{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:38:59Z","timestamp":1787071139589,"version":"build-2736575974"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>We evaluated dynamic changes in neurophysiology of Guillain-Barr\u00e9 syndrome (GBS) at different time points and the role of demyelination and axonal burden in predicting outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Nerve conduction study (NCS) was done in 44 GBS patients at admission and at 1 and 3 months, and were categorized into acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy (AMAN), acute motor sensory axonal neuropathy (AMSAN), equivocal and in-excitable motor nerve (IMN). The demyelinating and axonal burden on motor NCS at admission, 1 and 3 months were computed and correlated with disability at 3 and 6 months. Disability was assessed using Clinical Grading Scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Twenty-four (54.3%) had AIDP, 5 (11.4%) AMAN, 12 (27.3%) equivocal and 3 (6.8%) had IMN at admission. Maximum instability was noted in equivocal group; majority of whom became AIDP at three months. Neurophysiological subtypes at different time points did not correlate with 6 months disability, but demyelination burden at admission (r = -0.42;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.005) and axonal burden at one month (r = 0.43;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04) correlated with six months disability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Inverse correlation of axonal burden at one and three months with disability suggests role of secondary axonal damage in predicting outcome. Repeat NCS at one month helps in categorizing GBS and also in prognostication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0028-3886.359245","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T03:31:47Z","timestamp":1667273507000},"page":"1995-2002","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic Significance of Serial Nerve Conduction in GB Syndrome"],"prefix":"10.4103","volume":"70","author":[{"given":"Jayantee","family":"Kalita","sequence":"first","affiliation":[{"name":"Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mritunjai","family":"Kumar","sequence":"additional","affiliation":[{"name":"Currently Working in Department of Neurology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, 249203, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha K","family":"Misra","sequence":"additional","affiliation":[{"name":"Ex-HOD, Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Currently Working in Apollo Medics Super-Specialty Hospitals and Senior Consultant Neurologist, Vivekanand Polyclinic, and Institute of Medical Sciences, Lucknow, 22600, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"R1-20250926","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1136\/jnnp.2007.118000","article-title":"Neurophysiological criteria in the diagnosis of different clinical types of Guillain-Barre syndrome","volume":"79","author":"Kalita","year":"2008","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R2-20250926","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/mus.880120602","article-title":"Acquired inflammatory demyelinating polyneuropathies: Clinical and electrodiagnostic features","volume":"12","author":"Albers","year":"1989","journal-title":"Muscle Nerve"},{"key":"R3-20250926","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(16)00339-1","article-title":"Guillain-Barr\u00e9 syndrome","volume":"388","author":"Willison","year":"2016","journal-title":"Lancet"},{"key":"R4-20250926","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/ana.410440210","article-title":"IgG anti-GM1 antibody is associated with reversible conduction failure and axonal degeneration in Guillain-Barre syndrome","volume":"44","author":"Kuwabara","year":"1998","journal-title":"Ann Neurol"},{"key":"R5-20250926","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1093\/brain\/awq260","article-title":"Conduction block in acute motor axonal neuropathy","volume":"133","author":"Kokubun","year":"2010","journal-title":"Brain"},{"key":"R6-20250926","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1212\/WNL.61.5.617","article-title":"Acute motor conduction block neuropathy: Another Guillain-Barre syndrome variant","volume":"61","author":"Capasso","year":"2003","journal-title":"Neurology"},{"key":"R7-20250926","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1136\/jnnp.2010.208538","article-title":"Pitfalls in