sclerosing panencephalitis?","volume":"65","author":"Garg","year":"2017","journal-title":"Neurol India"},{"key":"R5-52-20240907","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1007\/s002340050323","article-title":"MRI in subacute sclerosing panencephalitis","volume":"38","author":"Tuncay","year":"1996","journal-title":"Neuroradiology"},{"key":"R7-52-20240907","doi-asserted-by":"crossref","first-page":"452","DOI":"10.4103\/0028-3886.158268","article-title":"Diffusion restriction in fulminant subacute sclerosing panencephalitis: Report of an unusual finding","volume":"63","author":"Shah","year":"2015","journal-title":"Neurol India"},{"key":"R8-52-20240907","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/01.rct.0000185276.91838.de","article-title":"Early detection of subacute sclerosing panencephalitis by high b-value diffusion-weighted imaging: A case report","volume":"30","author":"Tha","year":"2006","journal-title":"J Comput Assist Tomogr"},{"key":"R9-52-20240907","first-page":"237","article-title":"Quantitative evaluation of intranuclear inclusions in SSPE: Correlation with disease duration","volume":"39","author":"Lewandowska","year":"2001","journal-title":"Folia Neuropathol"},{"key":"R10-52-20240907","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1440-1789.2008.00891.x","article-title":"Case of fulminant-SSPE associated with measles genotype D7 from India: An autopsy study","volume":"28","author":"Mahadevan","year":"2008","journal-title":"Neuropathology"},{"key":"R11-52-20240907","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1177\/08830738020170101101","article-title":"Neurodegenerative mechanisms in subacute sclerosing panencephalitis","volume":"17","author":"Hayashi","year":"2002","journal-title":"J Child Neurol"},{"key":"R12-52-20240907","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.pediatrneurol.2008.01.014","article-title":"Serial diffusion-weighted imaging in subacute sclerosing panencephalitis","volume":"38","author":"Kanemura","year":"2008","journal-title":"Pediatr Neurol"},{"key":"R13-52-20240907","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/jmri.20518","article-title":"Subacute sclerosing panencephalitis: Relationship between clinical stage and diffusion-weighted imaging findings","volume":"23","author":"Alkan","year":"2006","journal-title":"J Magn Reson Imaging"}],"container-title":["Neurology India"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.338737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:21:00Z","timestamp":1787768460000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.338737"}},"subtitle":["Restricted Diffusion and Clinical Evolution"],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/0028-3886.338737","relation":{},"ISSN":["0028-3886"],"issn-type":[{"value":"0028-3886","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}