{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:17:22Z","timestamp":1787840242565,"version":"build-2784847793"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Myopathies associated with systemic diseases results from several different disease processes. Myopathy as the initial presenting symptom in Crohn's disease is a rare presentation. We report a 20-yearr-old lady who presented with a painful proximal myopathy. On examination, she was malnourished with pallor, angular cheilitis, Bitots spots, and bilateral pitting pedal edema. Laboratory evaluation showed iron deficiency anemia, hypoalbuminemia, and very low vitamin D levels with elevated creatine phosphokinase levels. A possibility of osteomalacic metabolic myopathy due to vitamin D deficiency was considered. The malabsorption workup was negative. A colonoscopic biopsy showed noncaseating granulomatous inflammation suggestive of Crohn's disease. With supplementary therapy and specific treatment, she was asymptomatic at 6-months follow-up with no residual neurological deficits. A detailed history and an algorithmic approach will be very useful in making the differential diagnosis in any patient presenting with muscle weakness in myopathy associated with systemic illness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0028-3886.349639","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T03:55:57Z","timestamp":1692849357000},"page":"1235-1237","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Crohn's Disease Presenting as Metabolic Myopathy"],"prefix":"10.4103","volume":"70","author":[{"given":"Sabu Kunnathuparambil","family":"George","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neena","family":"Baby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanth","family":"Varghese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalakottur Kuriakose","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-72-20241013","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3389\/fneur.2011.00049","article-title":"Stepwise approach to myopathy in systemic disease","volume":"2","author":"Chawla","year":"2011","journal-title":"Front Neur"},{"key":"R2-72-20241013","doi-asserted-by":"crossref","first-page":"15787","DOI":"10.3748\/wjg.v20.i42.15787","article-title":"Higher vitamin D serum concentration increases health related quality of life in patients with inflammatory bowel diseases","volume":"20","author":"Hlavaty","year":"2014","journal-title":"World J Gastroenterol"},{"key":"R3-72-20241013","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1002\/ibd.20942","article-title":"Musculoskeletal manifestations of inflammatory bowel disease","volume":"15","author":"Bourikas","year":"2009","journal-title":"Inflamm Bowel Dis"},{"key":"R4-72-20241013","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1017\/S0317167100007083","article-title":"Severe proximal myopathy with remarkable recovery after vitamin D treatment","volume":"36","author":"Al-Said","year":"2009","journal-title":"Can J Neurol Sci"},{"key":"R5-72-20241013","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.nut.2015.11.008","article-title":"Vitamin D status in relation to Crohn's disease: Meta-analysis of observational studies","volume":"32","author":"Sadeghian","year":"2016","journal-title":"Nutrition"}],"container-title":["Neurology India"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.349639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:18:08Z","timestamp":1787836688000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.349639"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/0028-3886.349639","relation":{},"ISSN":["0028-3886"],"issn-type":[{"value":"0028-3886","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]}}}