electrodiagnosis of Guillain-Barre syndrome subtypes","volume":"81","author":"Uncini","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R8-20250926","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0022-510X(93)90324-R","article-title":"Severe axonal degeneration in acute Guillain-Barr\u00e9 syndrome: Evidence of two different mechanisms?","volume":"116","author":"Feasby","year":"1993","journal-title":"J Neurol Sci"},{"key":"R9-20250926","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/mus.880141011","article-title":"Axonal damage in Guillain-Barr\u00e9 syndrome","volume":"14","author":"van der Mech\u00e9","year":"1991","journal-title":"Muscle Nerve"},{"key":"R10-20250926","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/ana.410440512","article-title":"Electrophysiological classification of Guillain\u2013Barre\u00d7syndrome: Clinical associations and outcome. Plasma exchange\/Sandoglobulin Guillain\u2013Barre\u00d7syndrometrial group","volume":"44","author":"Hadden","year":"1998","journal-title":"Ann Neurol"},{"issue":"Suppl","key":"R11-20250926","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1002\/ana.410270707","article-title":"Assessment of current diagnostic criteria for Guillain-Barre syndrome","volume":"27","author":"Asbury","year":"1990","journal-title":"Ann Neurol"},{"key":"R12-20250926","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1093\/brain\/119.4.1055","article-title":"Plasma-exchange therapy in chronic inflammatory demyelinating polyneuropathy. A double-blind, sham controlled cross-over study","volume":"119","author":"Hahn","year":"1996","journal-title":"Brain"},{"key":"R14-20250926","first-page":"S225","article-title":"Guidelines in electrodiagnostic medicine. Consensus criteria for the diagnosis of partial conduction block","volume":"8","author":"Olney","year":"1999","journal-title":"Muscle Nerve Suppl"},{"key":"R15-20250926","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1093\/brain\/119.6.2053","article-title":"The prognosis and main prognostic indicators of Guillain-Barre syndrome. A multicenter prospective study of 297 patients","volume":"119","year":"1996","journal-title":"Brain"},{"key":"R16-20250926","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1586\/ern.09.43","article-title":"Electrophysiologic and immunopathologic correlates in Guillain-Barre syndrome subtypes","volume":"9","author":"Uncini","year":"2009","journal-title":"Expert Rev Neurother"},{"key":"R17-20250926","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/mus.25577","article-title":"Electrodiagnosis of reversible conduction failure in Guillain-Barr\u00e9 syndrome","volume":"56","author":"Chan","year":"2017","journal-title":"Muscle Nerve"},{"key":"R18-20250926","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/qjmed\/hcv190","article-title":"Outcome of Guillain-Barre syndrome patients with respiratory paralysis","volume":"109","author":"Kalita","year":"2016","journal-title":"QJM"},{"key":"R19-20250926","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.clinph.2012.01.025","article-title":"Electrodiagnostic criteria for Guillain-Barr\u00e8 syndrome: A critical revision and the need for an update","volume":"123","author":"Uncini","year":"2012","journal-title":"Clin Neurophysiol"},{"key":"R20-20250926","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/j.clinph.2012.12.047","article-title":"Two sets of nerve conduction studies may suffice in reaching a reliable electrodiagnosis in Guillain-Barr\u00e9 syndrome","volume":"124","author":"Shahrizaila","year":"2013","journal-title":"Clin Neurophysiol"},{"key":"R21-20250926","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jns.2015.07.018","article-title":"Influence of timing on electrodiagnosis of Guillain-Barr\u00e9 syndrome in the first six weeks: A retrospective study","volume":"357","author":"Rajabally","year":"2015","journal-title":"J Neurol Sci"},{"key":"R22-20250926","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00005792-196905000-00001","article-title":"The inflammatory lesion in idiopathic polyneuritis. Its role in pathogenesis","volume":"48","author":"Asbury","year":"1969","journal-title":"Medicine (Baltimore)"},{"key":"R23-20250926","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1212\/01.WNL.0000133205.05169.04","article-title":"Does Campylobacter jejuni infection elicit \u201cdemyelinating\u201d Guillain-Barre syndrome?","volume":"63","author":"Kuwabara","year":"2004","journal-title":"Neurology"},{"key":"R24-20250926","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1097\/PCC.0000000000001935","article-title":"Role