{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:38:41Z","timestamp":1787071121078,"version":"build-2736575974"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Migraine is one of the primary headaches having a global prevalence of 15%. It is characterized by neurovascular dysfunction and recurrent episodes of headache. The hyperexcitability of the cerebral cortex has been recognized as an important factor in the pathogenesis of migraine, and magnesium (Mg) being a regulator of neuronal excitability is thought to participate in migraine pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To determine the serum levels of Mg in patients of migraine during the attack and in between attacks as compared to healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 50 patients of migraine who fulfilled inclusion criteria were enrolled in the study along with the same number of healthy controls. International Classification of Headache Disorders 3\n                      <jats:sup>rd<\/jats:sup>\n                      Edition, 2013 (ICHD-III) criteria was used for the diagnosis of migraine.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean serum Mg in migraine cases during the interictal phase was lower than healthy controls (1.849 \u00b1 0.135 vs 2.090 \u00b1 0.205,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), which was statistically significant. It was also found that mean serum Mg during attacks was significantly lower than in between attacks (1.822 \u00b1 0.149 vs 1.849 \u00b1 0.135,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003). Serum Mg levels in migraine cases showed an inverse linear relationship with the frequency of attacks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Relatively low serum Mg in migraine cases when compared with healthy controls and inverse relation of serum Mg levels with the frequency of migraine attacks suggests that Mg is significantly involved in mechanisms underlying migraine pathogenesis, which can be explored as a therapeutic option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0028-3886.359247","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T03:31:06Z","timestamp":1667273466000},"page":"1852-1855","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Serum Magnesium Levels During the Ictal and Interictal Phase in Patients of Migraine: A Prospective Observational Study"],"prefix":"10.4103","volume":"70","author":[{"given":"Rahul","family":"Mahajan","sequence":"first","affiliation":[{"name":"Department of Neurology, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuljeet Singh","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Neurology, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh Kumar","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Neurology, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Juneja","sequence":"additional","affiliation":[{"name":"Department of Neurology, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"issue":"Supplement","key":"R1-20250926","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.4103\/0028-3886.315988","article-title":"Biomarkers in Migraine","volume":"69","author":"Yan","year":"2021","journal-title":"Neurol India"},{"key":"R2-20250926","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/S0140-6736(12)61729-2","article-title":"Year lived with disability (YLDs) for 110 sequelae of 289 diseases and injuries: A systematic analysis for the global burden of disease study 2010","volume":"380","author":"Vos","year":"2012","journal-title":"Lancet"},{"key":"R3-20250926","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10072-013-1387-8","article-title":"Burden of migraine: International perspectives","volume":"34","author":"Leonardi","year":"2013","journal-title":"Neurol Sci"},{"issue":"Supplement","key":"R4-20250926","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.4103\/0028-3886.315995","article-title":"Acute Treatment of Migraine: What has Changed in Pharmacotherapies?","volume":"69","author":"Yang","year":"2021","journal-title":"Neurol India"},{"key":"R5-20250926","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nm0202-136","article-title":"Intrinsic brain activity triggers trigeminal meningeal afferents in migraine model","volume":"8","author":"Bolay","year":"2002","journal-title":"Nat Med"},{"issue":"Supplement","key":"R6-20250926","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.4103\/0028-3886.315972","article-title":"Chronic Migraine: An Update on Diagnosis and Management","volume":"69","author":"Gribbin","year":"2021","journal-title":"Neurol India"},{"issue":"Supplement","key":"R7-20250926","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.4103\/0028-3886.315974","article-title":"Migraine and Vascular Risk: An Update","volume":"69","author":"Gupta","year":"2021","journal-title":"Neurol India"},{"key":"R8-20250926","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1046\/j.1526-4610.1996.3606357.x","article-title":"Electromyographical ischemic test and intracellular and extracellular magnesium concentration in migraine and tension-type headache patients","volume":"36","author":"Mazzotta","year":"1996","journal-title":"Headache"},{"key":"R9-20250926","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1177\/0333102413485658","article-title":"The International classification of headache disorders: 3rd edition","volume":"33","year":"2013","journal-title":"Cephalalgia"},{"key":"R10-20250926","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1046\/j.1468-2982.1992.1201021.x","article-title":"Serum and salivary magnesium levels in migraine and tension type headache. 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