{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:17:33Z","timestamp":1787840253668,"version":"build-2784847793"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Histiocytic sarcoma (HS) is an aggressive hematolymphoid malignancy that arises from non Langerhans histiocytes and usually involves the skin, lymph nodes, and intestine. The involvement of the central nervous system (CNS) is a rare occurrence with around 30 cases being reported in English literature. Morphological and immunohistochemical evidence of histiocytic differentiation is essential for diagnosis. Prognosis is very poor and consensus on treatment is not available mainly due to its rarity. We report two cases of HS with varied clinical presentation and pathological findings and elucidate the diagnostic challenges of this rare entity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0028-3886.349657","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T03:55:57Z","timestamp":1692849357000},"page":"1254-1259","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Primary Histiocytic Sarcoma of Brain\u2014Illustration of Two Cases with Varied Histomorphological Features"],"prefix":"10.4103","volume":"70","author":[{"given":"Madhu","family":"Rajeshwari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaishali","family":"Suri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitra","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehar Chand","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-78-20241013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2559.2002.01418.x","article-title":"Tumours of histiocytes and accessory dendritic cells: An immunohistochemical approach to classification from the International lymphoma study group based on 61 cases","volume":"41","author":"Pileri","year":"2002","journal-title":"Histopathology"},{"key":"R2-78-20241013","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/neup.12390","article-title":"Primary histiocytic sarcoma presenting as diffuse leptomeningeal disease: Case description and review of the literature","volume":"37","author":"Zanelli","year":"2017","journal-title":"Neuropathology"},{"key":"R3-78-20241013","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/nan.12490","article-title":"Molecular characteristics of multifocal brain histiocytic sarcoma","volume":"45","author":"Marguet","year":"2019","journal-title":"Neuropathol Appl Neurobiol"},{"key":"R4-78-20241013","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/00000478-200302000-00017","article-title":"Histiocytic sarcoma involving the centralnervous system: Clinical, immunohistochemical, and molecular genetic studies of acase with review of the literature","volume":"27","author":"Sun","year":"2003","journal-title":"Am J SurgPathol"},{"key":"R5-78-20241013","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.wneu.2010.07.002","article-title":"Primary intramedullaryhistiocytic sarcoma","volume":"74","author":"Toshkezi","year":"2010","journal-title":"World Neurosurg"},{"key":"R6-78-20241013","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1365-2990.2011.01205.x","article-title":"Primary meningeal histiocytic sarcoma: Areport of two unusual cases","volume":"38","author":"Bell","year":"2012","journal-title":"Neuropathol Appl Neurobiol"},{"key":"R7-78-20241013","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3171\/2012.5.PEDS11270","article-title":"Primary cerebellar histiocytic sarcoma in a 17-month-old girl","volume":"10","author":"Gomi","year":"2012","journal-title":"J Neurosurg Pediatr"},{"key":"R8-78-20241013","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s10014-014-0191-3","article-title":"Histiocytic sarcoma of the cavernous sinus: Case report and literature review","volume":"32","author":"Chen","year":"2015","journal-title":"Brain Tumor Pathol"},{"key":"R10-78-20241013","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1182\/blood-2016-01-690636","article-title":"Histiocyte society. 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