{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:29:16Z","timestamp":1791041356872,"version":"4.1.0"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Calcific miliary brain metastasis is an extremely rare form of brain secondaries. A 52-year-old man diagnosed with lung adenocarcinoma, on oncotherapy with gefitinib had a partial initial response to treatment. Later he was readmitted with seizures and cognitive dysfunction. His initial brain computed tomography (CT) and magnetic resonance imaging (MRI) were normal. However, his later CT images revealed multiple small calcified lesions over both hemispheres and contrast MRI revealed scattered tiny miliary nodules enhanced by gadolinium over bilateral cerebral, cerebellar hemispheres, thalami, and basal ganglia with foci of hypointensity in susceptibility-weighted images (SWI) and phase imaging suggesting calcification. A diagnosis of calcific miliary brain metastasis was made. Miliary calcification as an initial presentation of brain metastases in patients with lung cancer is uncommon. Use of oral tyrosine kinase inhibitor like gefitinib increases the likelihood development of calcific brain metastases due to the prolonged survival time contributed by its use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0028-3886.349672","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T03:55:57Z","timestamp":1692849357000},"page":"1197-1199","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Calcific Miliary Brain Metastasis in Adenocarcinoma Lung Treated with Gefitinib"],"prefix":"10.4103","volume":"70","author":[{"given":"K P","family":"Divya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajith","family":"Cherian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranab K","family":"Prabhakaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bejoy","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuldeep","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-60-20241013","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1440-1789.2007.00782.x","article-title":"Miliary brain metastasis presenting with dementia: Progression pattern of cancer metastases in the cerebral cortex","volume":"27","author":"Ogawa","year":"2007","journal-title":"Neuropathology"},{"key":"R2-60-20241013","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/1752-1947-6-279","article-title":"Miliary brain metastasis presenting with calcification in a patient with lung cancer: A case report","volume":"6","author":"Inomata","year":"2012","journal-title":"J Med Case Rep"},{"key":"R3-60-20241013","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1001\/archneurpsyc.1951.02320020033003","article-title":"Encephalitic form of metastatic carcinoma","volume":"65","author":"Madow","year":"1951","journal-title":"Arch Neurol"},{"key":"R4-60-20241013","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1212\/01.wnl.0000167540.89219.ac","article-title":"Encephalopathy in a patient with previous malignancy but normal brain imaging","volume":"65","author":"McGuigan","year":"2005","journal-title":"Neurology"},{"key":"R5-60-20241013","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1053\/sonc.2002.37263","article-title":"Role of angiogenesis in tumor growth and metastasis","volume":"29","author":"Folkman","year":"2002","journal-title":"Semin Oncol"},{"key":"R6-60-20241013","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jiph.2013.08.005","article-title":"Low seroprevalence of systemic cysticercosis among patients with epilepsy in Kerala--South India","volume":"7","author":"Cherian","year":"2014","journal-title":"J Infect Public Health"},{"key":"R7-60-20241013","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/annonc\/mdx671.042","article-title":"Calcified brain metastasis after systemic treatment predict long survival in advanced non-small cell lung cancer patients","volume":"28","author":"Kuo","year":"2017","journal-title":"Ann Oncol"}],"container-title":["Neurology India"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.349672","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:18:14Z","timestamp":1787836694000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.349672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/0028-3886.349672","relation":{},"ISSN":["0028-3886"],"issn-type":[{"value":"0028-3886","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]}}}