of IV Immunoglobulin in Indian Children With Guillain-Barr\u00e9 Syndrome","volume":"20","author":"Kalita","year":"2019","journal-title":"Pediatr Crit Care Med"},{"key":"R25-20250926","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4103\/0028-3886.310112","article-title":"Clinical Profile and Outcome of Guillain-Barre Syndrome in Pediatric Patients Admitted to a Tertiary Care Centre: A Retrospective Study","volume":"69","author":"Rangan","year":"2021","journal-title":"Neurol India"},{"key":"R26-20250926","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4103\/0028-3886.310063","article-title":"Clinical Characteristics and Predictors of Short-Term Outcome in Mexican Adult Patients with Guillain-Barr\u00e9 Syndrome","volume":"69","author":"Ruiz-Sandoval","year":"2021","journal-title":"Neurol India"},{"key":"R27-20250926","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4103\/0028-3886.279657","article-title":"The Association of Guillain-Barr\u00e9 Syndrome with Pulmonary Tuberculosis: Chance or Causal?","volume":"68","author":"Singh","year":"2020","journal-title":"Neurol India"},{"key":"R28-20250926","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.4103\/0028-3886.329589","article-title":"A Hypopituitarism Patient with Bickerstaff's Brainstem Encephalitis Overlapped by Guillain-Barr\u00e9 Syndrome: A Case Report","volume":"69","author":"Deng","year":"2021","journal-title":"Neurol India"},{"key":"R29-20250926","doi-asserted-by":"crossref","first-page":"230","DOI":"10.4103\/0028-3886.279682","article-title":"Limb Myokymia in Guillain-Barr\u00e9 Syndrome","volume":"68","author":"Kuttiappan","year":"2020","journal-title":"Neurol India"},{"key":"R30-20250926","doi-asserted-by":"crossref","first-page":"376","DOI":"10.4103\/0028-3886.314554","article-title":"Sequential Nerve Conduction Studies in Guillain-Barre Syndrome: Is it Worth the Efforts?","volume":"69","author":"Nagappa","year":"2021","journal-title":"Neurol India"},{"key":"R31-20250926","doi-asserted-by":"crossref","first-page":"369","DOI":"10.4103\/0028-3886.314529","article-title":"Utility of Serial Nerve Conduction Studies in the Electrodiagnosis of Guillain-Barre Syndrome","volume":"69","author":"Mani","year":"2021","journal-title":"Neurol India"},{"key":"R32-20250926","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.4103\/0028-3886.294550","article-title":"Genetically Established Familial Amyloidotic Polyneuropathy from India: Narrating the Diagnostic \u201cOdyssey\u201d and a Mini Review","volume":"68","author":"Nagappa","year":"2020","journal-title":"Neurol India"},{"key":"R33-20250926","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.4103\/0028-3886.333491","article-title":"Rare Case of Reversible Polyneuropathy after Levetiracetam Overdose","volume":"69","author":"Moon","year":"2021","journal-title":"Neurol India"},{"key":"R34-20250926","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.4103\/0028-3886.333514","article-title":"Pseudo-Myotonic Reaction and Pseudo-Polyneuropathy Type Sensory Disturbances in Chronic Cervical Compressive Myelopathy","volume":"69","author":"Anthony","year":"2021","journal-title":"Neurol India"},{"key":"R35-20250926","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.4103\/0028-3886.355104","article-title":"Severe Acute Respiratory Syndrome Coronavirus Two (SARS-CoV-2) Associated Guillain-Barre Syndrome","volume":"70","author":"Ramineni","year":"2022","journal-title":"Neurol India"},{"key":"R36-20250926","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.4103\/0028-3886.349608","article-title":"Community Acquired Staphylococcus Aureus Necrotizing Pneumonia and Guillain Barre Syndrome: An Unusual Presentation in An Adolescent Patient","volume":"70","author":"Surve","year":"2022","journal-title":"Neurol India"}],"container-title":["Neurology India"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.359245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:42:05Z","timestamp":1787067725000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0028-3886.359245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/0028-3886.359245","relation":{},"ISSN":["0028-3886","1998-4022"],"issn-type":[{"value":"0028-3886","type":"print"},{"value":"1998-4022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"2019-08-02","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-16","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}