{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:30:50Z","timestamp":1786728650891,"version":"build-2736575974"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The literature regarding the utility of cerebrospinal fluid (CSF) procalcitonin (PCT) in the diagnosis of post-craniotomy bacterial meningitis and differentiating it from aseptic meningitis is sparse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      CSF total WBC count, sugar, protein, and PCT were measured in febrile patients with suspected post-craniotomy meningitis during the first 30 days following an intradural cranial procedure for non-trauma indications. Patients were diagnosed as postoperative bacterial meningitis if CSF culture was positive (PBM,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 28) or postoperative aseptic meningitis if CSF culture was sterile and there was no evidence of systemic infection (PAM,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 31). CSF cytochemical parameters and PCT values were compared between the groups. Normal values of CSF PCT were obtained from 14 patients with noninfectious indications with hydrocephalus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There was no significant difference in CSF total WBC count, sugar, and protein levels between PAM and PBM groups. The median PCT level in CSF in the normal group was 0.03 ng\/mL (interquartile range [IQR] 0.02\u20130.07 ng\/mL). CSF PCT in the PBM group (median 0.37 ng\/mL, IQR 0.2\u20131.4 ng\/mL) was significantly higher than normal values as well as PAM group (median 0.12 ng\/mL, IQR 0.07\u20130.26 ng\/mL (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0004). The area under the receiver operating characteristic (ROC) curve for CSF PCT was 0.767. A cutoff value of 0.12 ng\/mL yielded a sensitivity of 85.7% (95% CI: 67.3% to 96%), specificity of 51.6% (95% CI: 33% to 69.9%), positive predictive value of 61.5% (95% CI: 51.9% to 70.3%), and negative predictive value of 80% (95% CI: 60.3.8% to 91.3%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>CSF PCT assay in patients who are febrile during the first 30 days post-non-trauma neurosurgical procedures has a role in the early diagnosis of bacterial meningitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0028-3886.344643","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T04:05:56Z","timestamp":1692849956000},"page":"721-726","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Cerebrospinal Fluid Procalcitonin\u2014A Potential Biomarker for Post-Craniotomy Bacterial Meningitis"],"prefix":"10.4103","volume":"70","author":[{"given":"Ranjith K","family":"Moorthy","sequence":"first","affiliation":[{"name":"Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Job","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Rebekah","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedantam","family":"Rajshekhar","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,5,3]]},"reference":[{"key":"R1-20260803","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jocn.2017.09.021","article-title":"Complications and 30-day readmission rates after craniotomy\/craniectomy: A single institutional study of 243 consecutive patients","volume":"47","author":"Elsamadicy","year":"2018","journal-title":"J Clin Neurosci"},{"key":"R2-20260803","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1159\/000339312","article-title":"Perioperative factors associated with prolonged intensive care unit and hospital length of stay after pediatric neurosurgery","volume":"47","author":"Mekitarian Filho","year":"2011","journal-title":"Pediatr Neurosurg"},{"key":"R3-20260803","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3109\/02688697.2013.771138","article-title":"Conservative antibiotic policy in patients undergoing non-trauma cranial surgery does not result in higher rates of postoperative meningitis: An audit of nine years of narrow-spectrum prophylaxis","volume":"27","author":"Moorthy","year":"2013","journal-title":"Br J Neurosurg"},{"key":"R4-20260803","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1086\/518169","article-title":"Evaluation of the management of postoperative aseptic meningitis","volume":"15","author":"Zarrouk","year":"2007","journal-title":"Clin Infect Dis"},{"key":"R5-20260803","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3171\/jns.1988.69.5.0669","article-title":"Differentiation of aseptic and bacterial meningitis in postoperative neurosurgical patients","volume":"69","author":"Ross","year":"1998","journal-title":"J Neurosurg"},{"key":"R6-20260803","doi-asserted-by":"crossref","first-page":"722","DOI":"10.4103\/0028-3886.232330","article-title":"Prognostic value of cerebrospinal fluid lactate in meningitis in postoperative neurosurgical patients","volume":"66","author":"Sumanth Kumar","year":"2018","journal-title":"Neurol India"},{"key":"R7-20260803","first-page":"68","article-title":"The role of serum procalcitonin in the diagnosis of bacterial meningitis in adults: A systematic review and meta-analysis. 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