{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:38:36Z","timestamp":1787071116579,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Severe dysautonomia is typically seen during acute phase of Guillain\u2013Barr\u00e9 syndrome (GBS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate the relationship of cardiovascular autonomic dysfunction with motor recovery in GBS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Consecutive GBS patients presented to our hospital were recruited. Clinical assessment was evaluated with the Medical Research Council (MRC) sum score and GBS disability score (GDS). All patients had series of autonomic testing on admission and after treatment at 6 and 24 weeks. Both computation-dependent tests (heart rate variability [HRV] and baroreflex sensitivity [BRS]) and autonomic maneuvers were performed. Age- and gender-matched healthy controls (HC) were recruited. The data obtained at admission, 6 weeks and 24 weeks were compared within groups for statistical difference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Six patients (4 men; mean age 39.5 \u00b1 14.3 years) were recruited over one year. Five had GBS and one Miller Fisher syndrome. The mean MRC sum score and GDS on admission were 52.3 \u00b1 4.3 and 3.5 \u00b1 0.8 respectively. During admission, time-domain average RR interval (AVNN) and BRS were significantly poorer among cases compared to HC. Active standing 30:15 ratio and cold pressor test at admission were also significantly abnormal when compared with HC. All the autonomic parameters had normalized by 6 weeks and these were significant for the high frequency-HRV, BRS, and active standing 30:15 ratio. For MRC and GDS, there were significant improvements in the scoring over a period of 24 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Dysautonomia in GBS improved gradually and in keeping with motor and disability recovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0028-3886.359191","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T03:31:47Z","timestamp":1667273507000},"page":"1856-1859","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Cardiovascular Autonomic Assessment in Guillain\u2013Barr\u00e9 Syndrome: A Longitudinal Study"],"prefix":"10.4103","volume":"70","author":[{"given":"Cheng-Yin","family":"Tan","sequence":"first","affiliation":[{"name":"Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nortina","family":"Shahrizaila","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ting","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khean-Jin","family":"Goh","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maw-Pin","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"R1-20250926","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s10286-018-0542-y","article-title":"Autonomic involvement in Guillain-Barr\u00e9 syndrome: An update","volume":"29","author":"Zaeem","year":"2019","journal-title":"Clin Auton Res"},{"key":"R2-20250926","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0022-510X(91)90303-O","article-title":"Clinical signs in severe Guillain-Barr\u00e9 syndrome: Analysis of 63 patients","volume":"104","author":"de Jager","year":"1991","journal-title":"J Neurol Sci"},{"key":"R3-20250926","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1136\/jnnp.44.11.983","article-title":"Autonomic dysfunction in Guillain-Barr\u00e9 syndrome","volume":"44","author":"Tuck","year":"1981","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R4-20250926","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ana.410420207","article-title":"Quantitative assessment of cardiovascular autonomic function in Guillain-Barr\u00e9 syndrome","volume":"42","author":"Flachenecker","year":"1997","journal-title":"Ann Neurol"},{"key":"R5-20250926","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000047957","article-title":"A longitudinal cardiovascular autonomic function study in mild Guillain-Barr\u00e9 syndrome","volume":"47","author":"Lyu","year":"2002","journal-title":"Eur Neurol"},{"key":"R6-20250926","doi-asserted-by":"crossref","first-page":"398","DOI":"10.4103\/0028-3886.65926","article-title":"Selective autonomic screening in Guillain-Barr\u00e9 syndrome","volume":"58","author":"Yerdelen","year":"2010","journal-title":"Neurol India"},{"key":"R7-20250926","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s10286-018-0525-z","article-title":"Heart rate variability and baroreflex sensitivity abnormalities in Guillain-Barr\u00e9 syndrome: A pilot study","volume":"29","author":"Tan","year":"2019","journal-title":"Clin Auton Res"},{"key":"R8-20250926","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/ana.410440512","article-title":"Electrophysiological classification of Guillain-Barr\u00e9 syndrome: Clinical associations and outcome. Plasma Exchange\/Sandoglobulin Guillain-Barr\u00e9 Trial Group","volume":"44","author":"Hadden","year":"1998","journal-title":"Ann Neurol"},{"key":"R9-20250926","doi-asserted-by":"crossref","first-page":"115","DOI":"10.4103\/0028-3886.310102","article-title":"Preliminary Study of hsa-mir-626 Change in the Cerebrospinal Fluid in Parkinson's Disease","volume":"69","author":"Qin","year":"2021","journal-title":"Neurol India"},{"key":"R10-20250926","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.4103\/0028-3886.299153","article-title":"A Rare Fatal Cause of Acute Areflexic Quadriparesis in the Tropics","volume":"68","author":"Panda","year":"2020","journal-title":"Neurol India"},{"key":"R11-20250926","doi-asserted-by":"crossref","first-page":"369","DOI":"10.4103\/0028-3886.314529","article-title":"Utility of Serial Nerve Conduction Studies in the Electrodiagnosis of Guillain-Barre Syndrome","volume":"69","author":"Mani","year":"2021","journal-title":"Neurol India"},{"key":"R12-20250926","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4103\/0028-3886.310112","article-title":"Clinical Profile and Outcome of Guillain-Barre Syndrome in Pediatric Patients Admitted to a Tertiary Care Centre: A Retrospective Study","volume":"69","author":"Rangan","year":"2021","journal-title":"Neurol India"},{"key":"R13-20250926","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4103\/0028-3886.310063","article-title":"Clinical Characteristics and Predictors of Short-Term Outcome in Mexican Adult Patients with Guillain-Barr\u00e9 Syndrome","volume":"69","author":"Ruiz-Sandoval","year":"2021","journal-title":"Neurol India"},{"key":"R14-20250926","doi-asserted-by":"crossref","first-page":"376","DOI":"10.4103\/0028-3886.314554","article-title":"Sequential Nerve Conduction Studies in Guillain-Barre Syndrome: Is it Worth the Efforts?","volume":"69","author":"Nagappa","year":"2021","journal-title":"Neurol India"},{"key":"R15-20250926","doi-asserted-by":"crossref","first-page":"230","DOI":"10.4103\/0028-3886.279682","article-title":"Limb Myokymia in Guillain-Barr\u00e9 Syndrome","volume":"68","author":"Kuttiappan","year":"2020","journal-title":"Neurol India"}],"container-title":["Neurology India"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.359191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:41:43Z","timestamp":1787067703000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.359191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/0028-3886.359191","relation":{},"ISSN":["0028-3886","1998-4022"],"issn-type":[{"value":"0028-3886","type":"print"},{"value":"1998-4022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"2020-02-20","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}