{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:17:17Z","timestamp":1787840237654,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Management strategies for petroclival menigiomas remain controversial<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We share our experience in management of large and giant true petroclival meniongiomas with special emphasis on patient reported quality of life parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This is a single center study of 47 patients between 2008 and 2018. All patients were checked for tumor specific parameters, clinical parameters, extent of surgical excision, and outcome, as assessed by Karnofsky performance score (KPS), Glasgow outcome score, clinical status, and by SF-36 questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      32\/47 patients' data were assessed. Symptoms included headache (62.5%), involvement of 5\n                      <jats:sup>th<\/jats:sup>\n                      nerve (47%), facial nerve (40.6%), lower cranial nerves (37.5%), cerebellar signs (84%), and long tract signs in (50%) of patients. The mean preoperative KPS was 83.75+\/\u22126.59. Surgical approaches included retromastoid suboccipital craniotomy (50%), Kawase's approach (31.25%), and others in 18.25% patients. 40.625% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 13) had a gross total excision, near total resection (NTR) was achieved in 53.125% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 17), and 6.25% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 2) had a subtotal excision (STE). In 13 patients who had gross total resection (GTR), there were 12 (70.5%) new neurological deficits, while among the 19 patients with NTR, only 5 (29.5%) new neurological deficits were seen. No new onset neurological deficit was seen in patients with STE of tumor. Patient assessed QoL parameters were worse in patients with GTR and best in patients with NTR\/STE + GKRS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In patients of large\/giant petroclival meningiomas, NTE\/STE with adjuvant GKRS provided better preservation of quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0028-3886.349614","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T03:55:57Z","timestamp":1692849357000},"page":"897-904","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Surgical Outcome Analysis of Large and Giant Petroclival Meningiomas with Special Reference to Quality of Life Issues"],"prefix":"10.4103","volume":"70","author":[{"given":"Aman","family":"Batish","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil K","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju","family":"Mohanty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjul","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravin","family":"Salunke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20241013","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3171\/jns.1996.84.1.0020","article-title":"Petroclival meningiomas: Surgical experience in 109 cases","volume":"84","author":"Couldwell","year":"1996","journal-title":"J Neurosurg"},{"key":"R2-12-20241013","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.surneu.2003.12.008","article-title":"Conventional posterior fossa approach for surgery on petroclival meningiomas: A report on an experience with 28 cases","volume":"62","author":"Goel","year":"2004","journal-title":"Surg Neurol"},{"key":"R3-12-20241013","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1227\/01.NEU.0000255472.52882.D6","article-title":"Petroclival meningiomas: Multimodality treatment and outcomes at long-term follow-up","volume":"60","author":"Natarajan","year":"2007","journal-title":"Neurosurgery"},{"key":"R4-12-20241013","first-page":"202","article-title":"Evolution of surgical approaches in the treatment of petroclival meningiomas: A retrospective review","volume":"61","author":"Bambakidis","year":"2007","journal-title":"Neurosurgery"},{"key":"R5-12-20241013","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1227\/01.NEU.0000333784.04435.65","article-title":"Evolution of surgical approaches in the treatment of petroclival meningiomas: A retrospective review","volume":"62","author":"Bambakidis","year":"2008","journal-title":"Neurosurgery"},{"key":"R6-12-20241013","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s00701-010-0633-6","article-title":"Clinical management of petroclival meningiomas and the eternal quest for preservation of quality of life: Personal experiences over a period of 20 years","volume":"152","author":"Seifert","year":"2010","journal-title":"Acta Neurochir (Wien"},{"key":"R7-12-20241013","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.3171\/2010.11.JNS10326","article-title":"Petroclival meningiomas: Study on outcomes, complications and recurrence rates","volume":"114","author":"Nanda","year":"2011","journal-title":"J Neurosurg"},{"key":"R8-12-20241013","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3171\/2011.2.JNS101759","article-title":"Lateral supracerebellar transtentorial approach for petroclival meningiomas: Operative technique and outcome","volume":"115","author":"Watanabe","year":"2011","journal-title":"J Neurosurg"},{"key":"R9-12-20241013","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1055\/s-0032-1304557","article-title":"Subtemporal transtentorial petrosalapex approach for giant petroclival meningiomas: Analyzation and evaluation of the clinical application","volume":"73","author":"Yang","year":"2012","journal-title":"J Neurol Surg B Skull