{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:27:20Z","timestamp":1786728440446,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Schizencephaly is a rare congenital disorder of cerebral cortical development. Clinical features vary based on the areas and severity of cortical involvement. The most prominent manifestations being motor deficits, seizures, and cognitive impairment. MRI has been the diagnostic modality of choice. Till now, a handful of case reports associating schizencephaly with psychiatric manifestations have been reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this brief report, we review the available literature and present the summary of a 50-year-old gentleman who presented with paranoia, irritability, impulsive spending, emotional lability, and circumstantial speech with perseveration of themes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>MRI findings are suggestive of closed lip schizencephaly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This case helps us in understanding the neurodevelopmental model and functional neuroanatomy of psychiatric symptom dimensions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0028-3886.344662","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T04:05:56Z","timestamp":1692849956000},"page":"740-743","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Schizencephaly and the Neurodevelopmental Model of Psychosis"],"prefix":"10.4103","volume":"70","author":[{"given":"Rahul","family":"Patwal","sequence":"first","affiliation":[{"name":"Departmen of Psychiatry, National Institute of Mental Health and Neuro Sciences, Hosur Road, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen Manohar","family":"Pai","sequence":"additional","affiliation":[{"name":"Departmen of Psychiatry, National Institute of Mental Health and Neuro Sciences, Hosur Road, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundarnag","family":"Ganjekar","sequence":"additional","affiliation":[{"name":"Departmen of Psychiatry, National Institute of Mental Health and Neuro Sciences, Hosur Road, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faheem","family":"Arshad","sequence":"additional","affiliation":[{"name":"Departmen of Neurology, National Institute of Mental Health and Neuro Sciences, Hosur Road, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvarna","family":"Alladi","sequence":"additional","affiliation":[{"name":"Departmen of Neurology, National Institute of Mental Health and Neuro Sciences, Hosur Road, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj Kumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"Departmen of Clinical Psychology, National Institute of Mental Health and Neuro Sciences, Hosur Road, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetha","family":"Desai","sequence":"additional","affiliation":[{"name":"Departmen of Psychiatry, National Institute of Mental Health and Neuro Sciences, Hosur Road, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh K","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"Departmen of Psychiatry, National Institute of Mental Health and Neuro Sciences, Hosur Road, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,5,3]]},"reference":[{"key":"R1-20260803","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/uog.9069","article-title":"Schizencephaly prevalence, prenatal diagnosis and clues to etiology: A register-based study","volume":"39","author":"Howe","year":"2012","journal-title":"Ultrasound Obstet Gynecol"},{"key":"R2-20260803","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00381-015-2638-1","article-title":"Schizencephaly-diagnostics and clinical dilemmas","volume":"31","author":"Halabuda","year":"2015","journal-title":"Childs Nerv Syst"},{"key":"R3-20260803","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/1550059418781119","article-title":"Latent schizencephaly with psychotic phenotype or schizophrenia with schizencephaly? A case report and review of the literature","volume":"50","author":"Tyl\u0161","year":"2019","journal-title":"Clin EEG Neurosci"},{"key":"R4-20260803","doi-asserted-by":"crossref","first-page":"210868","DOI":"10.1155\/2013\/210868","article-title":"Schizencephaly and psychosis: A rare association","volume":"2013","author":"Melo","year":"2013","journal-title":"Case Rep Med"},{"key":"R5-20260803","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1136\/jnnp.63.3.373","article-title":"Schizencephaly associated with psychosis","volume":"63","author":"Alexander","year":"1997","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R6-20260803","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3109\/10401239409148839","article-title":"Severe imipramine-induced myoclonus in a patient with psychotic bipolar depression, catatonia, and schizencephaly","volume":"6","author":"Black","year":"1994","journal-title":"Ann Clin Psychiatry"},{"key":"R7-20260803","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ajp.2015.06.010","article-title":"Schizencephaly associated psychosis","volume":"16","author":"Tibrewal","year":"2015","journal-title":"Asian J Psychiatry"},{"key":"R8-20260803","first-page":"194","article-title":"Schizencephaly associated with bipolar affective disorder","volume":"50","author":"Relan","year":"2002","journal-title":"Neurol India"},{"key":"R9-20260803","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4103\/2141-9248.129065","article-title":"Unilateral closed lip schizencephaly with septo-optic dysplasia","volume":"4","author":"Bhatnagar","journal-title":"Ann Med Health Sci Res"},{"key":"R10-20260803","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1192\/bjp.bp.110.084384","article-title":"Neurodevelopmental hypothesis of schizophrenia","volume":"198","author":"Owen","year":"2011","journal-title":"Br J Psychiatry"},{"key":"R11-20260803","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.neubiorev.2009.09.004","article-title":"The functional neuroanatomy of symptom dimensions in schizophrenia: A qualitative and quantitative review of a persistent question","volume":"34","author":"Goghari","year":"2010","journal-title":"Neurosci Biobehav Rev"},{"key":"R12-20260803","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11065-005-6254-9","article-title":"A meta-analysis of cognitive deficits in adults with a diagnosis of schizophrenia","volume":"15","author":"Fioravanti","year":"2005","journal-title":"Neuropsychol Rev"}],"container-title":["Neurology India"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.344662","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:27:03Z","timestamp":1786724823000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.344662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/0028-3886.344662","relation":{},"ISSN":["0028-3886","1998-4022"],"issn-type":[{"value":"0028-3886","type":"print"},{"value":"1998-4022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"2020-05-24","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-14","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}