Base"},{"key":"R10-12-20241013","doi-asserted-by":"crossref","first-page":"E11","DOI":"10.3171\/2013.9.FOCUS13319","article-title":"Petroclival meningiomas: An update on surgical approaches, decision making, and treatment results","volume":"35","author":"Xu","year":"2013","journal-title":"Neurosurg Focus"},{"key":"R11-12-20241013","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1007\/s00701-013-1795-9","article-title":"Surgical management and outcomes of petroclival meningiomas: A single-center case series of 259 patients","volume":"155","author":"Li","year":"2013","journal-title":"Acta Neurochir (Wien"},{"key":"R12-12-20241013","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3171\/2013.8.JNS13535","article-title":"True petroclival meningiomas: Results of surgical management","volume":"120","author":"Almefty","year":"2014","journal-title":"J Neurosurg"},{"key":"R13-12-20241013","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3171\/2014.8.JNS132406","article-title":"Petroclival meningiomas resected via a combined transpetrosal approach: Surgical outcomes in 60 cases and a new scoring system for clinical evaluation","volume":"122","author":"Morisako","year":"2015","journal-title":"J Neurosurg"},{"key":"R14-12-20241013","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.wneu.2015.10.014","article-title":"Which strategy for petroclival tumors?","volume":"86","author":"de Divitiis","year":"2016","journal-title":"World Neurosurg"},{"key":"R15-12-20241013","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.wneu.2016.06.018","article-title":"The analysis of the petrosal vein to prevent venous complications during the anterior transpetrosal approach in the resection of petroclival meningioma","volume":"93","author":"Mizutani","year":"2016","journal-title":"World Neurosurg"},{"key":"R16-12-20241013","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.wneu.2016.12.001","article-title":"Outcomes of endonasal and lateral approaches to petroclival meningiomas","volume":"99","author":"Koutourousiou","year":"2017","journal-title":"World Neurosurg"},{"key":"R17-12-20241013","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.4103\/0028-3886.241354","article-title":"Surgical excision of large-to-giant petroclival meningiomas focusing on the middle fossa approaches: The lessons learnt","volume":"66","author":"Gosal","year":"2018","journal-title":"Neurol India"},{"key":"R18-12-20241013","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.4103\/0028-3886.241376","article-title":"Surgical taming of petroclival meningiomas: King Cobra of all skull base tumors","volume":"66","author":"Abraham","year":"2018","journal-title":"Neurol India"},{"key":"R19-12-20241013","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/ons\/opx098","article-title":"Tumor progression following petroclival meningioma subtotal resection: A volumetric study","volume":"14","author":"Hunter","year":"2018","journal-title":"Oper Neurosurg (Hagerstown"},{"key":"R20-12-20241013","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1055\/s-0037-1608654","article-title":"Petroclival meningiomas: Factors determining the choice of approach","volume":"79","author":"Isolan","year":"2018","journal-title":"J Neurol Surg B Skull Base"},{"key":"R21-12-20241013","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.3171\/2012.9.JNS12429","article-title":"Intradural anterior petrosectomy for petroclival meningiomas: A new surgical technique and results in 5 patients: Technical note","volume":"117","author":"Gupta","year":"2012","journal-title":"J Neurosurg"},{"key":"R22-12-20241013","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1007\/s00701-017-3332-8","article-title":"Health-related quality of life of cranial WHO grade I meningioma patients: Are current questionnaires relevant?","volume":"159","author":"Zamanipoor Najafabadi","year":"2017","journal-title":"Acta Neurochir (Wien"},{"key":"R23-12-20241013","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.clineuro.2018.01.016","article-title":"Factors of influence upon the SF-36-based health related quality of life of patients following surgery for petroclival and lateral posterior surface of pyramid meningiomas","volume":"166","author":"Pintea","year":"2018","journal-title":"Clin Neurol Neurosurg"},{"key":"R24-12-20241013","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1055\/s-0029-1242978","article-title":"Instruments for estimation of health-related quality of life in patients with skull base neoplasms","volume":"20","author":"Witgert","year":"2010","journal-title":"Skull Base"},{"key":"R25-12-20241013","first-page":"897","article-title":"Impaired health-related quality of life in meningioma patients-A systematic review","volume":"19","author":"Zamanipoor Najafabadi","year":"2017","journal-title":"Neuro Oncol"},{"key":"R26-12-20241013","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3171\/2009.4.SPINE08749","article-title":"Quality of life assessment after central corpectomy for cervical spondylotic myelopathy: Comparative evaluation of the 36-Item Short Form Health Survey and the World Health Organization Quality of Life-Bref","volume":"11","author":"Thakar","year":"2009","journal-title":"J Neurosurg Spine"}],"container-title":["Neurology India"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.349614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:18:06Z","timestamp":1787836686000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.349614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/0028-3886.349614","relation":{},"ISSN":["0028-3886"],"issn-type":[{"value":"0028-3886","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]}}}